Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration

Vandenbroucke, Jan P.; Elm, Erik von; Altman, Douglas G.; Gøtzsche, Peter C; Mulrow, Cynthia D.; Pocock, Stuart J.; Poole, Charles; Schlesselman, James J.; Egger, Matthias

doi:10.1016/j.ijsu.2014.07.014

Cited by 3,073 publications

(2,688 citation statements)

References 216 publications

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“…Funnel plots were made to assess possible publication bias. The STROBE statement was used for the quality assessment of cohort and case-control studies [12]. For case series, quality assessment was based on a clear description of the study objective, the inclusion period, inclusion and exclusion criteria, the intervention, the outcome measures, and completeness of follow-up.…”

Section: Methodsmentioning

confidence: 99%

Doxapram Treatment for Apnea of Prematurity: A Systematic Review

et al. 2016

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Background: Apnea of prematurity (AOP) is a common complication of preterm birth, for which caffeine is the first treatment of choice. In case of persistent AOP, doxapram has been advocated as an additional therapy. Objective: To identify and appraise all existing evidence regarding efficacy and safety of doxapram use for AOP in infants born before 34 weeks of gestational age. Methods: All studies reporting on doxapram use for AOP were identified by searching electronic databases, references from relevant studies, and abstracts from the Societies for Pediatric Research. Two reviewers independently assessed study eligibility and quality, and extracted data on study design, patient characteristics, efficacy and safety outcomes. Results: The randomized controlled trials showed less apnea during doxapram treatment when compared to placebo, but no difference in treatment effect when compared to theophylline. No serious adverse effects were reported. We identified 28 observational studies consisting mainly of cohort studies and case series (n = 1,994). There was considerable heterogeneity in study design and quality. Most studies reported a positive effect of doxapram on apnea rate. A few studies reported on long-term outcomes with conflicting results. A range of possible doxapram-related short-term adverse effects were reported, sometimes associated with the use of higher doses. Conclusion: Based on the limited number of studies and level of evidence, no firm conclusions on the efficacy and safety of doxapram in preterm infants can be drawn. For this reason, routine use cannot be recommended. A large multicenter randomized controlled trial is urgently needed to provide more conclusive evidence.

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Section: Methodsmentioning

confidence: 99%

Doxapram Treatment for Apnea of Prematurity: A Systematic Review

et al. 2016

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“…The study was approved by the local Medical Ethical Committee (Academic Medical Center, Amsterdam, Netherlands, 2015_80) and was registered in clinicaltrials.gov registry (NCT02739191). Reporting of the study is in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines [12]. The study was performed in a single academic centre.…”

Section: Methodsmentioning

confidence: 99%

Prophylactic negative pressure wound therapy after lower extremity fracture surgery: a pilot study

Dingemans

Birnie

Backes

et al. 2018

International Orthopaedics (SICOT)

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Purpose Infectious complications following lower extremity fracture surgery are a major concern and account for a substantial socio-economic burden to society. The aim of this pilot study was to investigate the feasibility of a new portable single-use negative pressure wound therapy device in patients undergoing major foot ankle surgery. Methods Patients undergoing major foot ankle fracture surgery at a single level 1 trauma centre were eligible for this prospective case series. Patient characteristics were collected, as were fracture and surgical characteristics. Primary outcome was surgical site infection within 30 days as classified by the criteria from the Centers for Disease Control and Prevention. Patients in the prospective cohort were case-matched with a historical cohort from the same institution. Results Sixty patients were included. In seven patients, the NPWT failed and treatment was ceased. Mean age was 44 years and 85% was ASA 1; 43% of the patients were actively smoking. Indications for surgery were midfoot, calcaneal, talar, and ankle fractures. In 53 patients, four (7.5%) surgical site infections occurred, two superficial (3.3%) and two (3.3%) deep infections. For 47 patients, a match was available. The incidence of surgical site infection did not statistically significantly differ between the prospective cohort and retrospective matched cohort (4.3 versus 14.9%, p = 0.29, respectively). This was also the case when looking at superficial and deep surgical site infections separately (0 versus 8.5%, p = 0.08, and 4.3 versus 6.4%, respectively). Conclusion We have observed surgical site infections in 7.5% of the patients with the use of prophylactic negative pressure wound therapy. The incidence of surgical site infections was not statistically significantly lower compared to a matched historical cohort.

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“…Therefore, and in agreement with current recommendations for observational studies, we did not formally adjust for multiple testing. 38 Another strength is that our study was large enough to investigate potential nonlinear associations with continuous outcomes. The primary limitation of our study is its observational nature.…”

Section: Discussionmentioning

confidence: 99%

Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima–Media Thickness

Hertle

Arts

Kallen

et al. 2016

ATVB

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12associations with future CVD. When the effect of MBL on complications of established CVD was investigated, low MBL was in fact protective in most studies. [13][14][15] Thus, considerable discrepancy remains in the literature on whether MBL has beneficial or adverse effects in CVD.This reported discrepancy might be explained by a dual role of MBL in different etiologic aspects of CVD. Objective-Previous studies suggested that the lectin-complement pathway plays a complex role in cardiovascular disease (CVD). To date, no prospective human studies have investigated the relationship between the initiating factor of the lectin pathway, that is, mannose-binding lectin (MBL), and low-grade inflammation, endothelial dysfunction, or carotid intima-media thickness (cIMT). Moreover, MBL-associated proteases (MASPs) and MBL-associated proteins (MAps), which mediate downstream complement activation, have not been studied in the development of CVD. Approach and Results-In a prospective cohort (n=574; age 60±7 years; 7-year follow-up), we investigated longitudinal associations of plasma MBL, MASP-1, MASP-2, MASP-3, and MAp44 with biomarker scores that reflect low-grade inflammation and endothelial dysfunction, respectively, and with cIMT. We also investigated their associations with incident CVD (n=73). In adjusted analyses, low-grade inflammation was lowest in the middle tertile (T Middle )

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Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration

Cited by 3,073 publications

References 216 publications

Doxapram Treatment for Apnea of Prematurity: A Systematic Review

Doxapram Treatment for Apnea of Prematurity: A Systematic Review

Prophylactic negative pressure wound therapy after lower extremity fracture surgery: a pilot study

Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima–Media Thickness

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