Streptococcus mutans and Streptococcus sobrinus colonization and caries experience in 3- and 5-year-old Thai children

Saraithong, Prakaimuk; Pattanaporn, Komkham; Chen, Z.; Khongkhunthian, Sakornrat; Laohapensang, P.; Chhun, Nok; Pattanaporn, W.; Gaw, H. Y.; Li, Yihong

doi:10.1007/s00784-015-1437-0

Cited by 32 publications

(26 citation statements)

References 30 publications

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“…Early childhood caries (ECC) remains one of the most common chronic diseases of childhood [ 15 , 16 ], particularly in China. Many reports have stated that S. mutans demonstrates a strong relationship with ECC [ 17 , 18 ]. However, not every individual colonized by S. mutans will have dental decay.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children

Zhuang¹,

Yu²,

Liao³

et al. 2018

BMC Oral Health

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BackgroundThe VicRK two-component signalling system regulates virulence and cariogenicity in Streptococcus mutans (S. mutans). The purpose of this study was to explore the genetic polymorphisms of the vicR and vicK genes, which are associated with dental caries in children with S. mutans.MethodsIn this study, 121 (from each group) clinical S. mutans strains were isolated from caries-free children and children with high-severity caries to sequence the vicR and vicK genes. Genomic DNA was extracted from S. mutans strains and amplified using PCR. The PCR products were purified and sequenced. A chi-squared test and ABI Variant Reporter software were used to analyse the sequencing results.ResultsThe 242 clinically isolated S. mutans strains contained the full-length vicR and vicK genes. No nucleotide sequence insertions or deletions were observed in the two genes. Four silent point mutations were identified in the vicR genes, and no missense mutations could be detected. Forty-one mutations were identified in the vicK genes. In addition to 32 silent mutations, 9 missense mutations at the 173, 337, 470, 1051, 1132, 1258, 1260, 1277, and 1348 bp positions were found. The distribution frequencies of the missense mutations were not significantly different between the groups, except for the C470T mutation. The frequency of the C470T missense mutation was higher in the high-severity caries group than in the caries-free group.ConclusionsvicR sequences are highly conserved in S. mutans clinical isolates. The locus 470 missense mutation of the vicK gene may be related to caries in children with S. mutans.

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Section: Introductionmentioning

confidence: 99%

Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children

Zhuang¹,

Yu²,

Liao³

et al. 2018

BMC Oral Health

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“…That saliva‐transfer behaviour of giving children food or bottles that have been in contact with the carer's mouth occurred frequently during early stages of infancy is concerning as early exposure to large numbers of mutans streptococci is linked with a higher risk of developing dental caries, when combined with high sugar (Fan et al, 2016; Finlayson, Gupta, & Ramos‐Gomez, 2017; Saraithong et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Are Australian parents following feeding guidelines that will reduce their child's risk of dental caries?

Martin-Kerry

Gussy

Gold

et al. 2020

Child

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Background Early childhood is an important time to establish eating behaviours and taste preferences, and there is strong evidence of the association between the early introduction of sugar‐sweetened beverages and obesity and dental caries (tooth decay). Dental caries early in life predicts lifetime caries experience, and worldwide expenditure for dental caries is high. Methods Questionnaire data from the Splash! longitudinal birth cohort study of young children in Victoria, Australia was used to examine beverage consumption and parental feeding behaviours of young children, aiming to provide contemporary dietary data and assess consistency with the Australian dietary guidelines. Results From 12 months of age, the proportion of children drinking sugar‐sweetened beverages consistently increased with age (e.g. fruit juice consumed by 21.8% at 12 months and 76.7% at 4 years of age). However, the most common beverages for young children are milk and water, consistent with Australian dietary guidelines. In relation to other risk factors for dental caries, at 6 months of age children were sharing utensils, and at 12 months three quarters of carers tasted the child's food before feeding. Conclusions The increasing consumption of sugar‐sweetened beverages and prevalence of other risk factors for dental caries and obesity through early childhood continues to be a problem despite efforts to raise awareness of these issues with parents.

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“…There are more than 700 bacterial species colonized in the oral cavity. Among them, S. mutans is identified as the most important pathogenic bacteria for dental caries [28,29]. Recent studies suggest that the virulence of S. mutans isolated from caries-active subjects is high in comparison to that in caries-free subjects [12,13].…”

Section: Discussionmentioning

confidence: 99%

Phenotypes of Streptococcus mutans isolates in sound and cavitated tooth surfaces and its relationship to early childhood caries in China

Liu

Guo

et al. 2019

Preprint

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Background To compare the phenotypes of Streptococcus mutans (S. mutans ) strains isolated from sites with different caries susceptibility of a single subject. Methods This study was carried out in children with early-childhood caries (ECC) and caries-free (CF). The ECC subjects presented two sites: a cavitated lesion (ECC-C) and a sound surface (ECC-F). The CF subjects presented one sound surface. The following phenotypes were evaluated among these three sites: growth pattern, biofilm, exopolysaccharide (EPS), pH drop, and the expression levels of genes (gtfB, gtfC, spaP, srtA, relA, ffh, srn225147, and srn821798). Results All of these phenotypes were detected similarly between ECC-C and ECC-F groups. However, the capacity of biofilm formation, EPS, pH drop and the expression levels of genes (gtfB and spaP) of S. mutans in the CF group were lower compared to those of the ECC group. There was a relatively higher expression of srn821798 compared to that of srn225147 in clinical isolates, and isolates with low expression of srn821798 had lower expression levels of predicted targets (gtfB, gtfC, and spaP). Conclusions These data indicate S. mutans isolated from sites with different caries susceptibility of a single subject showed similar characteristics, while the cariogenic potential of the S. mutans isolated from ECC individuals was relatively higher than that of CF subjects.

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Streptococcus mutans and Streptococcus sobrinus colonization and caries experience in 3- and 5-year-old Thai children

Cited by 32 publications

References 30 publications

Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children

Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children

Are Australian parents following feeding guidelines that will reduce their child's risk of dental caries?

Phenotypes of Streptococcus mutans isolates in sound and cavitated tooth surfaces and its relationship to early childhood caries in China

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