Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis

Esposito, Susanna; Colombo, Carla; Tosco, Antonella; Montemitro, Enza; Volpi, Sonia; Ruggiero, Luca; Lelii, Mara; Bisogno, Arianna; Pelucchi, Claudio; Principi, Nicola

doi:10.1016/j.jcf.2015.05.008

Cited by 15 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We do not have a clear explanation for this finding. It is well-known that influenza vaccination has a role in prevention of pneumococcal infection 22,23 and in our study performed in patients with cystic fibrosis, 24 the majority of whom were vaccinated against influenza, influenza vaccination coverage was similar between carriers and non-carriers.…”

Section: Discussionsupporting

confidence: 50%

Streptococcus pneumoniaepharyngeal colonization in school-age children and adolescents with cancer

Principi

Preti

Gaspari

et al. 2015

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

Patients with cancer, particularly those with hematologic malignancies, are at an increased risk of invasive pneumococcal disease (IPD) and they are included in the list of subjects for whom pneumococcal vaccination is recommended. The main aim of this study was to evaluate Streptococcus pneumoniae colonization in school-aged children and adolescents with cancer to determine the potential protective efficacy of 13-valent pneumococcal conjugate vaccine (PCV13). An oropharyngeal swab was obtained from 277 patients (age range 6-17 years) with cancer during routine clinical visits and analyzed for S. pneumoniae using real-time polymerase chain reaction. S. pneumoniae was identified in 52 patients (18.8%), including 47/235 (20.0%) with hematologic malignancies and 5/42 (11.9%) with solid tumors. Colonization declined significantly with an increase in age (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.16-0.71, and OR 0.30, 95% CI 0.11-0.82 in children aged 10-14 and 15 years, respectively, as compared to those <10 years). Carriage was more common among patients with leukemia or lymphoma than in children with solid tumors. Co-trimoxazole prophylaxis was significantly associated with reduced pneumococcal carriage (OR 0.41, 95% CI 0.19-0.89). A total of 15/58 (25.9%) and 26/216 (12.0%) children were colonized by PCV13 serotypes among cancer patients previously vaccinated and not vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7), respectively. In conclusion, this study indicates that children and adolescents with cancer are frequently colonized by S. pneumoniae. Because most of the carried serotypes are included in PCV13, this vaccine is presently the best solution to reduce the risk of IPD in these patients.

show abstract

Section: Discussionsupporting

confidence: 50%

Streptococcus pneumoniaepharyngeal colonization in school-age children and adolescents with cancer

Principi

Preti

Gaspari

et al. 2015

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, 15 of 318 (4.7%) adults examined in a retrospective study were culture positive for group A streptococcus (GAS) in their sputum, and 7/15 of these patients were suffering from an exacerbation at the time of the positive culture (32), analogous to the observations made for SMG isolates and exacerbation described above. In another study, ϳ20% of the 212 children with CF studied were shown to have detectable Streptococcus pneumoniae when oropharyngeal swab specimens were analyzed by quantitative PCR (33). Interestingly, Dennis and colleagues showed that mucoid variants of S. pneumoniae could be isolated from the sputum of children with CF (32).…”

Section: Is There a Role For Typical Pathogenic Streptococci In Cf?mentioning

confidence: 99%

The Yin and Yang of Streptococcus Lung Infections in Cystic Fibrosis: a Model for Studying Polymicrobial Interactions

Scott

O’Toole

2019

J Bacteriol

View full text Add to dashboard Cite

The streptococci are increasingly recognized as a core component of the cystic fibrosis (CF) lung microbiome, yet the role that they play in CF lung disease is unclear. The presence of the Streptococcus milleri group (SMG; also known as the anginosus group streptococci [AGS]) correlates with exacerbation when these microbes are the predominant species in the lung. In contrast, microbiome studies have indicated that an increased relative abundance of streptococci in the lung, including members of the oral microflora, correlates with impacts on lung disease less severe than those caused by other CF-associated microflora, indicating a complex role for this genus in the context of CF. Recent findings suggest that streptococci in the CF lung microenvironment may influence the growth and/or virulence of other CF pathogens, as evidenced by increased virulence factor production by Pseudomonas aeruginosa when grown in coculture with oral streptococci. Conversely, the presence of P. aeruginosa can enhance the growth of streptococci, including members of the SMG, a phenomenon that could be exacerbated by the fact that streptococci are not susceptible to some of the frontline antibiotics used to treat P. aeruginosa infections. Collectively, these studies indicate the necessity for further investigation into the role of streptococci in the CF airway to determine how these microbes, alone or via interactions with other CF-associated pathogens, might influence CF lung disease, for better or for worse. We also propose that the interactions of streptococci with other CF pathogens is an ideal model to study clinically relevant microbial interactions.

show abstract

“…pneumoniae is a Gram-positive coccus that can survive under both aerobic and anaerobic conditions [59]. It causes mucosal and invasive infections in children and adults, most commonly acute otitis media (AOM), community-acquired pneumonia (CAP), and invasive pneumococcal diseases (IPD), such as bacteraemia and meningitis [60][61][62][63][64].…”

Section: Pneumococcal Vaccinationmentioning

confidence: 99%

Vaccination against Paediatric Respiratory Pathogens

et al. 2019

View full text Add to dashboard Cite

Acute respiratory infections (ARIs) are extremely common in children, especially those under 5 years old. They can lead to complications, super-infection, respiratory failure, and even compromised respiratory function in adulthood. For some of the responsible pathogens, vaccines are available. This review reports current issues about vaccines against the main respiratory pathogens to highlight the available strategies to reduce the burden of paediatric respiratory disease. The optimal use of influenza, pneumococcal, pertussis and measles vaccines is required in order to reduce ARI burden. Vaccination coverage rates must be improved to achieve the full benefits of these vaccines. Recently, advances in the knowledge of respiratory syncytial virus structural biology and immunology as well as the development of new techniques to generate vaccine candidates have increased the number of promising vaccines even against this harmful pathogen.

show abstract

Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis

Abstract: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.

Cited by 15 publications

References 21 publications

Streptococcus pneumoniaepharyngeal colonization in school-age children and adolescents with cancer

Streptococcus pneumoniaepharyngeal colonization in school-age children and adolescents with cancer

The Yin and Yang of Streptococcus Lung Infections in Cystic Fibrosis: a Model for Studying Polymicrobial Interactions

Vaccination against Paediatric Respiratory Pathogens

Contact Info

Product

Resources

About