Streptomyces corynorhini sp. nov., isolated from Townsend’s big-eared bats (Corynorhinus townsendii)

Hamm, Paris S.; Caimi, Nicole A.; Northup, Diana E.; Valdez, Ernest W.; Buecher, Debbie C.; Dunlap, Christopher A.; Labeda, David P.; Porras‐Alfaro, Andrea

doi:10.1007/s10482-019-01261-z

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…This genus is responsible for a significant portion of all isolated and identified natural compounds such as antibiotics [10, 11]. For this reason, the genus Streptomyces has become the main focus of isolation and investigation studies of the novel species from different habitats such as deserts [12–15], bats [16], fruits [17], insects [18, 19], lake sediments [20, 21], manganese-contaminated soil [22], mangrove sediments [23, 24], mangrove soil [25], marine sponges [26, 27], marine sediments [28, 29], rhizospheres [30, 31], zinc and copper mine [32], and plant tissues [33, 34] and soil [35, 36]. In this study, it was aimed to isolate novel actinobacteria from soil samples collected from the Karakum Desert.…”

Section: Full-textmentioning

confidence: 99%

Streptomyces cahuitamycinicus sp. nov., isolated from desert soil and reclassification of Streptomyces galilaeus as a later heterotypic synonym of Streptomyces bobili

Saygin

Güven

et al. 2020

International Journal of Systematic and Evolutionary Microbiology

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Section: Full-textmentioning

confidence: 99%

Streptomyces cahuitamycinicus sp. nov., isolated from desert soil and reclassification of Streptomyces galilaeus as a later heterotypic synonym of Streptomyces bobili

Saygin

Güven

et al. 2020

International Journal of Systematic and Evolutionary Microbiology

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“…protection of their eggs and larvae against opportunistic pathogens [11]. Vertebrates have not been as frequently sampled as invertebrates for Streptomyces, but bats have been reported to harbour Streptomyces on their skin surface [18][19][20]. The role of Streptomyces in bats may be significant, yet limited data are available to ascertain whether they form a symbiotic relationship with bats.…”

Section: Introductionmentioning

confidence: 99%

Ecology shapes the genomic and biosynthetic diversification of Streptomyces bacteria from insectivorous bats

Montoya-Giraldo,

Piper,

Ikhimiukor

et al. 2024

Microbial Genomics

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Streptomyces are prolific producers of secondary metabolites from which many clinically useful compounds have been derived. They inhabit diverse habitats but have rarely been reported in vertebrates. Here, we aim to determine to what extent the ecological source (bat host species and cave sites) influence the genomic and biosynthetic diversity of Streptomyces bacteria. We analysed draft genomes of 132 Streptomyces isolates sampled from 11 species of insectivorous bats from six cave sites in Arizona and New Mexico, USA. We delineated 55 species based on the genome-wide average nucleotide identity and core genome phylogenetic tree. Streptomyces isolates that colonize the same bat species or inhabit the same site exhibit greater overall genomic similarity than they do with Streptomyces from other bat species or sites. However, when considering biosynthetic gene clusters (BGCs) alone, BGC distribution is not structured by the ecological or geographical source of the Streptomyces that carry them. Each genome carried between 19–65 BGCs (median=42.5) and varied even among members of the same Streptomyces species. Nine major classes of BGCs were detected in ten of the 11 bat species and in all sites: terpene, non-ribosomal peptide synthetase, polyketide synthase, siderophore, RiPP-like, butyrolactone, lanthipeptide, ectoine, melanin. Finally, Streptomyces genomes carry multiple hybrid BGCs consisting of signature domains from two to seven distinct BGC classes. Taken together, our results bring critical insights to understanding Streptomyces-bat ecology and BGC diversity that may contribute to bat health and in augmenting current efforts in natural product discovery, especially from underexplored or overlooked environments.

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Great diversity of KSα sequences from bat-associated microbiota suggests novel sources of uncharacterized natural products

et al. 2022

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Polyketide synthases (PKS) are multi-domain enzymes in microorganisms that synthesize complex, bioactive molecules. PKS II systems are iterative, containing only a single representative of each domain: ketosynthase alpha (KS$\alpha$), ketosynthase beta, and the acyl carrier protein. Any gene encoding for one of these domains is representative of an entire PKS II biosynthetic gene cluster (BGC). Bat skin surfaces represent an extreme environment prolific in Actinobacteria that may constitute a source for bioactive molecule discovery. KS$\alpha$ sequences were obtained from culturable bacteria from bats in the southwestern United States. From 467 bat bacterial isolates, we detected 215 (46%) had KS$\alpha$ sequences. Sequencing yielded 210 operational taxonomic units (OTUs), and phylogenetic placement found 45 (21%) shared less than 85% homology to characterized metabolites. Additionally, 16 Actinobacteria genomes from the bat microbiome were sequenced and analyzed for biosynthetic capacity. A range of 69% to 93% of the BGCs were novel suggesting the bat microbiome may contain valuable uncharacterized natural products. Documenting and characterizing these are important in understanding the susceptibility of bats to emerging infectious diseases, like white-nose syndrome. Also noteworthy was the relationship between KS$\alpha$ homology and total BGC novelty within each fully sequenced strain. We propose amplification and detection of KS$\alpha$ could predict a strain's global biosynthetic capacity.

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Streptomyces corynorhini sp. nov., isolated from Townsend’s big-eared bats (Corynorhinus townsendii)

Cited by 4 publications

References 28 publications

Streptomyces cahuitamycinicus sp. nov., isolated from desert soil and reclassification of Streptomyces galilaeus as a later heterotypic synonym of Streptomyces bobili

Streptomyces cahuitamycinicus sp. nov., isolated from desert soil and reclassification of Streptomyces galilaeus as a later heterotypic synonym of Streptomyces bobili

Ecology shapes the genomic and biosynthetic diversification of Streptomyces bacteria from insectivorous bats

Great diversity of KSα sequences from bat-associated microbiota suggests novel sources of uncharacterized natural products

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