1982
DOI: 10.1016/0006-2944(82)90082-5
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Streptozocin-induced diabetes decreases formation of prostacyclin from arachidonic acid in intact rat lungs

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Cited by 20 publications
(7 citation statements)
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“…Tissues from patients and animals with different forms of diabetes mellitus have been reported to produce less prostacyclin in vitro than tissues from their non-diabetic controls (Watts et al 1982;Lubawy & Valentovic, 1982;Roth et al, 1983). We were therefore surprised by the lack of marked effect of diabetics on prostacyclin release from perfused lung in the present study.…”
Section: Discussioncontrasting
confidence: 47%
See 1 more Smart Citation
“…Tissues from patients and animals with different forms of diabetes mellitus have been reported to produce less prostacyclin in vitro than tissues from their non-diabetic controls (Watts et al 1982;Lubawy & Valentovic, 1982;Roth et al, 1983). We were therefore surprised by the lack of marked effect of diabetics on prostacyclin release from perfused lung in the present study.…”
Section: Discussioncontrasting
confidence: 47%
“…Others have also noted a large withingroup variability in protacyclin release from isolated lung (Watts et al, 1982) and, against such a background, it is difficult to resolve differences between experimental groups. Previous studies have demonstrated reduced arachidonic acid (AA)-stimulated release of prostacyclin from perfused lungs of diabetic rats (Lubawy & Valentovic, 1982), albeit with a recirculating perfusion system which amplified differences. In another study using the lung, basal prostacyclin release was reduced, but AA-stimulated release, although numerically reduced, was not significantly different from control (Watts et al, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…In the pancreas a possible role for abnormalities of PG metabolism in the pathophysiology of impaired insulin secretion in diabetics has been inferred from the observation that PGE infusion inhibits glucose-induced acute insulin responses in normal human subjects and infusion of sodium salicylate partially restores the acute insulin response to glucose infusion in type II diabetics (48). Similarly, changes in PG metabolism in lung (49)(50)(51), heart (52), and seminal vesicles eluting at 26 min, co-migrated with both 8-HETE and HHT standards in this system. When this peak was collected and injected into a reverse-phase system, it was determined to be entirely HHT.…”
Section: Discussionmentioning
confidence: 99%
“…With regard to the kidney, previous studies demonstrate increased production of PGE2, 6-keto-PGFia, and TXB2 by glomeruli isolated from rats with early streptozotocin-induced diabetes mellitus (8,9,(11)(12)(13).…”
Section: Introductionmentioning
confidence: 98%
“…Diabetes mellitus in experimental animals and humans is associated with qualitative and quantitative changes in PG and TX production by many tissues (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). With regard to the kidney, previous studies demonstrate increased production of PGE2, 6-keto-PGFia, and TXB2 by glomeruli isolated from rats with early streptozotocin-induced diabetes mellitus (8,9,(11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%