Stress and atopic dermatitis

Arndt, Jenna; Smith, Nananamibia; Tausk, Francisco

doi:10.1007/s11882-008-0050-6

Cited by 138 publications

(128 citation statements)

References 54 publications

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“…Stressful life events are known to play an important role in the onset and aggravation of various dermatoses, namely psoriasis, vitiligo, alopecia aereata, lichen planus, atopic dermatitis [23][24][25][26]. In addition, the Iraqi health care system is still crippled by the conflicts in the country [27], which hinder the treatment of many health problems including dermatological ones.…”

Section: Discussionmentioning

confidence: 99%

Pattern of dermatoses in Iraqi children

Al‐Mendalawi¹,

Ibrahim²

2012

East Mediterr Health J

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The prevalence of paediatric dermatoses has risen in Iraq from 33.5% in 1987 to 40.9% in 2010. The objective of this study was to document the pattern of dermatoses in Iraqi children attending the outpatient clinic of a teaching hospital in Baghdad, Iraq. We conducted a cross-sectional study of 663 children under the age of 12 years who attended for dermatological consultation during 2008. The study showed that the prevailing dermatoses were as follow: infectious (32.3%), eczematous (20.8%), pigmentary (17.8%), papulosquamous (14.2%), drug-induced (4.5%), nutritional deficiency (1.8%) and miscellaneous (8.6%). The studied patterns of dermatoses were similar to that reported in other developing countries.

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Section: Discussionmentioning

confidence: 99%

Pattern of dermatoses in Iraqi children

Al‐Mendalawi¹,

Ibrahim²

2012

East Mediterr Health J

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“…In allergic disorders-especially in people with an atopic predisposition-the net effect of the stress response was generally reported to contribute to acute exacerbation and even onset of disease (2)(3)(4)(5)(6)(7). The key mechanisms involved are altered immune competence and neuronal plasticity after stress experience as a result of an HPA-and SA-generated Th2 bias on the one hand and local proinflammatory NNA activation on the other hand (8)(9)(10).…”

mentioning

confidence: 99%

Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation

Pavlović

Liezmann

Blois

et al. 2011

The Journal of Immunology

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Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic inflammation/noise stress model with C57BL/6 mice, we show in this paper that SP—released during repeated stress exposure—has the capacity to markedly attenuate inflammation. In particular, repeated stress exposure prior to allergen sensitization increases DC-nerve fiber contacts, enhances DC migration and maturation, alters cytokine balance, and increases levels of IL-2 and T regulatory cell numbers in local lymph nodes and inflamed tissue in a neurokinin 1-SP-receptor (neurokinin-1 receptor)-dependent manner. Concordantly, allergic inflammation is significantly reduced after repeated stress exposure. We conclude that SP/repeated stress prior to immune activation acts protolerogenically and thereby beneficially in inflammation.

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“…Stress enhances contact hypersensitivity through the activation of dendritic cells which is mediated by the release of norepinephrine from peripheral nerve fibers [99]. Moreover, stress is known to aggravate inflammation through neurogenic inflammation and mast cell degranulation [85,100,101], resulting in impaired skin barrier function [102]. It is especially interesting to note that stress directly induces the release of substance P in the skin, which worsens atopic dermatitis [103].…”

Section: Psychosomatic Consequences and The Role Of Stressmentioning

confidence: 99%

Atopic Dermatitis and the Nervous System

Miséry

2010

Clinic Rev Allerg Immunol

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Due to the narrow associations between the skin, immune system, and nervous system, nerve endings are very important in the pathophysiology of inflammatory dermatoses and especially in atopic dermatitis. Many neurotransmitters and nerve growth factors that are released in blood or skin are involved in neurogenic inflammation, which dramatically enhance the inflammation induced by immune cells. During times of stress, their release is highly enhanced. In atopic dermatitis lesions, there are many specific changes in skin neurobiology and neurophysiology. These interesting data suggest that novel therapeutic possibilities can be imagined.

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Stress and atopic dermatitis

Cited by 138 publications

References 54 publications

Pattern of dermatoses in Iraqi children

Pattern of dermatoses in Iraqi children

Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation

Atopic Dermatitis and the Nervous System

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