Stress and the brain: Emotional support mediates the association between myelination in the right supramarginal gyrus and perceived chronic stress

Guo, Yiqun; Dong, Debo; Zhou, Feng; Li, Zhangyong; Zhao, Lu; Long, Zhiliang

doi:10.1016/j.ynstr.2022.100511

Cited by 7 publications

(9 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As middle/deep levels were involved, feed forward and feed-back processes and intercortical and subcortical-cortical communication in these regions may be affected with worse ADI 32 . A previous study found that higher perceived stress was associated with lower T1w/T2w ratio in the right supramarginal gyrus 18 . However, in the present study, perceived stress was not significantly associated with decreased T1w/T2w ratio in ADI-negative areas, which included the left, but not the right, supramarginal gyrus.…”

Section: Discussionmentioning

confidence: 85%

“…Neighborhood disadvantage, high BMI, and chronic stress have also been shown to impact the cortical microstructure as assessed by the T1-weighted/T2-weighted (T1w/T2w) ratio and myelin content [16][17][18][19] . Intracortical myelination, which refers to the myelination of axons in the cortical gray matter, affects the timing and integration of signals from multiple axons, and is critical for neural synchrony and fine-tuning of cortical circuits, affecting cognitive functioning [20][21][22] .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index

Kilpatrick,

Zhang,

Dong

et al. 2023

Commun Med

View full text Add to dashboard Cite

Background Living in a disadvantaged neighborhood is associated with worse health outcomes, including brain health, yet the underlying biological mechanisms are incompletely understood. We investigated the relationship between neighborhood disadvantage and cortical microstructure, assessed as the T1-weighted/T2-weighted ratio (T1w/T2w) on magnetic resonance imaging, and the potential mediating roles of body mass index (BMI) and stress, as well as the relationship between trans-fatty acid intake and cortical microstructure. Methods Participants comprised 92 adults (27 men; 65 women) who underwent neuroimaging and provided residential address information. Neighborhood disadvantage was assessed as the 2020 California State area deprivation index (ADI). The T1w/T2w ratio was calculated at four cortical ribbon levels (deep, lower-middle, upper-middle, and superficial). Perceived stress and BMI were assessed as potential mediating factors. Dietary data was collected in 81 participants. Results Here, we show that worse ADI is positively correlated with BMI (r = 0.27, p = .01) and perceived stress (r = 0.22, p = .04); decreased T1w/T2w ratio in middle/deep cortex in supramarginal, temporal, and primary motor regions (p < .001); and increased T1w/T2w ratio in superficial cortex in medial prefrontal and cingulate regions (p < .001). Increased BMI partially mediates the relationship between worse ADI and observed T1w/T2w ratio increases (p = .02). Further, trans-fatty acid intake (high in fried fast foods and obesogenic) is correlated with these T1w/T2w ratio increases (p = .03). Conclusions Obesogenic aspects of neighborhood disadvantage, including poor dietary quality, may disrupt information processing flexibility in regions involved in reward, emotion regulation, and cognition. These data further suggest ramifications of living in a disadvantaged neighborhood on brain health.

show abstract

Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 99%

Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index

Kilpatrick,

Zhang,

Dong

et al. 2023

Commun Med

View full text Add to dashboard Cite

show abstract

“…Animal studies suggest that myelin plasticity is a major component in the response to stress 57 . In addition, a previous study using the T1w/T2w ratio as a measure of intracortical myelination found that higher perceived stress was associated with lower intracortical myelination in the right supramarginal gyrus 19 . However, in the present study, perceived stress was not signi cantly associated with decreased myelination in ADI-negative regions, which included the left supramarginal gyrus.…”

Section: Adi and Decreased Intracortical Myelinationmentioning

confidence: 94%

“…Neighborhood disadvantage, high BMI, and chronic stress have also been shown to impact intracortical myelination 17,18,19 . Intracortical myelination, which refers to the myelination of axons in the cortical gray matter, affects the timing and integration of signals from multiple axons, and is critical for neural synchrony and ne-tuning of cortical circuits, affecting cognitive functioning 20,21,22 .…”

Section: Introductionmentioning

confidence: 99%

Mediating role of obesity on the association between disadvantaged neighborhoods and intracortical myelination

Kilpatrick

Zhang

Dong

et al. 2023

Preprint

View full text Add to dashboard Cite

We investigated the relationship between neighborhood disadvantage (area deprivation index [ADI]) and intracortical myelination (T1-weighted/T2-weighted ratio at deep to superficial cortical levels), and the potential mediating role of the body mass index (BMI) and perceived stress in 92 adults. Worse ADI was correlated with increased BMI and perceived stress (p's<.05). Non-rotated partial least squares analysis revealed associations between worse ADI and decreased myelination in middle/deep cortex in supramarginal, temporal, and primary motor regions and increased myelination in superficial cortex in medial prefrontal and cingulate regions (p<.001); thus, neighborhood disadvantage may influence the flexibility of information processing involved in reward, emotion regulation, and cognition. Structural equation modelling revealed increased BMI as partially mediating the relationship between worse ADI and observed myelination increases (p=.02). Further, trans-fatty acid intake was correlated with observed myelination increases (p=.03), suggesting the importance of dietary quality. These data further suggest ramifications of neighborhood disadvantage on brain health.

show abstract

“…Over the past decade, a body of evidence has emerged suggesting that mental disorders are often accompanied by dysfunctional myelination changes, myelin sheath defects, and correlated alterations in white matter. This underlying pathology potentially compromises inter-neuronal information transfer, processing, and communication, which can feasibly culminate in behavioral, sensory-motor, affective, and cognitive symptoms manifesting in patients with mental disorders [7][8][9][10]. Numerous studies have additionally highlighted alterations in dopamine, serotonin, and glutamatergic neurotransmission in mental disorders, including, but not limited to, depression, cognitive disorders, and schizophrenia [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Brain Iron Homeostasis and Mental Disorders

Wu,

Ren,

Meng

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has not received significant attention. Therefore, our understanding of iron metabolism in the context of psychological diseases is incomplete. In this review, we aim to discuss the pathologies and potential mechanisms that relate to iron homeostasis in associated mental disorders. We propose the hypothesis that maintaining brain iron homeostasis can support neuronal physiological functions by impacting key enzymatic activities during neurotransmission, redox balance, and myelination. In conclusion, our review highlights the importance of investigating the relationship between trace element nutrition and the pathological process of mental disorders, focusing on iron. This nutritional perspective can offer valuable insights for the clinical treatment of mental disorders.

show abstract

Stress and the brain: Emotional support mediates the association between myelination in the right supramarginal gyrus and perceived chronic stress

Cited by 7 publications

References 119 publications

Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index

Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index

Mediating role of obesity on the association between disadvantaged neighborhoods and intracortical myelination

Brain Iron Homeostasis and Mental Disorders

Contact Info

Product

Resources

About