Stress and the Skin

Tausk, Francisco; Nousari, Hossein C.

doi:10.1001/archderm.137.1.78

Cited by 52 publications

(31 citation statements)

References 109 publications

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“…Many skin disorders, including psoriasis and atopic dermatitis, are initiated, exacerbated, or propagated by PS (20,31,35). The abnormalities in epidermal proliferation, epidermal differentiation, permeability barrier homeostasis, and SC integrity and cohesion could all contribute to the adverse effects of PS on cutaneous function.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the mechanistic basis for the decrease in SC integrity, i.e., a reduction in corneodesmosomes, is also normalized by inhibition of GC action. Thus many of the adverse effects of PS on epidermal structure and function can be attributed to increased endogenous GC and conversely, approaches that either reduce GC production or action might benefit cutaneous disorders that are provoked or exacerbated by PS.RU-486; corticotropin-releasing hormone; stratum corneum integrity; barrier homeostasis PSYCHOLOGICAL STRESS (PS) is well recognized to provoke, exacerbate, or propagate many cutaneous dermatoses, including psoriasis and atopic dermatitis (20,31,35). Many of the disorders that are adversely affected by PS are also associated with abnormal permeability barrier function (17, 18).…”

mentioning

confidence: 99%

“…PSYCHOLOGICAL STRESS (PS) is well recognized to provoke, exacerbate, or propagate many cutaneous dermatoses, including psoriasis and atopic dermatitis (20,31,35). Many of the disorders that are adversely affected by PS are also associated with abnormal permeability barrier function (17,18).…”

mentioning

confidence: 99%

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Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function

Choi¹,

Demerjian²,

Crumrine³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Recent studies have demonstrated that PS decreases epidermal proliferation and differentiation, impairs permeability barrier homeostasis, and decreases stratum corneum integrity. PS also increases the production of endogenous glucocorticoids (GC), and both systemic and topical GC cause adverse effects on epidermal structure and function similar to those observed with PS. We therefore hypothesized that increased endogenous GC in PS mediates its adverse cutaneous effects. To test this hypothesis, we used two independent approaches, administering either RU-486, a GC receptor antagonist that inhibits GC action, or antalarmin, a corticotropin-releasing hormone (CRH) receptor antagonist that prevents increased GC production in the face of PS. Inhibition of either GC action or production prevents the PS-induced decline in epidermal cell proliferation and differentiation, impairment in permeability barrier homeostasis, and decrease in stratum corneum (SC) integrity. Moreover, the pathophysiological basis for the abnormality in permeability barrier homeostasis; i.e., decreased lamellar body production and secretion, is restored toward normal by inhibition of GC action. Similarly, the mechanistic basis for the decrease in SC integrity, i.e., a reduction in corneodesmosomes, is also normalized by inhibition of GC action. Thus many of the adverse effects of PS on epidermal structure and function can be attributed to increased endogenous GC and conversely, approaches that either reduce GC production or action might benefit cutaneous disorders that are provoked or exacerbated by PS.RU-486; corticotropin-releasing hormone; stratum corneum integrity; barrier homeostasis PSYCHOLOGICAL STRESS (PS) is well recognized to provoke, exacerbate, or propagate many cutaneous dermatoses, including psoriasis and atopic dermatitis (20,31,35). Many of the disorders that are adversely affected by PS are also associated with abnormal permeability barrier function (17, 18). Studies in both rodents and human have demonstrated that PS perturbs permeability barrier homeostasis. While basal permeability barrier function is normal, the kinetics of barrier recovery following acute barrier disruption are delayed (2,7,8,16). This delay in barrier recovery is accounted for by a decrease in the production and secretion of lamellar bodies (LB) (5) with a resultant decrease in the formation of the extracellular lamellar membranes that mediate epidermal permeability barrier function (10). Epidermal lipid synthesis is essential for providing the lipids required for the formation of LB (11). Accordingly, the decrease in LB secretion in PS animals is explained by a decrease in epidermal lipid synthesis (5). Of note, the abnormality in barrier homeostasis induced by PS can be normalized by the topical applications of a mixture of barrier lipids, which normalize LB formation and secretion (5).In addition to adversely effecting barrier homeostasis, PS also decreases keratinocyte proliferation, impairs epidermal differentiation, and decreases stratum corneum (SC) ...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function

Choi¹,

Demerjian²,

Crumrine³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Researchers studied the infl uence of stress on skin barrier function. Stress negatively infl uences permeability barrier homeostasis-the balance between production and sloughing of corneocytes [ 33 ]. Stress also negatively affects stratum corneum integrity and cohesion, which may be infl uenced by increased circulating corticosteroid levels due to stress [ 34 ].…”

Section: Epidermal Barrier Dysfunctionmentioning

confidence: 99%

Stress and atopic dermatitis

Arndt¹,

Smith²,

Tausk

2008

Curr Allergy Asthma Rep

138

115

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Atopic dermatitis (AD) is a complex disease traditionally involving interaction of genetic, environmental, and immunologic factors. Recent studies suggest psycho-neuro-immunologic factors and emotional stress are important in its evolution. The observations that internal (bacterial infections) or external (psycho-logic) stressors may induce AD flares is explained by studies showing that stress impairs the skin barrier function and favors a shift in immunity toward a T helper type 2 cell/allergic response. Furthermore, those with AD appear to have an inherited hypothalamic deficiency that impairs normal hypothalamic-pituitary-adrenal axis function. Neuropeptides released in the skin may also mediate neurogenic inflammation, including mast cell degranulation. AD causes significant stress and impaired quality of life in patients and their family members. Psychologic and stress-reduction interventions were recently shown to improve patient well-being, and to significantly improve cutaneous manifestations.

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“…Este problema con la imagen corporal ha trascendido en el tiempo permitiendo demostrar las consecuencias negativas que tiene para un individuo, en la actualidad se ha demostrado bajo autoestima, problemas interpersonales de ansiedad dificultando la interacción social, problemas en las relaciones sexuales, problemas depresivos y desórdenes de la alimentación que cómo consecuencia pueden llevar a un procedimiento de cirugía plástica. (Montaño, 2006;Tausk & Nousari, 2001). …”

Section: Modificaciones Corporalesunclassified

Satisfacción de la imagen corporal en universitarios que cuenten con el 10% del cuerpo tatuado y universitarios no tatuados

Valderrama

Munévar

2015

Informes.psicol

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ResumenObjetivo: identificar la satisfacción de la imagen corporal en universitarios con mínimo el 10% de sus cuerpos tatuados y universitarios sin ningún tipo de modificación corporal. Método: estudio no experimental de diseño transaccional descriptivo, se realizó con una muestra de 34 universitarios tatuados (11 mujeres -23 hombres) y 82 universitarios sin modificaciones corporales (41 mujeres y 41 hombres) mayores de 20 años, residentes en Bogotá, vinculados a un programa de educación superior, sin ningún antecedente psiquiátrico y que no pertenecieran a ninguna tribu urbana o grupo social específico. Resultados: se evidenciaron diferencias significativas frente a la satisfacción general de la imagen corporal siendo los universitarios tatuados quienes presentan mayores puntajes. De igual manera, se halló que tanto las mujeres como los hombres con el 10% del cuerpo tatuado presentan diferencias significativas favorables de imagen corporal en relación a aquellas personas que no se han modificado. Conclusiones: se atribuye al tatuaje funcionalidad para el reconocimiento mental del cuerpo y la autoevaluación permitiendo tener un juicio valorativo más satisfactorio en el individuo sobre su imagen corporal. Satisfação da imagem corporal em universitários que contém com 10% do corpo tatuado e universitários não tatuados Satisfaction of body image in college students with 10% of their bodies tattooed and those who have not tattooed their body ResumoObjetivo: Identificar a satisfação da imagem corporal em universitários com mínimo de 10% de seus corpos tatuados e universitários sem nenhum tipo de modificação corporal. Método: Estudo não experimental de desenho transacional descritivo, se realizou com uma amostra de 34 universitários tatuados (11 mulheres -23 homens) e 82 universitários sem modificações corporais (41 mulheres e 41 homens) maiores de 20 anos, residentes em Bogotá, vinculados a um programa de educação superior, sem nenhum antecedente psiquiátrico e que não pertenceram a nenhuma tribo urbana ou grupo social específico. Resultados: Se evidenciaram diferencias significativas frente à satisfação geral da imagem corporal sendo os universitários tatuados quem apresentam maiores pontuações. De igual maneira, se encontrou que tanto as mulheres como os homens com 10% do corpo tatuado apresentam diferencias significativas favoráveis de imagem corporal em relação a aquelas pessoas que não se hão modificado. Conclusões: Se atribui à tatuagem funcionalidade para o reconhecimento mental do corpo e a auto-avaliação permitindo ter um juízo valorativo mais satisfatório no individuo sobre sua imagem corporal. Palavras chavesatisfação da imagem corporal, tatuagem, modificação corporal, estudantes universitários. AbstractAim: To identify the body image satisfaction in college students with at least 10% of their bodies tattooed and college students without any kind of body modification. Method: Non experimental study with a transactional descriptive design; it was conducted with a sample of 34 tattooed college students (11 w...

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Stress and the Skin

Cited by 52 publications

References 109 publications

Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function

Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function

Stress and atopic dermatitis

Satisfacción de la imagen corporal en universitarios que cuenten con el 10% del cuerpo tatuado y universitarios no tatuados

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