Stress, Cortisol, and Lymphocyte Subpopulations

Baker, Gertrude; Byrom, N.A.; Irani, Mohamad; Brewerton, D. A.; Hobbs, J.R.; Wood, R. J.; Nagvekar, N

doi:10.1016/s0140-6736(84)90981-4

Cited by 24 publications

(11 citation statements)

References 10 publications

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“…The secretion of salivary immunoglobulin A was found to be depressed before examination in a group of 64 dental students [22], and it was even lower in those who were judged to show an 'inhibited power motive' personality. During the first week in the hospital, medical students were anxious, they had increased serum cortisol and an increased proportion of T helper lymphocytes when compared to themselves a few months later [23]. The stress of the National Board Medical Examination produced a significant reduction in T lymphocyte polyclonal proliferation [24], and those students whose stress response was characterized by 'intrusion' were significantly more immunosuppressed than those characterized by an 'avoidance stress' response style.…”

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y Plasma Levels and Immunological Changes during Academic Stress

Guidi¹,

Tricerri²,

Vangeli³

et al. 1999

Neuropsychobiology

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Academic stress is a good model of psychological stress in humans for studying psychoneuroimmune correlations. We looked for correlations between psychological scores, immune tests and plasma levels of cortisol and neuropeptide Y (NPY). A group of medical students were evaluated at the beginning of the academic year (Baseline) and the day before an examination (Stress). They underwent evaluation by The Profile of Mood States (POMS), The Malaise Inventory, The Self Efficacy Scale and A Global Assessment of Recent Stress (GARS). The lymphocyte subsets, the lymphocyte proliferative response and the cytokine production were also evaluated. We detected modifications of some psychological test scores between the Baseline and Stress evaluation, a significant reduction of lymphocyte proliferation, IL-2 production and percentage of the lymphocyte CD19, and an increase in plasma cortisol levels during stress. The lymphocyte proliferation negatively correlated with the POMS score as well as the percentage of CD16+ cells with NPY plasma levels. NPY levels were not different from Baseline. The emotional and mood states seem to influence immunity.

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Section: Discussionmentioning

confidence: 99%

Neuropeptide Y Plasma Levels and Immunological Changes during Academic Stress

Guidi¹,

Tricerri²,

Vangeli³

et al. 1999

Neuropsychobiology

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“…Specifically, the relationship between cortisol and perceived stress is unclear, with existing literature depicting conflicting results (Pancheri and Biondi 1994). For example, Baker et al (1984) suggested a positive correlation between perceived stress and cortisol levels, while Ebrecht et al (2004) found no correlation between perceived stress and cortisol levels. Moreover, the relationship between examination stress and salivary-IgA (S-IgA) is also unclear.…”

Section: Introductionmentioning

confidence: 99%

Academic stress differentially influences perceived stress, salivary cortisol, and immunoglobulin-A in undergraduate students

Murphy

Denis

Ward

et al. 2010

Stress

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Academic examination stress is reported to increase physiological and self-report measures of stress and to decrease immune functioning. Here, we investigate biochemical and self-report measures of stress, immune functioning, and academic pressures before and during a midterm examination period. Undergraduate students were asked to complete a measure of global stress, the perceived stress scale (PSS-10), and to indicate their current level of perceived stress. They also answered questions regarding specific academic pressures and provided a saliva sample for cortisol and salivary immunoglobulin-A (S-IgA) quantification. Students showed increased salivary cortisol concentrations and also reported greater acute perceived stress during the examination period compared to the non-examination period. Although cortisol concentrations and perceived stress were significantly higher during the examination period, participants reported similar levels of global stress (PSS-10) during both testing sessions. Additional analyses showed a non-significant increase in the level of S-IgA from the non-examination period to the examination period. Specific pressure variables that appeared to contribute to stress regulation during the examination week included the amount of time spent studying and concern about the impact of examinations in the future. By demonstrating measures of chronic examination stress, these findings provide new insight into the complex relationship between examination stress, cortisol, and immune functioning.

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“…I n some studies, changes in the concentration of peripheral lymphocytes were found. Baker, Byrom, Irani, Brewerton, Hobbs, Wood and Nagvekar (1984) reported an increased percentage of helper cells (CD4+) in first year students ( N = 24) as compared to more advanced students ( N = 27). Kiecolt-Glaser et al (1986) found a lowered concentration of CD4+ cells and NKcells (Glaser et al, 1986a) in students before an exam and Halvorsen and Vassend (1987) got a reduced percentage of CD4 + and CD8 + cells in a subpopulation of large lymphocytes at this time.…”

Section: Studies On Examination Stressmentioning

confidence: 96%

Overview of psychoneuroimmunological stress‐ and intervention studies in humans with emphasis on the uses of immunological parameters

Schulz

1992

Psycho-Oncology

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Psychoneuroimmunological stress-and intervention studies are summarized and discussed especially with respect to the immunological parameters used. A description is given of the studies on bereavement, on examinations, and on the effects of various psychosocial situations and on experimental manipulations on immunological parameters as well as of intervention studies. Following an analysis of the immunological parameters regarding their susceptibility to psychosocial changes, a model for research in the field of psychoneuroimmunology is presented. This overview reveals that the results of the reviewed studies prove to be inconsistent. Cell counts and mitogen assays are the most frequently used parameters, while NKCA and specific anti-viral antibodies against latent viruses give the clearest results. When interpreting results of psychoneuroimmunological studies it should be considered that for most of the parameters the pathophysiological relevance is not yet established. A model which connects interrelations between psychosocial conditions, immunological parameters and disease outcome can be useful to categorize and evaluate existing and future studies and also can prevent misleading conclusions. Derived from this model recommendations for future research will be discussed.

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Stress, Cortisol, and Lymphocyte Subpopulations

Cited by 24 publications

References 10 publications

Neuropeptide Y Plasma Levels and Immunological Changes during Academic Stress

Neuropeptide Y Plasma Levels and Immunological Changes during Academic Stress

Academic stress differentially influences perceived stress, salivary cortisol, and immunoglobulin-A in undergraduate students

Overview of psychoneuroimmunological stress‐ and intervention studies in humans with emphasis on the uses of immunological parameters

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