Stress decreases contraction of the colon, and the effects of stress are          different among the regions of the colon

Ono, Naoshige; Suzuki, Sho; Kawada, Koichi; Yamaguchi, Taro; Azuma, Yukio

doi:10.1292/jvms.22-0073

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Our findings were supported by previous studies in which stress altered the gastrointestinal (GI) motility and induced changes in the secretions, intestinal barrier permeability, and gut microbiota [7]. A study on mice subjected to water-immersion stress reported a reduction in longitudinal contractions of both the proximal and distal colon [19]. Restrained C57BL/6 mice exhibited a diarrhea-like phenotype by increased motility [20].…”

Section: Discussionsupporting

confidence: 89%

Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae

Lee,

Kim,

Kang

et al. 2024

IJMS

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The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically Bifidobacterium longum (B. longum), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of aquaporins and vasoactive intestinal peptide, crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically B. longum, ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut–brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies.

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Section: Discussionsupporting

confidence: 89%

Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae

Lee,

Kim,

Kang

et al. 2024

IJMS

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“…Previous studies showed that colon length was reduced in mice with increased stress (Ono et al, 2022) and colitis (Ren et al, 2011;Wen et al, 2013;Zhang et al, 2018b). Thus, we investigated the correlation between oxidative stress and ASD modeling by estimating intracellular ROS levels in the blood cells using ROSsensitive dye, DCFH-DA, with full wavelength fluorometric enzyme labeler, for three consecutive days after inducing SD.…”

Section: Sx Alleviates Asd-induced Oxidative Stressmentioning

confidence: 99%

Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling

Wang

Zhang

et al. 2023

Front. Pharmacol.

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Introduction: Sleep disorders are common clinical psychosomatic disorders that can co-exist with a variety of conditions. In humans and animal models, sleep deprivation (SD) is closely related with gastrointestinal diseases. Shu-Xie Decoction (SX) is a traditional Chinese medicine (TCM) with anti-nociceptive, anti-inflammatory, and antidepressant properties. SX is effective in the clinic for treating patients with abnormal sleep and/or gastrointestinal disorders, but the underlying mechanisms are not known. This study investigated the mechanisms by which SX alleviates SD-induced colon injury in vivo.Methods: C57BL/6 mice were placed on an automated sleep deprivation system for 72 h to generate an acute sleep deprivation (ASD) model, and low-dose SX (SXL), high-dose SX (SXH), or S-zopiclone (S-z) as a positive control using the oral gavage were given during the whole ASD-induced period for one time each day. The colon length was measured and the colon morphology was visualized using hematoxylin and eosin (H&E) staining. ROS and the redox biomarkers include reduced glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) were detected. Quantitative real-time PCR (qRT-PCR), molecular docking, immunofluorescence and western blotting assays were performed to detect the antioxidant signaling pathways.Results: ASD significantly increased FBG levels, decreased colon length, moderately increased the infiltration of inflammatory cells in the colon mucosa, altered the colon mucosal structure, increased the levels of ROS, GSH, MDA, and SOD activity compared with the controls. These adverse effects were significantly alleviated by SX treatment. ASD induced nuclear translocation of NRF2 in the colon mucosal cells and increased the expression levels of p62, NQO1, and HO1 transcripts and proteins, but these effects were reversed by SX treatment.Conclusion: SX decoction ameliorated ASD-induced oxidative stress and colon injury by suppressing the p62/KEAP1/NRF2/HO1/NQO1 signaling pathway. In conclusion, combined clinical experience, SX may be a promising drug for sleep disorder combined with colitis.

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“…With regard to the underlying molecular and neurochemical changes of the neuromuscular apparatus, studies in mice have shown that chronic water immersion stress (3 h, 7 days and 13 days) reduced colonic and ileal contractions (Azuma et al., 2021; Ono et al., 2022). Additionally, chronic water‐avoidance stress (1 h, 9 days) increased spontaneous and inhibitory junction potentials in the colon (Reed et al., 2016), thereby increasing inhibitory neuromuscular transmission.…”

Section: The Stress Response: From Adaptation To Diseasementioning

confidence: 99%

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

Leigh,

Uhlig,

Wilmes

et al. 2023

The Journal of Physiology

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The physiological consequences of stress often manifest in the gastrointestinal tract. Traumatic or chronic stress is associated with widespread maladaptive changes throughout the gut, although comparatively little is known about the effects of acute stress. Furthermore, these stress‐induced changes in the gut may increase susceptibility to gastrointestinal disorders and infection, and impact critical features of the neural and behavioural consequences of the stress response by impairing gut–brain axis communication. Understanding the mechanisms behind changes in enteric nervous system circuitry, visceral sensitivity, gut barrier function, permeability, and the gut microbiota following stress is an important research objective with pathophysiological implications in both neurogastroenterology and psychiatry. Moreover, the gut microbiota has emerged as a key aspect of physiology sensitive to the effects of stress. In this review, we focus on different aspects of the gastrointestinal tract including gut barrier function as well as the immune, humoral and neuronal elements involved in gut–brain communication. Furthermore, we discuss the evidence for a role of stress in gastrointestinal disorders. Existing gaps in the current literature are highlighted, and possible avenues for future research with an integrated physiological perspective have been suggested. A more complete understanding of the spatial and temporal dynamics of the integrated host and microbial response to different kinds of stressors in the gastrointestinal tract will enable full exploitation of the diagnostic and therapeutic potential in the fast‐evolving field of host–microbiome interactions. image

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Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon

Cited by 3 publications

References 16 publications

Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae

Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae

Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

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