Stress decreases lymphocyte cytolytic activity in the young monkey even after blockade of steroid and opiate hormone receptors

Coe, Christopher L.; Erickson, Chris M.

doi:10.1002/(sici)1098-2302(199701)30:1<1::aid-dev1>3.0.co;2-w

Cited by 29 publications

(9 citation statements)

References 34 publications

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“…Thus, the additional magnesium supplement in diets (3% magnesium in HC) might cause some positive effects on reducing stress in pigs. Cortisol produced during stress situations may suppress the body's immune response (Coe, 1997), and higher level of cortisol in the bloodstream had been shown to have negative effects, such as lowered immunity (Suzanne and Gregory, 2004). The immunomodulatory effect of semen Plantaginis and radix Achyranthis bidentatae were shown in many previous researches (e.g., Chiang et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The effects of dietary herbs and coral mineral complex on growth performance, nutrient digestibility, blood characteristics and meat quality in finishing pigs

Wang

Chen²,

Cho³

et al. 2007

J. Anim. Feed Sci.

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Eighty crossbred pigs of initial mean body weight 58 kg were used to evaluate the effect of supplemental herbs and coral mineral complex (HC) on growth performance, nutrient digestibility, blood characteristics and meat quality in a 8 weeks growth trial. Pigs were randomly allocated to 4 treatments, which comprised: 1. control, 2. HC 0.05%, 3. HC 0.1%, and 4. HC 0.2%, respectively (4 pigs/pen, 5 replicates/treatment). Gain/feed linearly increased during week 4-8 (P<0.05) and overall period (P<0.10) with increasing HC level. Digestibility of DM and N during week 0-4 increased linearly with an increasing HC level (P<0.005). Serum IgG concentrations linearly increased with the increase of HC supplementation (P<0.01). Cortisol concentrations tended (P<0.10) to decrease linearly with increasing level of HC. The linear reduction of subjective scores for marbling (P<0.01) and firmness (P<0.01) of the longissimus muscle were observed. In conclusion, supplementation of HC improved feed efficiency and increased IgG and cortisol concentration in serum.

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Section: Discussionmentioning

confidence: 99%

The effects of dietary herbs and coral mineral complex on growth performance, nutrient digestibility, blood characteristics and meat quality in finishing pigs

Wang

Chen²,

Cho³

et al. 2007

J. Anim. Feed Sci.

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“…Cells were plated at a concentration of 2 ϫ 10 6 cells/ml in triplicate onto 24-well culture plates. Cells were then stimulated with Con A (Sigma-Aldrich) at 5 g/ml (a concentration determined to have significant stimulatory effect) and incubated overnight at 37 o C in 5% CO 2 .…”

Section: Tissue Culturementioning

confidence: 99%

Morphine Withdrawal Contributes to Th Cell Differentiation by Biasing Cells Toward the Th2 Lineage

Kelschenbach

Barke

Roy

2005

The Journal of Immunology

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The consequences that drug withdrawal has on immune functioning has only recently been appreciated; however, given the wide variety of use and abuse of opiate analgesics, understanding the decrements to immune function that withdrawal from these drugs causes is of crucial importance. In previous work, we have demonstrated that morphine treatment contributes to immunosuppression by polarizing Th cells toward the Th2 lineage. In the current study, it was hypothesized that morphine withdrawal would result in Th2 differentiation and subsequent immune dysfunction. To address this hypothesis, mice were chronically treated with morphine for 72 h followed by a 24-h withdrawal period. It was determined that 24-h morphine withdrawal resulted in a decrease in IFN-γ, the Th1 signature cytokine, whereas the Th2 cytokine, IL-4, was increased. In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3. In addition, the consequence of morphine withdrawal in the presence of an immune stimulation was also examined by treating mice in vivo with LPS before morphine withdrawal. Following withdrawal, it was found that the Th1-polarizing cytokine IL-12 was significantly decreased, providing further support for the observation that withdrawal results in Th2 differentiation by possibly impacting the generation of an appropriate innate immune response which directs subsequent adaptive Th1/Th2 responses.

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“…It is well documented that stress can suppress the immune system (Black 1994;Coe and Erickson 1997;Kling et al 1992;Padgett and Glaser 2003). For example, the stress of social separation in capuchin monkeys (Cebus apella) causes a decrease in immune function (Kling et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Do Nematode Infections of Red Colobus (Procolobus rufomitratus) and Black-and-White Colobus (Colobus guereza) on Humanized Forest Edges Differ from Those on Nonhumanized Forest Edges?

Hodder

Chapman

2012

Int J Primatol

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Forested edges, especially those that border humanized landscapes, provide opportunities for nonhuman primates and people to interact, and such interactions are predicted to alter disease dynamics. Given the rapid expansion of edge habitats globally, understanding changes occurring on edges is important in evaluating primate behavioral ecology and developing conservation plans. Our research investigates predictions concerning how gastrointestinal parasite and stress levels (cortisol) in red colobus and black-and-white colobus (Procolobus rufomitratus; Colobus guereza) in Kibale National Park, Uganda, differ between humanized and nonhumanized forest edges. We found Trichuris sp., an unidentified strongyle, and Strongyloides sp. in the fecal samples. Results did not generally support our expectation that humanized forest edges increase parasite infection and, counter to what we predicted, fecal cortisol did not differ between habitats, suggesting that proximity to edges and/or to humans did not result in increased stress. We conclude that broad habitat classifications, e.g., "humanized," may be too general to identify consistent differences in parasite infection, as other factors, specific to the parasite (e.g., life cycled), host (e.g., immune systems strength), or environment (e.g., moisture level), likely also play important roles.

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Stress decreases lymphocyte cytolytic activity in the young monkey even after blockade of steroid and opiate hormone receptors

Cited by 29 publications

References 34 publications

The effects of dietary herbs and coral mineral complex on growth performance, nutrient digestibility, blood characteristics and meat quality in finishing pigs

The effects of dietary herbs and coral mineral complex on growth performance, nutrient digestibility, blood characteristics and meat quality in finishing pigs

Morphine Withdrawal Contributes to Th Cell Differentiation by Biasing Cells Toward the Th2 Lineage

Do Nematode Infections of Red Colobus (Procolobus rufomitratus) and Black-and-White Colobus (Colobus guereza) on Humanized Forest Edges Differ from Those on Nonhumanized Forest Edges?

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