Stress decreases the serum level of osteocalcin

Napal, J.; Amado, J A; Riancho, José A.; Olmos, José M.; González‐Macías, Jesús

doi:10.1016/s0169-6009(08)80013-x

Cited by 41 publications

(20 citation statements)

References 13 publications

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“…Increased bone resorption led to hypercalcemia, which inhibited PTH secretion and consequently synthesis of 1,25-[OH] 2 D. Acutely, immobilization (high Rankin score) induced otherwise 'uncoupled' increases in bone turnover markers. Serum BGP concentrations reportedly decrease in situations representing biologic stress such as fracture or elective abdominal surgery [16]. Local fracture-related changes cannot be dismissed, given that bone loss and increased bone turnover are known to follow distal forearm [17] and ankle [18] fractures, where maximal increases in bone resorption markers occur between 2 and 6 weeks followed by normalization at 1 year [17,18].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Changes in Bone and Calcium Metabolism Following Hip Fracture in Elderly Patients

et al. 2001

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Although hip fracture is one of the most common causes of acute immobilization in elderly patients, little is known about the influence of immobilization on changes in bone and calcium metabolism following this event. We therefore compared serum biochemical indices of bone and calcium metabolism in 20 elderly subjects with hip fracture with those measured in 20 healthy age-matched controls. Rankin scores, a measure of functional dependence with 0 representing independence and 5 representing total dependence, were assigned. We also examined serial changes in these biochemical indices from shortly following the fracture to the early recovery period. Ionized calcium, intact parathyroid hormone (PTH), intact bone Gla protein (BGP), pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), 25-hydroxyvitamin D (25-OHD), and 1,25-dihydroxyvitamin D (1,25-[OH]2D) were measured. One week after the fracture, mean serum concentrations of calcium and ICTP were elevated in correspondence to degree of immobilization (mean Rankin score; 4.4), while serum concentrations of BGP, PTH, 25-OHD, and 1,25-[OH]2D were depressed. Rankin score (mean: 4.4) correlated positively with ICTP and negatively with BGP at this time. At 2 months, calcium and ICTP elevation decreased and BGP, PTH and 1,25-[OH]2D were less depressed, coinciding with a decline in Rankin score from 4.2 to 2.2. Indices were further improved at 3 months (mean Rankin score, 1.3), with calcium and BGP returning to normal. We concluded that increased bone resorption, and decreased bone formation, and hypercalcemia are present by 1 week following the hip fracture, and some resorption increase persists for at least 3 months. These changes could explain in part the high risk of another hip fracture.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Changes in Bone and Calcium Metabolism Following Hip Fracture in Elderly Patients

et al. 2001

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“…However, TALP is a somewhat insensitive marker of bone formation because variations in the concentration of the hepatic isoenzyme can mask changes in bone production. Osteocalcin has been shown to fall rapidly after trauma and physiological stress [25,26], probably as a consequence of rising serum cortisol, and this could explain the apparently normal values found in these fracture patients. The concentrations of BSAP and of hydroxyproline were both significantly elevated.…”

Section: Discussionmentioning

confidence: 99%

Colles' Fracture of the Wrist as an Indicator of Underlying Osteoporosis in Postmenopausal Women: A Prospective Study of Bone Mineral Density and Bone Turnover Rate

Earnshaw

Cawte

Worley

et al. 1998

Osteoporosis International

180

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Colles' fracture has been shown to be associated with an increased risk of hip fracture. The incidence of low bone mineral density (BMD) and high bone turnover in such patients is uncertain. The aim of this study was to prospectively assess BMD and bone turnover in a cohort of consecutive postmenopausal Colles' fracture patients. BMD (spine, hip and contralateral radius) was measured by dual-energy X-ray absorptiometry (DXA) within 2 weeks of fracture. Bone turnover was assessed within 4 days by measurement of serum osteocalcin, total alkaline phosphatase (TALP), bone-specific alkaline phosphatase (BSAP) and urine hydroxyproline. We recruited 106 (71%) of 149 consecutive patients. Fifty-one per cent of subjects had a history of previous fracture, and 25% a past history of wrist, hip or vertebral body fracture. The incidence of osteoporosis was 21%, 42% and 22% at the spine, hip and radius respectively. Fifty per cent of subjects had osteoporosis of at least one of these sites. When compared with the values expected for their age the patients were found to have higher BMD than expected at the spine, and slightly lower BMD at the hip and distal radius. Patients aged 65 years or less had lower hip BMD than expected from the age-matched normal range (p < 0.01). Osteocalcin and TALP levels did not differ from the normal ranges, but BSAP and hydroxyproline levels were significantly elevated (p < 0.001), with 37% and 25% of patients having levels above the respective normal ranges. We conclude that osteoporosis is common in patients with Colles' fracture; however, in older patients BMD is not lower than would be expected in the normal population. In patients aged 65 years or less BMD is lower than expected at the hip. Bone turnover rate is high in many such patients. Intervention to prevent future fracture would be appropriate in women aged 65 years or less with Colles' fracture.

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“…A regulatory role for pOC in extra-skeletal physiology was suggested by the stimulus specific alteration in pOC documented in humans (Fujita et al 1999;Napal et al 1993), monkeys (Hotchkiss et al 1998), and rodents (Fujita et al 1999;Hotchkiss et al 1998;Napal et al 1993;Patterson-Buckendahl et al 1995, 1988. These stimuli include those that also increase synthesis and secretion of glucocorticoids (cortisol or corticosterone; CS) and the catecholamine neurotransmitters norepinephrine (NE) and epinephrine (Epi).…”

Section: Introductionmentioning

confidence: 99%

Decreased Sensory Responses in Osteocalcin Null Mutant Mice Imply Neuropeptide Function

et al. 2012

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Osteocalcin, the most abundant member of the family of extracellular mineral binding gamma-carboxyglutamic acid proteins is synthesized primarily by osteoblasts. Its affinity for calcium ions is believed to limit bone mineralization. Several of the numerous hormones that regulate synthesis of osteocalcin, including glucocorticoids and parathyroid hormone, are also affected by stressful stimuli that require energy for an appropriate response. Based on our observations of OC responding to stressful sensory stimuli, the expression of OC in mouse and rat sensory ganglia was confirmed. It was thus hypothesized that the behavioral responses of the OC knockout mouse to stressful sensory stimuli would be abnormal. To test this hypothesis, behaviors related to sensory aspects of the stress response were quantified in nine groups of mice, aged 4-14 months, comparing knockout with their wild-type counterparts in six distinctly different behavioral tests. Resulting data indicated the following statistically significant differences: open field grooming frequency following saline injection, wild-type > knockout; paw stimulation with Von Frey fibers, knockout < wild-type; balance beam, knockout mobility < WT; thermal sensitivity to heat (tail flick), knockout < wild-type; and cold, knockout < wild-type. Insignificant differences in hanging wire test indicate that these responses are unrelated to reduced muscle strength. Each of these disparate environmental stimuli provided data indicating alterations of responses in knockout mice that suggest participation of osteocalcin in transmission of information about those sensory stimuli.

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Stress decreases the serum level of osteocalcin

Cited by 41 publications

References 13 publications

RETRACTED ARTICLE: Changes in Bone and Calcium Metabolism Following Hip Fracture in Elderly Patients

RETRACTED ARTICLE: Changes in Bone and Calcium Metabolism Following Hip Fracture in Elderly Patients

Colles' Fracture of the Wrist as an Indicator of Underlying Osteoporosis in Postmenopausal Women: A Prospective Study of Bone Mineral Density and Bone Turnover Rate

Decreased Sensory Responses in Osteocalcin Null Mutant Mice Imply Neuropeptide Function

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