Stress differentially modulates mRNA expression for corticotrophin-releasing hormone receptors in hypothalamus, hippocampus and pituitary of prairie voles

Pournajafi-Nazarloo, Hossein; Partoo, Leila; Sanzenbacher, Lisa; Paredes, Jamespaul; Hashimoto, Kozo; Azizi, Fereidoun; Carter, C. Sue

doi:10.1016/j.npep.2008.12.002

Cited by 23 publications

(21 citation statements)

References 43 publications

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“…In prairie voles, social separation from a same-sex conspecific does not seem to alter basal corticosterone concentrations, even during periods of isolation (Grippo et al, 2007a; Pournajafi-Nazarloo et al, 2009). However, basal corticosterone levels in circulation are higher in prairie voles housed with a same-sex conspecific compared to pair-bonded voles (Campbell et al, 2009).…”

Section: Hpa Axis and Stress-related Psychopathologiesmentioning

confidence: 93%

“…For example, individual housing can lead to an increased HPA axis and depression- and anxiety-like behavioral response to acute stressors (e.g., open field, elevated plus maze, forced swim, and sucrose preference tests) compared to social housing in monogamous rodents such as prairie voles ( Microtus ochrogaster ) (Stowe et al, 2005; Grippo et al, 2007a; Grippo et al, 2007b; Grippo et al, 2007c; Grippo et al, 2008; Grippo et al, 2009; Pournajafi-Nazarloo et al, 2009; Lieberwirth et al, 2011). In addition, when prairie voles lack a pair-bond, the rewarding properties of substances of abuse, such as amphetamine, are enhanced, even when they are housed with a same-sex conspecific (Liu et al, 2011; see Piazza and Le Moal, 1998 for a review on HPA axis-mediated substance use and abuse).…”

Section: Hpa Axis and Stress-related Psychopathologiesmentioning

confidence: 99%

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Salubrious effects of oxytocin on social stress-induced deficits

Smith

Wang

2012

Hormones and Behavior

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Social relationships are a fundamental aspect of life, affecting social, psychological, physiological, and behavioral functions. While social interactions can attenuate stress and promote health, disruption, confrontations, isolation, or neglect in the social environment can each be major stressors. Social stress can impair the basal function and stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis, impairing function of multiple biological systems and posing a risk to mental and physical health. In contrast, social support can ameliorate stress-induced physiological and immunological deficits, reducing the risk of subsequent psychological distress and improving an individual's overall well-being. For better clinical treatment of these physiological and mental pathologies, it is necessary to understand the regulatory mechanisms of stress-induced pathologies as well as determine the underlying biological mechanisms that regulate social buffering of the stress system. A number of ethologically relevant animal models of social stress and species that form strong adult social bonds have been utilized to study the etiology, treatment, and prevention of stress-related disorders. While undoubtedly a number of biological pathways contribute to the social buffering of the stress response, the convergence of evidence denotes the regulatory effects of oxytocin in facilitating social bond-promoting behaviors and their effect on the stress response. Thus, oxytocin may be perceived as a common regulatory element of the social environment, stress response, and stress-induced risks on mental and physical health.

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Section: Hpa Axis and Stress-related Psychopathologiesmentioning

confidence: 93%

Section: Hpa Axis and Stress-related Psychopathologiesmentioning

confidence: 99%

Salubrious effects of oxytocin on social stress-induced deficits

Smith

Wang

2012

Hormones and Behavior

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“…In these rats, social dysfunction was associated with enhanced CRH receptor 1 (CRHR1) expression in the hippocampus and the central nucleus of the amygdala, and treatment with a CRHR1 antagonist prevented the social dysfunctions 144 . Changes in the extrahypothalamic CRH system have also been observed after stress exposure in other developmental periods in rats 145,146 and prairie voles 147 , but their role in the associated changes in social behavior has not been explored. Interestingly, antagonizing brain CRH receptors reduced acute stress-induced fighting in rats 148 , decreased the expression of social defeat-induced submissive behavior in hamsters 149 and reversed passive stress coping behavior observed in male prairie voles separated from their female partners 150 .…”

Section: Extrahypothalamic Corticotropin Releasing Hormone (Crh)mentioning

confidence: 99%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

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“…Vole behavior and physiology is acutely attuned to alterations to the social environment or other environmental cues. In fact, a number of recent studies have denoted that the absence of social contact in prairie voles can promote a disruption to normal HPA axis activity and behavioral routines that mimic symptomatology of depression and anxiety disorders in humans (Stowe et al 2005; Grippo et al 2007b; Grippo et al 2007c; Grippo et al 2007a; Grippo et al 2008; Grippo et al 2009; Pournajafi-Nazarloo et al 2009; Lieberwirth et al 2012). In addition, prairie vole pair bonding facilitates a significant reduction in basal HPA axis activity (DeVries et al 1995; Carter et al 1997; DeVries et al 1997b), while separation from a bonded-partner can increase plasma corticosterone concentrations (Bosch et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Behavioral and physiological responses of female prairie voles (Microtus ochrogaster) to various stressful conditions

Smith

Lieberwirth

Wang

2013

Stress

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Stressful life events elicit hypothalamic-pituitary-adrenal (HPA) axis activation, which may alter psychological states or behavioral routines. Therefore, the current study focused on the HPA axis response to better understand such manifestations in female prairie voles (Microtus ochrogaster). In Experiment 1, females were stressed for 1 h via one of four stressors: exposure to a novel environment, immobilization (‘plastic mesh’), brief social defeat, or prolonged social defeat. Following a 30 min recovery, the females received a 5-min elevated plus maze (EPM) test and, subsequently, blood was collected to measure plasma corticosterone concentrations. Only immobilization stress induced an anxiety-like behavioral response in the EPM test and elevated plasma corticosterone levels compared to the control groups. Corticosterone concentrations were also significantly elevated following exposure to prolonged social defeat compared to the control conditions, but not after novel environment stress or short social defeat. In Experiment 2, females were exposed to immobilization stress over 1, 3, or 7 days in a daily (predictable; pIMO) or irregular (unpredictable; uIMO) schedule. The biobehavioral stress response in females exposed to pIMO for 3 or 7 days did not differ significantly from controls, suggesting these females habituated. By comparison, females exposed to uIMO over 3 or 7 days did not habituate behaviorally or physiologically, even producing augmented corticosterone levels. In both experiments, positive correlations were found between corticosterone levels and anxiety-like behaviors in the EPM test. Together, our data suggest that the stress response by female prairie voles is dependent on stress intensity, source, previous experience, and predictability. Furthermore, the HPA axis response, as evident by corticosterone levels, is associated with the impact that these factors have on behavioral routine.

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Stress differentially modulates mRNA expression for corticotrophin-releasing hormone receptors in hypothalamus, hippocampus and pituitary of prairie voles

Cited by 23 publications

References 43 publications

Salubrious effects of oxytocin on social stress-induced deficits

Salubrious effects of oxytocin on social stress-induced deficits

Stress and the social brain: behavioural effects and neurobiological mechanisms

Behavioral and physiological responses of female prairie voles (Microtus ochrogaster) to various stressful conditions

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