Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex

Muhammad, Arif; Carroll, Cathryn A.; Kolb, Bryan

doi:10.1016/j.neuroscience.2012.04.041

Cited by 125 publications

(92 citation statements)

References 38 publications

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“…Our interpretation that the observed mature-like negative amygdala-mPFC connectivity in PI children evidences accelerated development is supported by rodent models that have demonstrated causal relationships between maternal absence and acceleration of amygdala-mPFC phenotypes (5,15,17). Research in normative human development has shown that regulatory connections between the amygdala and mPFC manifest as positive coupling in childhood and shift to a mature pattern of negative coupling during adolescence (28).…”

Section: Discussionsupporting

confidence: 55%

“…For example, maternal deprivation results in the early emergence of adult-like fear learning based in frontoamygdala circuitry (5) and earlier emergence of amygdala function (8,15) and structural maturation (16). Maternal separation has also been associated with increased development of neurons in mPFC (17). Such changes can lead to adult-like fear extinction learning and mPFC-mediated down-regulation of the amygdala, even though as a group, these stressed animals can be more fearful and anxious (18).…”

mentioning

confidence: 99%

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Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation

Gee¹,

Gabard-Durnam²,

Flannery³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

756

742

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Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivation. Previously institutionalized youths, who experienced early maternal deprivation, exhibited atypical amygdalamPFC connectivity. Specifically, unlike the immature connectivity (positive amygdala-mPFC coupling) of comparison children, children with a history of early adversity evidenced mature connectivity (negative amygdala-mPFC coupling) and thus, resembled the adolescent phenotype. This connectivity pattern was mediated by the hormone cortisol, suggesting that stress-induced modifications of the hypothalamic-pituitary-adrenal axis shape amygdala-mPFC circuitry. Despite being age-atypical, negative amygdala-mPFC coupling conferred some degree of reduced anxiety, although anxiety was still significantly higher in the previously institutionalized group. These findings suggest that accelerated amygdala-mPFC development is an ontogenetic adaptation in response to early adversity.fMRI | emotion regulation | stress | neurodevelopment

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Section: Discussionsupporting

confidence: 55%

mentioning

confidence: 99%

Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation

Gee¹,

Gabard-Durnam²,

Flannery³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

756

742

View full text Add to dashboard Cite

show abstract

“…Studies in humans have described that prenatal stress predisposes to the offspring of stressed mothers, to suffer cardiovascular alterations, cognitive or emotional problems, among others (Talge et al, 2007). In other studies, it has been observed that under conditions of chronic prenatal stress, alterations in neuronal morphology are generated (Muhammad et al, 2012) and behavior of offspring (de Weerth et al, 2003). This evidence supports Barker's fetal programming theory (Barker, 1998), which describes the existence of critical developmental periods, which are different and specific for each tissue during fetal development (Chrousos, 2009), where a stimulus or a injury at some critical period could trigger long-term or lifetime effects on offspring.…”

Section: Introductionsupporting

confidence: 66%

Effects of Prenatal Stress on Conduction Airway Morphology

et al. 2018

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HENRÍQUEZ, R.; LAMOZA, K.; SOTO, N.; LOBOS, F. & ARAYA, M. Efectos del estrés prenatal sobre la morfología de la vía aérea de conducción. Int. J. Morphol., 36(1):319-326, 2018. RESUMEN:Se sabe que el estrés crónico gestacional altera la respuesta inmune pulmonar, predisponiendo a patologías cróni-cas pulmonares como el asma, que cursan con alteraciones morfológicas tanto en la vía aérea de conducción como de intercambio. Sin embargo, se desconoce aún si el estrés crónico gestacional genera alteraciones en la morfología pulmonar, específicamente en la vía aérea de conducción, que predisponga a hiperreactividad u otras alteraciones de la vía aérea, en etapas postnatales tempranas. El objetivo de este trabajo consistió en analizar los efectos del estrés prenatal sobre el desarrollo de la vía aérea de conducción pulmonar. Ocho hembras preñadas fueron divididas aleatoriamente en un grupo control y otro grupo sometido a estrés por restricción de movimiento durante la última semana gestacional. Las crías fueron sacrificadas en los días postnatal 0 (P0) y 14 (P14), extrayendoles el pulmón para realizar un análisis histomorfológico de la vía aérea de conducción. En P0 se observó en la vía aérea de conducción un aumento en la musculatura lisa peribronquiolar en machos estresados en comparación al control (p=0,0002). No se observaron diferencias significativas en la crías hembra, ni en la etapa de P14. El estrés prenatal produce cambios histomorfológicos en la vía aérea de conducción en las crías de hembras estresadas, en etapas postnatales tempranas.

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“…For instance, studies have demonstrated that both prenatal and postnatal stress in animals heightens the complexity of dendritic morphology of the accumbens, altering the branching, length, and spine density of the medium spiny neurons [26,27,28]. Functionally, in humans, the NAc appears to have adult-like response patterns in adolescence, whereas differences can still be observed in the prefrontal cortex and the dorsal striatum [29,30].…”

Section: Embryologymentioning

confidence: 99%

The Nucleus Accumbens: A Comprehensive Review

Salgado

Kaplitt²

2015

Stereotact Funct Neurosurg

398

289

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There is increasing interest among functional neurosurgeons in the potential for novel therapies to impact upon diseases beyond movement disorders and pain. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction. As such, focal modulation of the biology of the NAc with deep brain stimulation or novel biological therapies such as gene therapy or cell transplantation could have a major impact upon disorders such as depression and drug addiction. In order to both develop appropriate therapies and then deliver them in an effective fashion, a thorough understanding of the biology, physiology, and anatomy of the NAc is critical. Here, we review the existing literature regarding several areas critical to the development of new therapies, including the known pharmacology, physiology, and connectivity of the NAc, as well as evidence supporting the potential for various NAc surgical therapies in animal models. We then review the relevant anatomy of the NAc, with particular attention to the surgical anatomy, imaging, and targeting necessary to facilitate a proper localization and delivery of new agents to this region. The NAc is a fascinating and potentially rich target for stereotactic neurosurgical intervention, and analysis of existing information regarding all aspects of this structure should help potentiate therapeutic advances and reduce complications from future studies of neurosurgical intervention in this region for a variety of disorders.

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Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex

Cited by 125 publications

References 38 publications

Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation

Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation

Effects of Prenatal Stress on Conduction Airway Morphology

The Nucleus Accumbens: A Comprehensive Review

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