Stress-Induced Changes in the Functional Activity of the Neuroendocrine System: The Modulatory Activity of Derinat

Fomicheva, E. E.; Filatenkova, T A; Shanin, S. N.; Rybakina, E. G.

doi:10.1007/s11055-010-9270-z

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…It can be assumed that this effect is associated with the influence of the combined effect of TLR9 + TLR4 agonists on the migration and proliferation of AP cells (Root-Bernstein 2021). Fomicheva et al it was shown that the preventive administration of Derinat ® at a dose of 10 mg/kg stimulates an increase in the level of testosterone and corticosterone in animals, against the background of cold stress, immobilization and the introduction of LPS, led to an increase and subsequent maintenance of a high level of these hormones for 24 h after the stressful impacts (Fomicheva et al, 2010). Maintaining high levels of testosterone and corticosterone is an effective mechanism for increasing the body's resistance to stress (Sapolsky et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Derinat® has an immunomodulatory and anti-inflammatory effect on the model of acute lung injury in male SD rats

et al. 2022

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To simulate acute lung injury (ALI) in SD male rats they we administered intratracheally with lipopolysaccharide (LPS) followed by hyperventilation of the lungs (HVL), which lead to functional changes in the respiratory system and an increase in the blood serum concentration of inflammatory cytokines. LPS + HVL after 4 h lead to pronounced histological signs of lung damage. We have studied the effectiveness of Derinat® when administered intramuscularly at dose of 7.5 mg/kg for 8 days in the ALI model. Derinat® administration lead to an increase in the concentration of most of the studied cytokines in a day. In the ALI model the administration of Derinat® returned the concentration of cytokines to its original values already 48 h after LPS + HVL, and also normalized the parameters of pulmonary respiration in comparison with animals without treatment. By the eighth day after LPS + HVL, respiratory parameters and cytokine levels, as well as biochemical and hematological parameters did not differ between groups, while histological signs of residual effects of lung damage were found in all animals, and were more pronounced in Derinat® group, which may indicate stimulation of the local immune response. Thus, the administration of Derinat® stimulates the immune response, has a pronounced protective effect against cytokinemia and respiratory failure caused by ALI, has immunomodulatory effect, and also stimulates a local immune response in lung tissues. Thus, Derinat® is a promising treatment for ALI.

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Section: Discussionmentioning

confidence: 99%

Derinat® has an immunomodulatory and anti-inflammatory effect on the model of acute lung injury in male SD rats

et al. 2022

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“…Since an increase in GDNF, NGF, or brain-derived neurotrophic factor (BDNF) has been reported for these treatments as well, the Лечение черепно-мозговой травмы Brain trauma treatment with Derinat 2021, Vol. 23,6 2021, Т. 23, № 6 administration of Derinat can also be an alternative therapy.…”

Section: Discussionmentioning

confidence: 99%

“…These Лечение черепно-мозговой травмы Brain trauma treatment with Derinat 2021, Vol. 23,6 2021, Т. 23, № 6 changes initiate dynamic and evolving processes that result in inflammatory, neurochemical and metabolic alterations [9,63,84].…”

Section: Introductionmentioning

confidence: 99%

“…Derinat is isolated from the soft roes of Acipenser gueldenstaedtii (Russian sturgeon), the sodium salt of highly purified native double-stranded DNA (molecular weight; 270-500 kDa), being used in Russia and several other countries in clinic for different pathological conditions [23,34,51]. It has been shown that this drug after applying weight-drop model of rat's TBI can normalize splenocyte cytotoxicity and proliferative activity on the 14 th day after TBI.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of Derinat, a nucleotide-based drug, on experimental traumatic brain injury, and its cellular mechanisms

et al. 2021

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Traumatic brain injury is the most common cause of death and disability in young people including sport athletes and soldiers, people under 45 years of age in the industrialized countries, representing a growing health problem in developing countries, as well as in aging communities. Treatment of the latter is a serious challenge for modern medicine. This type of injury leads to many kinds of disorders and, quite often, to disability. These issue require development of new methods for brain trauma treatment. The new approach to brain trauma treatment was studied in murine experiments. In particular, sodium salt of deoxyribonucleic acid (DNA) was used. This preparation is a drug known as a mixture of peptides with immunomodulatory effect which is widely used for different kinds of therapy. Derinat, a sodium salt of DNA, isolated from the caviar of Russian sturgeon, is a proven immunomodulator for treatment of diseases associatd with reactive oxygen species (ROS), including brain ischemia-reperfusion (IR) injury. Here we show that treatment with Derinat exert neuroprotective, anti-oxidative, and anti-inflammatory effects in experimental model of traumatic brain injury (TBI) in rats. Intraperitoneal injection of Derinat several times over 3 days after TBI showed less pronounced damage of the injured brain area. Immunohistochemical study showed that the Derinat-induced morphological changes of microglia in cerebral cortex and hippocampus 7 days after TBI. TBI-induced accumulation of 8-oxoguanine (8-oxoG), the marker of oxidative damage, was significantly attenuated by Derinat administration, both on 7th and 14th day after TBI. To investigate cellular mechanism of anti-inflammatory effects, the primary cultures of murine microglia supplied with ATP (50 M and 1 mM), as a substance released at injured site, were used to mimic the in vitro inflammatory response. Derinate treatment caused an increase of glial levels of mRNAs encoding neurotrophic factor (GDNF) and nerve growth factor (NGF) in the presence of ATP, whereas tissue plasminogen activator (tPA) mRNA was inhibited by ATP with or without Derinat. Interleukin-6 (IL-6) mRNA expression was not affected by ATP but was increased by Derinat. Both mRNA and protein levels of ATP-induced TNFα production were significantly inhibited by Derinat. These results partially contribute to understanding mechanisms of immunomodulatory effects of DNA preparations in traumatic brain injury.

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“…DA is an important part in central nervous system; previous studies have demonstrated that DA's function disorder is associated with schizophrenia and Parkinson disease or some other mental abnormality [ 27 ]. In the chronic cold and humid stress condition, not only the pituitary-adrenal cortex system but also the sympathetic adrenomedullary system is involved; thus, contents of catecholamine are elevated in blood; besides, DA is precursor of NE [ 28 ]. In conclusion, long-term exposure to cold and humid stress is most likely to activate hypothalamic-pituitary-ovarian axis and sympathetic adrenomedullary system at a chronic excitatory state and increase the levels of monoamine neurotransmitters such as DA, NE, and EP which inhibit hypothalamus-pituitary-genital axis, while generating endocrine and immune function disorder [ 29 , 30 ], eventually exceeding body's autoregulation range, and it leads to ovarian failure.…”

Section: Discussionmentioning

confidence: 99%

Research on Establishment of Abnormal Phlegmatic Syndrome with Premature Ovarian Failure Rat Model and Effects of Balgham Munziq Treatment

Yuemaier

Tuerhong

Keremu

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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This study aimed to establish and explore the biological basis of abnormal phlegmatic syndrome with premature ovarian failure (POF) model in rats based on the Uighur medicine (UM) in the first place and investigate the effects of unique herbal medicine, Balgham Munziq (BMq). Mature female Wistar rats were fed with spinach and coriander in cold and humid condition for approximately 20 weeks until abnormal phlegmatic syndrome (APS) model was established. When APS model was confirmed by Uighur medical experts, APS with POF disease rats were subdivided into APS with POF disease model group and APS with POF disease treated with BMq group; the rest of them were subdivided into APS model group and APS treated with BMq group. The results show that biological characteristics of animals in the course of modeling period were in accordance with clinical features of abnormal phlegmatic syndrome (APS) in Uighur medicine. Herbal medicine BMq not only reverted reproductive hormone levels disorders but also improved the function of hypothalamic-pituitary-ovarian axis and regulated secretion of monoamine neurotransmitters. APS is most likely to cause pathological changes of hypothalamic-pituitary-ovarian axis and lead to the occurrence of POF and BMq is effective in the treatment of APS with POF disease.

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Stress-Induced Changes in the Functional Activity of the Neuroendocrine System: The Modulatory Activity of Derinat

Cited by 6 publications

References 8 publications

Derinat® has an immunomodulatory and anti-inflammatory effect on the model of acute lung injury in male SD rats

Derinat® has an immunomodulatory and anti-inflammatory effect on the model of acute lung injury in male SD rats

Protective effects of Derinat, a nucleotide-based drug, on experimental traumatic brain injury, and its cellular mechanisms

Research on Establishment of Abnormal Phlegmatic Syndrome with Premature Ovarian Failure Rat Model and Effects of Balgham Munziq Treatment

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