2008
DOI: 10.1016/s2173-5115(09)70246-5
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Stress oxidativo na lesão pulmonar neonatal

Abstract: Artigo de Revisão Revision Article Resumo O stress oxidativo é um dos factores de risco para o desenvolvimento de displasia broncopulmonar no recém-nascido de pré-termo. Este apresenta deficiente defesa antioxidante. Por outro lado, o stress oxidativo também tem papel no crescimento e desenvolvimento celular. A relação entre stress oxidativo e crescimento celular necessita de ser melhor conhecida antes da introdução de terapêuticas antioxidantes. Várias terapêuticas antioxidantes têm sido tentadas, até ao mome… Show more

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Cited by 2 publications
(3 citation statements)
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“…Abdominal movements are part of the neonatal respiratory mechanics and mainly reflect the biomechanical disadvantages of the rib cage, such as increased compliance, more horizontal ribs and diaphragm, reduced diaphragmatic zone of apposition and immature abdominal and intercostal muscles 1 . In our study, abdominal participation was greater the lower the gestational age and birth weight, corroborating the idea of the immaturity of the respiratory system 1 and strengthening the hypothesis of the occurrence of changes in respiratory mechanics and of thoracoabdominal asynchrony 15 .…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Abdominal movements are part of the neonatal respiratory mechanics and mainly reflect the biomechanical disadvantages of the rib cage, such as increased compliance, more horizontal ribs and diaphragm, reduced diaphragmatic zone of apposition and immature abdominal and intercostal muscles 1 . In our study, abdominal participation was greater the lower the gestational age and birth weight, corroborating the idea of the immaturity of the respiratory system 1 and strengthening the hypothesis of the occurrence of changes in respiratory mechanics and of thoracoabdominal asynchrony 15 .…”
Section: Discussionsupporting
confidence: 89%
“…Studies show that PTNBs who use oxygen for more than 10 days have respiratory depression, pulmonary vasodilation, systemic arterial vasoconstriction and pulmonary fibrosis [15][16][17] . One hypothesis to explain our findings is related to pulmonary fibrosis, which would decrease rib cage compliance, increasing abdominal participation in breathing and corroborating the findings of Rocha 15 and Pereira 16 . This also explains the fact that the length of hospital stay has a negative relationship with thoracic participation.…”
Section: Discussionmentioning
confidence: 99%
“…Relacionado ao uso desta terapia, a residente aprendeu que assim como no adulto, diversas são as formas de administração e isso depende do fluxo desejado podendo ser via cateter nasal, cânula nasal, capacete (halo ou campânula), tenda, incubadora ou ainda via máscara nasal (CARVALHO et al, 2005;SARMENTO, 2007). Além disso aprendeu que ao fazer uso desta terapia em neonatologia e pediatria, a mesma deve ser realizada com a mistura dos gases, oxigênio e ar comprimido, através de um misturador de gases, para desta forma reduzir as complicações causadas pelo oxigênio que é altamente tóxico quando utilizado de forma indiscriminada e errada, estando associado a diversas complicações pulmonares (SILVA, 2013;ROCHA, 2008;NAUMBURG et al, 2002NAUMBURG et al, , p. 1328NAUMBURG et al, -1333.…”
Section: Discussionunclassified