Stress reduction treatment of severe recurrent genital herpes virus

VanderPlate, Cal; Kerrick, Georgia

doi:10.1007/bf01000753

Cited by 28 publications

(10 citation statements)

References 8 publications

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“…A prototypical example of this is the stress‐induced reactivation of herpes viruses . Chronic stress increases recurrence of herpes simplex virus types 1 and 2, whereas stress‐reduction strategies reduce reactivation . Similarly, psychosocial stress increases the incidence of varicella zoster virus; again, psychological intervention can enhance immunity to this virus …”

Section: Implications Of Stress Pathway Activation On Skin Homeostasismentioning

confidence: 99%

The impact of psychosocial stress on healthy skin

2015

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Dermatologists are only too aware of the significant role psychosocial stress plays in the exacerbation of skin disease; indeed, it is often the first precipitant patients mention when they attend outpatient clinics. Of late, research has focused on understanding the 'brain-skin' axis, a complex interplay between the nervous and immune systems and the skin. In particular, there is an evolving body of literature exploring the underlying pathophysiological mechanisms by which psychosocial stress influences skin homeostasis. This article provides a broad overview of the literature, emphasizing the importance of individual stress perception and summarizing the varied roles of the major cutaneous stress-response pathways. Both central [the hypothalamic-pituitary-adrenal (HPA) axis and the locus ceruleus-norepinephrine (LC-NE) sympathetic adrenomedullary system] and peripheral (the intracutaneous HPA axis and the release of mediators from peripheral sensory and autonomic nerves) pathways are discussed. Moreover, how activation of these pathways affects the skin's immune system, barrier function, wound healing and susceptibility to infection is reviewed. Although this field of research is rapidly expanding, several important questions remain unanswered, including: what is the precise role of mast cells in the cutaneous stress response?; what is the role of regulatory T-cells?; can therapeutic intervention be harnessed to prevent the stress-induced exacerbation of skin disease? It is anticipated that an improved understanding of the underlying mechanisms through which psychosocial stress affects the homeostasis of healthy skin will not only increase knowledge of the brain-skin axis but will also improve the holistic management of stress-responsive cutaneous disease.

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Section: Implications Of Stress Pathway Activation On Skin Homeostasismentioning

confidence: 99%

The impact of psychosocial stress on healthy skin

2015

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“…Human studies show that persistent, but not single or acute, stressors are associated with the frequency of recurrences, which is in agreement with findings that chronic, but not acute stress, correlates with the development of experimental viral infections in normal volunteers (46,93,94). Furthermore, psychosocial interventions have been shown to decrease the frequency of recurrences of herpes simplex infections (95).…”

Section: Stress and Skin Diseasesmentioning

confidence: 99%

Psychoneuroimmunology

Tausk¹,

Elenkov²,

Moynihan³

2008

Dermatol Ther

110

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Psychoneuroimmunology (PNI) is a discipline that has evolved in the last 40 years to study the relationship between immunity, the endocrine system, and the central and peripheral nervous systems. In this manner, neurotransmitters, hormones, and neuropeptides have been found to regulate immune cells, and these in turn are capable of communicating with nervous tissue through the secretion of a wide variety of cytokines. Of critical importance is the effect of products of the CNS and nerves on the maintenance of the delicate balance between cell-mediated (Th1) and humoral (Th2) immune responses. A good example of how this concept operates in vivo becomes evident when analyzing the effects of stressors. Chronic stress affects significantly the function of the immune system as well as modifies the evolution of a variety of skin diseases, as psychosocial interventions have proved to be effective in their therapy.

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“…15,16 Stress has also been linked to faster progression to acquired immunodeficiency syndrome 17 and to increased frequency of herpes simplex recurrences, 18 which decrease or resolve with stress-reduction therapies. 19 Such behavioral techniques are believed to have an immunomodulatory effect, as exemplified by relaxation training, which significantly enhances natural killer cell activity, 20 which in turn is associated with antitumor effects. 21 Psychosocial interventions have been reported to improve the evolution of inflammatory and skin diseases, [22][23][24] as well as to enhance the survival of patients with cancer.…”

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confidence: 99%