Stress-related health depreciation: Using allostatic load to predict self-rated health

Barry, Luke; O’Neill, Stephen; Heaney, Liam G.; O’Neill, Ciarán

doi:10.1016/j.socscimed.2021.114170

Cited by 8 publications

(4 citation statements)

References 65 publications

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“…To examine to what extent each component of the overall health measure contributed to the increased risk of poor health outcomes, we also analysed the relationship between each of its indicators of deteriorating health reserves and mortality and self-rated health. Our analyses revealed that each indicator of deteriorating health reserves was related to self-rated health, consistent with results of previous studies [ 27 , 39 , 40 ]. However, the overall health measure had the greater effect on the self-rated health estimate than each indicator of deteriorating health reserves.…”

Section: Discussionsupporting

confidence: 91%

Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort

et al. 2023

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Background Defining and measuring Health presents a challenge, partly due to its conceptual pluralism. To measure Health as an ability to adapt and self-manage, we developed an approach within the theoretical framework of resources and reserves over the life course, recently proposed in the literature. We aimed to (i) use the conceptual framework developed to identify indicators of deteriorating health reserves, (ii) construct an overall health measure from these indicators, (iii) evaluate the association between the overall health measure and subsequent health outcomes and (iv) assess the robustness of our method. Methods We used data from 7,043 individuals born in 1958 in Great Britain included in the National Child Development Study. An overall health measure was constructed via the sum of three selected indicators of deteriorating health reserves in mid-life: chronic widespread pain (CWP), Clinical Interview Schedule - revised (CIS-r), and allostatic load (AL). A three-category variable was defined: impaired/medium/optimal overall health. We explored criterion validity by modelling the relationships between the overall health measure, or each reserve taken separately at 44–45 years, and self-rated health at 46 years and mortality up to 58 years, corresponding to 14 years of follow up, using Cox and logistic regressions respectively. We performed comparative analyses to assess the robustness of the method. Results Having an impaired overall health measure was significantly associated with all-cause premature mortality (HRimpaired = 2.74 [1.86; 4.05]) and an increased risk of later fair/poor/very poor self-rated health (ORimpaired = 7.50 [6.29; 8.95]). The overall health measure had a greater effect on the self-rated health estimates than each indicator of deteriorating health reserves considered separately (ORAL medium = 1.82 [1.59; 2.09]; ORAL high = 2.74 [2.37; 3.16]; ORCIS-r = 5.20 [4.45; 6.08]; ORCWP = 2.85 [2.53; 3.21]). CIS-r and allostatic load were also associated with premature mortality contrary to chronic widespread pain (HRAL medium1.82 [1.27; 2.61]; HRAL high = 3.10 [2.19; 4.40]; HRCIS-r = 1.77 [1.22; 2.56]; HRCWP = 1.32 [0.98; 1.76]). The multiple comparative analyses conducted allowed us to assess the robustness of our method within this cohort. Conclusions We proposed a method for measuring Health in mid-life in line with the concept of Health as the ability to adapt and self-manage and the concept of health reserves. This method may be applied and further developed within the field of social and positive epidemiology.

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Section: Discussionsupporting

confidence: 91%

Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort

et al. 2023

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“…To examine to what extent each component of the global health score contributed to the increased risk of poor health outcomes, we also analysed the relationship between each of its indicators of deteriorating health reserves and mortality and self-rated health. Our analyses revealed that each indicator of deteriorating health reserves was related to self-rated health, consistent with results of previous studies (31,42,43). However, the global health score had the greater effect on the self-rated health estimate than each indicator of deteriorating health reserves.…”

Section: Discussionsupporting

confidence: 90%

Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort

Joannès

Collineaux

Guernec

et al. 2022

Preprint

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Background Defining and measuring “Health” presents a challenge, partly due to its conceptual pluralism. To measure “Health” as an ability to adapt and self-manage, we developed an approach within the theoretical framework of resources and reserves over the life course, recently proposed in the literature. We aimed to (i) use the conceptual framework developed to identify indicators of deteriorating health reserves, (ii) construct a global health score from these indicators, (iii) evaluate the association between the global health score and subsequent health outcomes and (iv) assess the robustness of our method. Methods We used data from 7,043 individuals born in 1958 in Great Britain included in the National Child Development Study. A global health score was constructed via the sum of three selected indicators of deteriorating health reserves in mid-life: chronic widespread pain (CWP), clinical interview schedule (CIS-r), and allostatic load (AL). A three-category variable was defined: impaired/medium/optimal health. We explored criterion validity by modelling the relationships between the global health score, or each reserve taken separately, and mortality and self-rated health using Cox and logistic regressions respectively. We performed sensitivity analyses to assess the robustness of the method. Results Having an impaired global health score was significantly associated with all-cause premature mortality (HRimpaired= 2.74 [1.86; 4.05]) and an increased risk of later fair/poor/very poor self-rated health (ORimpaired = 7.50 [6.29; 8.95]). The global health score had a greater effect on the self-rated health estimates than each indicator of deteriorating health reserves considered separately (ORAL medium=1.82 [1.59; 2.09]; ORAL high=2.74 [2.37; 3.16]; ORCIS-r= 5.20 [4.45; 6.08]; ORCWP= 2.85 [2.53; 3.21]). Clinical interview schedule and allostatic load were also associated with premature mortality contrary to chronic widespread pain (HRAL medium1.82 [1.27; 2.61]; HRAL high= 3.10 [2.19; 4.40]; HRCIS-r=1.77 [1.22; 2.56]; HRCWP=1.32 [0.98; 1.76]). The multiple sensitivity analyses conducted allowed us to confirm the robustness of our method. Conclusions We proposed a method for measuring a global health score in line with a definition of health based on the concept of reserve. This method may be applied and further developed within the field of social and positive epidemiology.

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“…However, very few models are developed based on mortality risk due to the lack of large‐scale longitudinal data 23,80 . Regarding the subjective assessment of perceived health, the performance of the ageing biomarker may be subject to recall bias introduced by raters 317,318 …”

Section: Challengesmentioning

confidence: 99%

Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities

Chen

Wang

Zhang

et al. 2023

MedComm – Future Medicine

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Given the unprecedented phenomenon of population ageing, studies have increasing captured the heterogeneity within the ageing process. In this context, the concept of "biological age" has been introduced as an integrated measure reflecting the individualized ageing pace. Identifying reliable and robust biomarkers of age is critical for the accurate risk stratification of individuals and exploration into antiageing interventions. Numerous potential biomarkers of ageing have been proposed, spanning from molecular changes and imaging characteristics to clinical phenotypes. In this review, we will start off with a discussion of the development of ageing biomarkers, then we will provide a comprehensive summary of currently identified ageing biomarkers in humans, discuss the rationale behind each biomarker and highlight their accuracy and clinical value with a contemporary perspective. Additionally, we MedComm -Future Medicine.

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Stress-related health depreciation: Using allostatic load to predict self-rated health

Cited by 8 publications

References 65 publications

Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort

Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort

Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort

Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities

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