Stress-sensitive tissue regeneration in viscoelastic biomaterials subjected to modulated tensile strain

Belfiore, Laurence A.; Floren, Michael; Paulino, Alexandre Tadeu; Belfiore, Carol J.

doi:10.1016/j.bpc.2011.04.008

Cited by 5 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This resistance can be considered to be the main factor that influences the performance of the membrane as a whole; in directing the differentiation of stem cells that are mechanosensitive to the surrounding environment, the release of growth factors or other adhered nanoparticles with a pharmacokinetic potential increase. A delayed speed of degradation occurs because mechanical deformation occurs in layers and is proportional to the rates of nutrient consumption by the cells [ 18 , 20 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Mechanical interest has increased in response to the unbalanced gap in the need for matrices with consistency and functional integrity, allowing for proper handling, suturing without breaking, and the enhancement of biological space for the continued release of cells and GFs over time [ 8 , 20 ]. Even though blood composition is specific and individual, PRF-based matrices are reproducible systems with a distribution independent of the characteristics of the donor, making it possible to perform a clot analysis under appropriate conditions for study [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation

et al. 2022

View full text Add to dashboard Cite

Predictable outcomes intended by the application of PRF (platelet-rich fibrin) derivative membranes have created a lack of consideration for their consistency and functional integrity. This study aimed to compare the mechanical properties through tensile strength and analyze the structural organization among the membranes produced by L-PRF (leukocyte platelet-rich fibrin), A-PRF (advanced platelet-rich fibrin), and A-PRF+ (advanced platelet-rich fibrin plus) (original protocols) that varied in centrifugation speed and time. L-PRF (n = 12), A-PRF (n = 19), and A-PRF+ (n = 13) membranes were submitted to a traction test, evaluating the maximum and average traction. For maximum traction, 0.0020, 0.0022, and 0.0010 N·mm−2 were obtained for A-PRF, A-PRF+, and L-PRF, respectively; regarding the average resistance to traction, 0.0012, 0.0015, and 0.006 N·mm−2 were obtained, respectively (A-PRF+ > A-PRF > L-PRF). For all groups studied, significant results were found. In the surface morphology observations through SEM, the L-PRF matrix showed a highly compact surface with thick fibers present within interfibrous areas with the apparent destruction of red blood cells and leukocytes. The A-PRF protocol showed a dense matrix composed of thin and elongated fibers that seemed to follow a preferential and orientated direction in which the platelets were well-adhered. Porosity was also evident with a large diameter of the interfibrous spaces whereas A-PRF+ was the most porous platelet concentrate with the greatest fiber abundance and cell preservation. Thus, this study concluded that A-PRF+ produced membranes with significant and higher maximum traction results, indicating a better viscoelastic strength when stretched by two opposing forces.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The study on the viscoelastic properties of the TMV-derived nanostructured materials is still lacking despite the availability of the elastic property of the TMV and TMV-based nanotube composites [7]. The viscoelasticity of micro/nanobioarchitecture significantly affects the tissue regeneration [21] and repair [22], cell growth and aging [23], and human stem cell differentiation [24] as well as the appropriate biological functions of the membranes within a specific nanoenvironment [25]; in particular, the viscoelasticity of some viruses plays key roles in the capsid expansion for releasing nucleic acid and modifying protein cages for vaccine delivery purposes [26]. Specifically, for TMV superlattice, its nanotube structure makes it a perfect biotemplate for synthesizing nanolattices that have been confirmed to possess extraordinary mechanical features with ultralow density [27,28].…”

Section: Introductionmentioning

confidence: 99%

Transient viscoelasticity study of tobacco mosaic virus/Ba2+ superlattice

Wang

et al. 2014

Nanoscale Res Lett

View full text Add to dashboard Cite

Recently, we reported a new method to synthesize the rod-like tobacco mosaic virus (TMV) superlattice. To explore its potentials in nanolattice templating and tissue scaffolding, this work focused the viscoelasticity of the superlattice with a novel transient method via atomic force microscopy (AFM). For measuring viscoelasticity, in contrast to previous methods that assessed the oscillating response, the method proposed in this work enabled us to determine the transient response (creep or relaxation) of micro/nanobiomaterials. The mathematical model and numerical process were elaborated to extract the viscoelastic properties from the indentation data. The adhesion between the AFM tip and the sample was included in the indentation model. Through the functional equation method, the elastic solution for the indentation model was extended to the viscoelastic solution so that the time dependent force vs. displacement relation could be attained. To simplify the solving of the differential equation, a standard solid model was modified to obtain the elastic and viscoelastic components of the sample. The viscoelastic responses with different mechanical stimuli and the dynamic properties were also investigated.

show abstract

Mechanical Behaviour and Finite Element Analysis of Biomaterials: A Review

Sharma

Kukshal

2021

Lecture Notes in Mechanical Engineering

View full text Add to dashboard Cite

Stress-sensitive tissue regeneration in viscoelastic biomaterials subjected to modulated tensile strain

Cited by 5 publications

References 29 publications

Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation

Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation

Transient viscoelasticity study of tobacco mosaic virus/Ba2+ superlattice

Mechanical Behaviour and Finite Element Analysis of Biomaterials: A Review

Contact Info

Product

Resources

About