Stress that Endures: Influence of Adverse Childhood Experiences on Daily Life Stress and Physical Health in Adulthood.

Mosley-Johnson, Elise; Campbell, Jennifer A.; Garacci, Emma; Walker, Rebekah J.; Egede, Leonard E.

doi:10.1016/j.jad.2021.02.018

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…Lastly, because childhood adversity often cascades across the lifecourse (Hostinar, Lachman, et al, 2015; Mosley-Johnson et al, 2021; Raposa et al, 2014), sensitivity analyses also examined whether the association between childhood stress and inflammation may reflect current ongoing stress, particularly in adulthood. To test this hypothesis, we examined whether controlling versus not controlling for adulthood stress emerged as a signfiicant moderator and performed a subgroup analysis that synthesized effect sizes that adjusted for stress levels in adulthood.…”

Section: Methodsmentioning

confidence: 99%

Psychological stress during childhood and adolescence and its association with inflammation across the lifespan: A critical review and meta-analysis.

Chiang¹,

Lam²,

Chen³

et al. 2022

Psychological Bulletin

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Psychological stress during childhood and adolescence increases risk of health problems across the lifecourse, and inflammation is implicated as an underlying mechanism. To evaluate the viability of this hypothesis, we used meta-analysis to quantify the association between childhood/adolescent stress and inflammation over the lifecourse. Furthermore, we addressed three unresolved conceptual questions: (a) Does the strength of this association change over the lifecourse? (b) Are different types of childhood/adolescent stressors differentially associated with inflammation? (c) And which components of the inflammatory response are involved? A systematic search identified 187 articles reporting 922 associations. Meta-analyses were conducted using a three-level multilevel approach and controlled for study quality, conversion confidence, and whether effect sizes were unadjusted or adjusted (n = 662, 72%). Results indicated a small but reliable overall adjusted association (rfalse^ = .04). The magnitude of the association strengthened across the lifecourse—effect sizes were smallest in studies that measured inflammation in childhood (rfalse^ = .02) and became progressively larger in studies of adolescence (rfalse^ = .04) and adulthood (rfalse^ = .05), suggesting the impact of early stress strengthens with time. By contrast, effect sizes did not vary by adversity type (socioeconomic disadvantage, maltreatment, other interpersonal stressors, and cumulative exposure across stressors), or component of inflammation (circulating biomarkers of low-grade inflammation vs. cytokine responses to microbial stimuli). Implications and future directions are discussed.

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Section: Methodsmentioning

confidence: 99%

Psychological stress during childhood and adolescence and its association with inflammation across the lifespan: A critical review and meta-analysis.

Chiang¹,

Lam²,

Chen³

et al. 2022

Psychological Bulletin

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“…Our secondary aim, informed by the organizationaldevelopment perspective (Sroufe et al, 2005), was to examine whether a history of adverse childhood experiences (ACEs) would interact with exposure to pandemic-related events to predict mental health, well-being, and substance use outcomes. ACE exposure is robustly associated with higher daily stressors and more types of daily stressors in adulthood (Mosley-Johnson et al, 2021) as well as increased risk for mental and physical health problems (Hughes et al, 2017). In addition, ACE exposure affects mental and physical health through associations with increased stressors and compromised coping (Karatekin, 2018;Mc Elroy & Hevey, 2014).…”

Section: Empirical Articlementioning

confidence: 99%

A Prospective Study of Mental Health, Well-Being, and Substance Use During the Initial COVID-19 Pandemic Surge

Haydon

Salvatore

2021

Clinical Psychological Science

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The COVID-19 pandemic has dramatically altered everyday life worldwide, and some individuals may be at increased risk for pandemic-related distress. In a U.S. community sample ( N = 236, 64% female; 78% White; mean age = 30.3 years) assessed before COVID-19 and during the initial surge, we examined, prospectively, whether pandemic disruptions and a history of adverse childhood experiences (ACEs) were associated with changes in depressive symptoms, stress, sleep, relationship satisfaction, and substance use over time and with concurrent anxiety and peritraumatic distress. Negative pandemic-related events were associated with significantly higher depressive symptoms and stress and lower satisfaction over time as well as higher concurrent anxiety and peritraumatic distress. ACEs were associated with more negative pandemic-related events, which, in turn, associated with higher peripandemic depressive symptoms, stress, anxiety, and peritraumatic distress. Findings underscore that COVID-19 disruptions are associated with greater distress and that childhood trauma is a key axis of differential risk.

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“…Our finding that childhood trauma was unrelated to self-reported stress as assessed in daily life contradicts previous research in healthy adults, which has shown programming effects of early life stress. For instance, a large-scale population-based study has found that individuals with adverse childhood experiences had a higher risk of experiencing everyday life stress in adulthood ( 8 ). Notably, this study employed a retrospective measure of daily stress.…”

Section: Discussionmentioning

confidence: 99%

“…One aetiopathogenetic factor that has emerged as particularly relevant in this research is psychosocial stress and alterations in stress-responsive bodily systems ( 5 – 7 ). Concretely, it has been found that extreme forms of stress experienced early in life, such as childhood trauma, are followed by increased levels of everyday life stress in adulthood ( 8 ) and can permanently compromise stress-responsive bodily systems, such as the autonomic nervous system and the hypothalamic-pituitary-adrenal axis ( 9 ). These findings are in line with models of developmental programming and plasticity, such as the adaptive calibration model ( 10 ), as well as the allostatic load model ( 11 ), which describe neurobiological alterations in response to environmental demands.…”

Section: Introductionmentioning

confidence: 99%

Does childhood trauma impact daily psychobiological stress in somatic symptom disorder? An ambulatory assessment study

et al. 2022

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ObjectivesSomatic symptom disorder is characterized by excessive thoughts, feelings, and behaviors dedicated to bodily symptoms, which are often medically unexplained. Although 13% of the population are affected by this disorder, its aetiopathogenesis is not fully understood. Research in medically unexplained conditions (e.g., fibromyalgia) points to increased psychosocial stress and alterations in stress-responsive bodily systems as a potential contributing factor. This pattern has often been hypothesized to originate from early life stress, such as childhood trauma. The aim of this study was to examine, for the first time, whether individuals with somatic symptom disorder exhibit elevated levels of self-reported daily stress and alterations in the autonomic nervous system and hypothalamic-pituitary-adrenal axis, both in comparison to healthy controls and individuals with depressive disorders, and whether reports of childhood trauma influence these alterations.MethodsA total of N = 78 individuals were recruited into this study. Of these, n = 27 had a somatic symptom disorder, n = 23 were healthy controls, and n = 28 had a depressive disorder. All individuals underwent a 14-day measurement period at home, with five assessments of self-reported stress, salivary alpha-amylase, and cortisol per day. Childhood trauma was assessed by the Childhood Trauma Questionnaire.ResultsIndividuals with somatic symptom disorder exhibited higher daily stress levels (p = 0.063) as well as a less pronounced alpha-amylase awakening response (p = 0.050), compared to healthy controls (statistical trends). Moreover, they were characterized by significantly attenuated diurnal cortisol concentrations (p < 0.001). A nearly identical pattern was observed in individuals with depression. In individuals with somatic symptom disorder and depressive disorders, childhood trauma was, by trend, associated with a more pronounced alpha-amylase awakening response (b = −0.27, p = 0.077).ConclusionsThis study provides preliminary evidence for elevated daily stress and blunted sympathetic and hypothalamic-pituitary-adrenal axis activity in individuals with somatic symptom disorder and depressive disorders. Further studies will help to uncover the conditions under which these dysregulations develop into medically unexplained vs. depressive symptoms.

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Stress that Endures: Influence of Adverse Childhood Experiences on Daily Life Stress and Physical Health in Adulthood.

Cited by 15 publications

References 36 publications

Psychological stress during childhood and adolescence and its association with inflammation across the lifespan: A critical review and meta-analysis.

Psychological stress during childhood and adolescence and its association with inflammation across the lifespan: A critical review and meta-analysis.

A Prospective Study of Mental Health, Well-Being, and Substance Use During the Initial COVID-19 Pandemic Surge

Does childhood trauma impact daily psychobiological stress in somatic symptom disorder? An ambulatory assessment study

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