Stressful psychosocial factors and symptoms of gastroesophageal reflux disease: a population-based study in Norway

Jansson, Catarina; Wallander, Mari‐Ann; Johansson, Saga; Johnsen, Roar; Hveem, Kristian

doi:10.3109/00365520903401967

Cited by 45 publications

(23 citation statements)

References 32 publications

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“…Several studies have documented significant variations in morbidity of internalizing disorders and stress exposure among different ethnic groups . Significant relationships between psychosocial factors and the development of a broad array of gastrointestinal disorders had been reported . A recent animal study demonstrated that acute stress can increase esophageal permeability, which shed light on the patho‐physiological mechanism of GERD .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and determinants of gastroesophageal reflux symptoms in adolescents

Chen

Wang

Lin

et al. 2014

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Prevalence and determinants of gastroesophageal reflux symptoms in adolescents

Chen

Wang

Lin

et al. 2014

J of Gastro and Hepatol

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“…Laboratory stress has been found to increase the perception of intraluminal acid stimuli and induced stress, anxiety, anger in GERD patients rather than normal control. [25] Stressful psychosocial factors can induce GERD, [26] and stress may also induce bipolar disorder in patients genetically prone to developing bipolar disorder. [27], [28] Psychological stress also may activate inflammatory responses in the brain.…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal Reflux Disease and Risk for Bipolar Disorder: A Nationwide Population-Based Study

Lin

Liu

et al. 2014

PLoS ONE

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BackgroundStudies have shown that chronic inflammation may play a vital role in the pathophysiology of both gastroesophageal reflux disease (GERD) and bipolar disorder. Among patients with GERD, the risk of bipolar disorder has not been well characterized.ObjectiveWe explored the relationship between GERD and the subsequent development of bipolar disorder, and examined the risk factors for bipolar disorder in patients with GERD.MethodsWe identified patients who were diagnosed with GERD in the Taiwan National Health Insurance Research Database. A comparison cohort without GERD was matched according to age, sex, and comorbidities. The occurrence of bipolar disorder was evaluated in both cohorts based on diagnosis and the prescription of medications.ResultsThe GERD cohort consisted of 21,674 patients, and the comparison cohort consisted of 21,674 matched control patients without GERD. The incidence of bipolar disorder (incidence rate ratio [IRR] 2.29, 95% confidence interval [CI] 1.58–3.36, P<.001) was higher among GERD patients than among comparison cohort. Multivariate, matched regression models showed that the female sex (hazard ratio [HR] 1.78, 95% CI 1.76–2.74, P = .008), being younger than 60 years old (HR 2.35, 95% CI 1.33–4.16, P = .003), and alcohol use disorder (HR 4.89, 95% CI 3.06–7.84, P = .004) were independent risk factors for the development of bipolar disorder among GERD patients.ConclusionsGERD may increase the risk of developing bipolar disorder. Based on our data, we suggest that attention should be focused on female patients younger than 60 years, and patients with alcohol use disorder, following a GERD diagnosis.

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“…Clinical research indicates that the severity of GORD symptoms varies substantially across patients, and evidence suggests that psychological factors are likely to contribute to this variability. For instance, it has been shown that individuals experiencing psychological distress, such as anxiety or depression, are more likely to report oesophageal symptoms and to be diagnosed with GORD (Jansson et al., ; Shapiro et al., ; Kessing et al., ). Another study showed that catastrophic thinking is associated with more intense pain among patients with painful gastrointestinal problems, including GORD (Drossman et al., ).…”

Section: Introductionmentioning

confidence: 99%

Does catastrophic thinking enhance oesophageal pain sensitivity? An experimental investigation

Martel

Olesen

Jørgensen

et al. 2016

European Journal of Pain

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Taken together, findings from the present study suggest that catastrophic thinking exerts an influence on oesophageal pain sensitivity, but not necessarily on the magnitude of acid-induced oesophageal sensitization. WHAT DOES THIS STUDY ADD?: Catastrophizing is associated with heightened pain sensitivity in the oesophagus. This was substantiated by assessing responses to noxious stimulation of the oesophagus using an experimental paradigm mimicking features and symptoms experienced by patients with gastro-oesophageal reflux disease (GORD).

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Stressful psychosocial factors and symptoms of gastroesophageal reflux disease: a population-based study in Norway

Abstract: This population-based study reveals a link between stressful psychosocial factors, including job strain, and GERD symptoms.

Cited by 45 publications

References 32 publications

Prevalence and determinants of gastroesophageal reflux symptoms in adolescents

Prevalence and determinants of gastroesophageal reflux symptoms in adolescents

Gastroesophageal Reflux Disease and Risk for Bipolar Disorder: A Nationwide Population-Based Study

Does catastrophic thinking enhance oesophageal pain sensitivity? An experimental investigation

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