Background and Objectives: To study the Depression and Anxiety in diagnosed esophageal reflux disease cases and to compare it with the age and sex matched controls Methods: Study conducted in the gastro-enterology unit of Sri Aurobindo Medical College and PostGraduate Institute, Indore. After taking an informed consent in their local language (Hindi), we recruited 100 patients with symptoms and endoscopic evidence of GERD along with 100 age and sex matched controls. Patients diagnosed to have GERD on the basis of either frequent complaints of heartburn and/or acid regurgitation for the last 3 months and the presence of endoscopic evidence of GERD. Following instruments were administered: A semi-structured socio-demographic pro-forma, Mini International Neuropsychiatric interview, Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety and Diagnostic and Statistical Manual of Mental Disorders-5. Results: The present study revealed that significantly higher number of GERD patients suffered from depression (46%) and anxiety (31%) as compared to their matched controls. Also, both HAM-D and HAM-A scores showed higher numbers of GERD patients to be having 'severe' or 'very severe' forms of psychological morbidity than the controls. Patients with GERD used tobacco, in smoking or chewing form, in significantly higher numbers than the controls, while alcohol users were underrepresented in both groups. Conclusion: In summary, among the 100 GERD cases 56 were found to have psychiatric morbidity in form of either anxiety or depression.