2014
DOI: 10.1371/journal.pone.0107694
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Gastroesophageal Reflux Disease and Risk for Bipolar Disorder: A Nationwide Population-Based Study

Abstract: BackgroundStudies have shown that chronic inflammation may play a vital role in the pathophysiology of both gastroesophageal reflux disease (GERD) and bipolar disorder. Among patients with GERD, the risk of bipolar disorder has not been well characterized.ObjectiveWe explored the relationship between GERD and the subsequent development of bipolar disorder, and examined the risk factors for bipolar disorder in patients with GERD.MethodsWe identified patients who were diagnosed with GERD in the Taiwan National H… Show more

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Cited by 14 publications
(16 citation statements)
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“…Lin et al found that GERD may increase the risk of developing bipolar disorder [8]. However, according to our study, GERD and bipolar disorder are unrelated.…”
Section: Discussionsupporting
confidence: 56%
See 3 more Smart Citations
“…Lin et al found that GERD may increase the risk of developing bipolar disorder [8]. However, according to our study, GERD and bipolar disorder are unrelated.…”
Section: Discussionsupporting
confidence: 56%
“…First, the development of psychiatric disorders may be the result of an inflammatory process caused by GERD. In patients with GERD, the esophageal mucosa produces various cytokines and chemokines, including IL-6, IL-8, IL-1β, TNF-α, PAF, and ROS [7,8]. Increases in inflammatory cytokines and chemokines can affect CNS functions and up-regulate CNS cytokine production [11,23].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The stratification by age groups showed significant associations of BWD with depression in young, middle-aged and old individuals in dependent of BMI. Stratification by BMI categories resulted in statistically significant positive associations of body weight dissatisfaction and depression in underweight, normal weight, overweight and obese individuals [21]. Unfortunately, in the present study specific questions regarding weight satisfaction, GERD and depression were not explored, but WHOQoL-BREF included domain questions regarding body image (domain-2), the responses to which showed significantly higher scores among the controls compared to GERD patients (t = 3.44, df = 198; p = 0.0007).…”
Section: Gerd: Body Weight Dissatisfaction and Depressionmentioning
confidence: 94%