Stressors and pain sensitivity in CFW mice. Role of opioid peptides

Konecka, Anna Maria; Sroczyńska, Irmina

doi:10.3109/13813459009113984

Cited by 23 publications

(15 citation statements)

References 25 publications

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“…This is supported by human imaging studies revealing that social disconnection engages brain regions including the dorsal anterior cingulate cortex and anterior insula cortex, which also process the affective component of physical pain . This dual role of DRN dopamine neurons also points toward a potential mechanism through which acute isolation reduces pain perception . It is also interesting to note that inflammatory pain is suppressed by activation of AgRP neurons, suggesting a general reduction of chronic pain perception by strong motivational drive states .…”

Section: Proposed Attributes Of Components Within a Social Homeostatimentioning

confidence: 76%

“…In rats, a 24‐h social isolation increased preference for ethanol and opioid intake, which was reversed with social housing . Reduced pain sensitivity has also been reported, with male mice and juvenile rats exhibiting higher thermal and mechanical pain thresholds following 2–7 days of social isolation . The prominent role of dopamine and opioid signaling in mediating the effects of drugs of abuse and analgesia makes them strong contenders for underlying these adaptations.…”

Section: Homeostatic Response To Social Deficit: a Self‐protective Comentioning

confidence: 99%

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Neural mechanisms of social homeostasis

Matthews

Tye

2019

Annals of the New York Academy of Sciences

154

101

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Social connections are vital to survival throughout the animal kingdom and are dynamic across the life span. There are debilitating consequences of social isolation and loneliness, and social support is increasingly a primary consideration in health care, disease prevention, and recovery. Considering social connection as an “innate need,” it is hypothesized that evolutionarily conserved neural systems underlie the maintenance of social connections: alerting the individual to their absence and coordinating effector mechanisms to restore social contact. This is reminiscent of a homeostatic system designed to maintain social connection. Here, we explore the identity of neural systems regulating “social homeostasis.” We review findings from rodent studies evaluating the rapid response to social deficit (in the form of acute social isolation) and propose that parallel, overlapping circuits are engaged to adapt to the vulnerabilities of isolation and restore social connection. By considering the neural systems regulating other homeostatic needs, such as energy and fluid balance, we discuss the potential attributes of social homeostatic circuitry. We reason that uncovering the identity of these circuits/mechanisms will facilitate our understanding of how loneliness perpetuates long‐term disease states, which we speculate may result from sustained recruitment of social homeostatic circuits.

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Section: Proposed Attributes Of Components Within a Social Homeostatimentioning

confidence: 76%

Section: Homeostatic Response To Social Deficit: a Self‐protective Comentioning

confidence: 99%

Neural mechanisms of social homeostasis

Matthews

Tye

2019

Annals of the New York Academy of Sciences

154

101

View full text Add to dashboard Cite

show abstract

“…Social isolation also modulates pain perception. As for mice, withdrawal latencies in the hot-plate test increased under conditions of social isolation (18). By contrast, several animal studies have reported that some stressors, such as vibration (19) and forced swimming (20), elicit hyperalgesia instead of analgesia.…”

Section: Introductionmentioning

confidence: 99%

Partner Loss in Monogamous Rodents: Modulation of Pain and Emotional Behavior in Male Prairie Voles

et al. 2018

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“…A similar phenomena is also found among nonhuman animals. Isolation, a phenomenon that is associated with social pain, produces reduced sensitivity to physical pain in rat pups (Kehoe & Blass, 1986a, 1986bNaranjo & Fuentes, 1985;Spear et al, 1985), mice (Konecka & Sroczynska, 1990), cows (Rushen et al, 1999), and chicks (Sufka & Hughes, 1990;Sufka & Weed, 1994).…”

Section: Social Pain Causes Physical Numbnessmentioning

confidence: 99%