Striatal glutamate and the conversion to psychosis: a prospective 1H-MRS imaging study

Fuente‐Sandoval, Camilo de la; León-Ortíz, Pablo; Azcárraga, Mariana; Favila, Rafael; Stephano, Sylvana; Graff‐Guerrero, Ariel

doi:10.1017/s1461145712000314

Cited by 78 publications

(46 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of antipsychotic medication on MRS measures remains unknown. Some off medication studies reported higher levels of glutamatergic metabolites (de la Fuente-Sandoval et al, 2011, 2013a, 2013bKegeles et al, 2012;Kraguljac et al, 2013), whereas others reported reduced or no difference (Goto et al, 2012;Wood et al, 2008). However, higher levels of glutamatergic metabolites do not appear to be specific to the off medication state since several studies reported higher glutamatergic metabolites in medicated patients (Aoyama et al, 2011;Bustillo et al, 2014;Chang et al, 2007;Theberge et al, 2003) and in treatment resistant patients taking medication (Demjaha et al, 2014;Egerton et al, 2012;Mouchlianitis et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Wijtenburg

Wright

Korenic

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

The neurobiology of schizophrenia (SZ) may be altered in older versus younger adults with SZ, as less frequent episodes of symptom exacerbation and increased sensitivity to medications are observed in older age. The goal of this study was to examine the effect of age and diagnosis on glutamate and cerebral blood flow (rCBF) in adults with SZ and healthy controls. Young and older adults with SZ and healthy controls were recruited to participate in this study. Participants completed a neuropsychological battery and neuroimaging that included optimized magnetic resonance spectroscopy to measure anterior cingulate (AC) glutamate (Glu) and glutamine (Gln) and arterial spin labeling evaluation for rCBF. Regression analyses revealed significant effects of age with Glu, Gln, Gln/Glu, and AC white matter (WM) rCBF. Glu and WM rCBF decreased linearly with age while Gln and Gln/Glu increased linearly with age. Glu was lower in adults with SZ compared with healthy controls and in older adults versus younger adults but there was no interaction. Glu and WM rCBF were correlated with the UCSD Performance-Based Skills Assessment (UPSA) and processing speed, and the correlations were stronger in the SZ group. In the largest sample to date, lower Glu and elevated Gln/Glu levels were observed in adults with SZ and in older subjects. Contrary to expectation, these results do not show evidence of accelerated Glu aging in the anterior cingulate region in SZ compared with healthy controls.

show abstract

Section: Discussionmentioning

confidence: 99%

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Wijtenburg

Wright

Korenic

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The fact that our FEP group did not show such association raises the need for future studies to explore the moment along the illness course at which both measures become linked, as this could be informative in terms of both neurocognitive and psychosocial functioning decrease. Additionally, future crosssectional and longitudinal studies in larger samples are needed to address the heterogeneity of functional outcomes in the UHR population (Addington et al, 2011), prediction of conversion to full-blown psychosis (Cannon et al, 2008;Ruhrmann et al, 2010;de la Fuente-Sandoval et al, 2013), and the effect of psychotropic medication on this population.…”

Section: Discussionmentioning

confidence: 99%

Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis

Solís-Vivanco

Mondragón‐Maya

León-Ortíz³

et al. 2014

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

“…Independent work has reported that both UHR and first episode subjects have higher levels of glutamate in the caudate nucleus than controls [80], and that UHR subjects that subsequently developed psychosis had higher striatal glutamate levels than UHR subjects who did not become psychotic [98]. A study that examined a medial prefrontal region failed to find altered glutamate or glutamine in UHR or first episode subjects, but did find reductions in chronic patients [99].…”

Section: Studies In Subjects At Uhr For Psychosismentioning

confidence: 99%

Translating the MAM model of psychosis to humans

Modinos

Allen

Grace

et al. 2015

Trends in Neurosciences

148

122

View full text Add to dashboard Cite

Elevated dopamine function and alterations in the medial temporal lobe structure and function (MTL) are two of the most robust findings in schizophrenia, but how interactions between these abnormalities underlie the onset of psychosis is unclear. Although several preclinical models of psychosis have been proposed, the methylazoxymethanol acetate (MAM) rodent model provides a mechanistic account linking these two clinical observations. The model proposes that psychosis develops as a result of a perturbation of MTL function, leading to elevated striatal dopamine dysfunction. We review a number of recent neuroimaging studies that examine components of the putative model in people with an ultra high risk (UHR) of psychosis. Whilst data from these studies are broadly consistent with the MAM model, that the potential for comparing various kinds of neurobiological data across animal and human studies imposes some limitations on what can be inferred from these data. Going forward, longitudinal studies are needed to explicitly test the model’s predictions in UHR populations.

show abstract

Striatal glutamate and the conversion to psychosis: a prospective 1H-MRS imaging study

Cited by 78 publications

References 21 publications

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis

Translating the MAM model of psychosis to humans

Contact Info

Product

Resources

About