Stripping Voltammetric Determination of Analgesics in Their Pharmaceuticals Using Nano-Riboflavin-Modified Glassy Carbon Electrode

Abstract

Cyclic voltammetric behaviors of three analgesics, acetaminophen (AAP), acetylsalicylic acid (ASA), and dipyrone (DP), were studied using nano-riboflavin-modified glassy carbon electrode. One well-defined oxidation peak each for AAP and ASA and three oxidation peaks for DP were observed. The influence of pH, scan rate, and concentration reveals irreversible diffusion controlled reaction. The SEM analysis confirmed good accumulation of the drugs on the electrode surface. Calibration was made under the maximum peak current conditions. The concentration range studied for the determination of drugs was 0.02 to 0.4 μg mL−1for AAP and ASA and 0.025 to 0.4 μg mL−1for DP. The lower limit of detection observed for AAP, ASA, and DP was 0.016, 0.007 μg mL−1, and 0.013 μg mL−1, respectively. The suitability of the method for the determination of these analgesics in pharmaceutical preparations and urine samples was also ascertained.

Poly(thionine)-carbon nanotube modified carbon film electrodes and application to the simultaneous determination of acetaminophen and dipyrone

“…Higher sensitivities were obtained in [12,14], but with narrower linear ranges. Detection limits were similar to those in [12] and much lower than in [9]; although they were higher than those in [13,42,43] ( [13,43] using stripping voltammetric techniques), in these cases, the upper linear range limits were only 2.6 μM [13,43] and 16 μM [42].…”

A mechanistic study on the electrocatalysis of the Pu(iv)/Pu(iii) redox reaction at a platinum electrode modified with single-walled carbon nanotubes (SWCNTs) and polyaniline (PANI)

“…19,20 In practical cases, the slope values lying between 0.20-0.60 and 0.75-1.10 are considered pure diffusion and pure adsorption controlled processes, respectively. 21,22 The slope lying between 0.60-0.75 is considered a mixed adsorption-diffusion controlled process. 21,22 The plots of log?Ip?…”

“…21,22 The slope lying between 0.60-0.75 is considered a mixed adsorption-diffusion controlled process. 21,22 The plots of log?Ip? versus log (n) for both the cathodic and anodic peaks yield straight lines of gradients 0.33 (R 2 = 0.994) and 0.35 (R 2 = 0.987), respectively.…”

Effects of 99mTc on the electrochemical properties of thiamazole in vitro

“…Cyclic voltammetry is now used as a technique for studying the redox potential of different types of drugs. By using this technique, it is also possible to establish an irreversible controlled diffusion-reaction by monitoring the effects of pH, scan rate and concentration [12].…”