This chapter explores the intersection of artificial intelligence (AI) and personalized learning, highlighting the potential to revolutionize accessibility and inclusivity in special education. Drawing from psychological and pedagogical research, the chapter delves into the nuanced impact of AI-driven tools' capacity to transform instruction, enrich educational experiences, and bolster access to various disciplines. Challenges, bias, and potential exclusionary barriers emerge, necessitating a critical examination of how AI's potential transformative impact reshapes the landscape of inclusion and accessibility in the educational sphere. By identifying emerging challenges and proposing pathways for advancement, the chapter underscores the importance of ensuring that AI technologies advance rather than hinder inclusive and accessible educational practices, with an ultimate aim to establish a more accessible learning environment tailored to the diverse needs of students with disabilities.