Stroke knowledge among emergency centre visitors: A cross-sectional multicenter survey

Chakroun-Walha, Olfa; Samet, Amal; Abdallah, Marwa Ben; Benmansour, Sana; Issaoui, Fadhila; Rebai, Manel; Messaoud, Karama Ben; Benali, Cyrine; Mokni, Wassel; Nasri, Abdennour; Rejeb, Imen; Rekik, Noureddine

doi:10.1016/j.afjem.2020.10.012

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Furthermore, the stroke knowledge of patients with hypertension is an important stroke-prevention indicator of healthcare service quality. The Stroke Knowledge Test (SKT) has been translated into various languages and adapted for use in different cultural contexts 3 , 17 . Strokes are known to be an important health problem in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

Translation and validation of the Chinese version of the stroke knowledge test for the hypertension patient

Wang,

Chen,

Lin

2023

Sci Rep

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The measurement of hypertensive patients’ stroke knowledge is an important stroke prevention indicator of health care service quality. The aim of this study was to develop a Chinese version of the Stroke Knowledge Test and examine its psychometric properties, reliability, and validity for hypertensive patients. A sample of 200 hypertensive patients completed the Chinese version of the Stroke Knowledge Test, and 30 of the participants were retested after 2 weeks. The final Chinese version of the Stroke Knowledge Test included 20 items with acceptable content validity (I-CVI = 0.88 ~ 1.00, S-CVI/Ave = 0.97). These items showed satisfactory internal reliability consistency (Kuder Richardson-20 = 0.62) and test–retest reliability was 0.77. The 40% of the difficulty index was in the acceptable range, and 25% was in the difficult range, as well as the 90% items overall values for discrimination were ranged from 0.2 to > 0.4. Known-group validity testing was performed based on the education level, and the result exhibited significant difference (F = 21.21, p < 0.001). The Chinese version of the Stroke Knowledge Test demonstrated acceptable psychometric properties, thus providing a new tool for the future care of hypertensive patients in Taiwan. It also could be as a reference for healthcare providers to educate hypertensive patients on stroke prevention.

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Section: Introductionmentioning

confidence: 99%

Translation and validation of the Chinese version of the stroke knowledge test for the hypertension patient

Wang,

Chen,

Lin

2023

Sci Rep

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“…Globally, stroke is one of the leading causes of death, with the number of people affected being higher in low- and middle-income countries than in high-income countries [ 3 ]. According to the American Health Association’s 2020 Update, 1 in 19 deaths in the United States is attributable to stroke; the World Health Organization calls stroke the epidemic of the 21st century [ 4 , 5 , 6 ]. The risk factors for cerebral ischemia are similar to those for coronary and other vascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Advances in Antibody-Based Therapeutics for Cerebral Ischemia

et al. 2022

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Cerebral ischemia is an acute disorder characterized by an abrupt reduction in blood flow that results in immediate deprivation of both glucose and oxygen. The main types of cerebral ischemia are ischemic and hemorrhagic stroke. When a stroke occurs, several signaling pathways are activated, comprising necrosis, apoptosis, and autophagy as well as glial activation and white matter injury, which leads to neuronal cell death. Current treatments for strokes include challenging mechanical thrombectomy or tissue plasminogen activator, which increase the danger of cerebral bleeding, brain edema, and cerebral damage, limiting their usage in clinical settings. Monoclonal antibody therapy has proven to be effective and safe in the treatment of a variety of neurological disorders. In contrast, the evidence for stroke therapy is minimal. Recently, Clone MTS510 antibody targeting toll-like receptor-4 (TLR4) protein, ASC06-IgG1 antibody targeting acid sensing ion channel-1a (ASIC1a) protein, Anti-GluN1 antibodies targeting N-methyl-D-aspartate (NMDA) receptor associated calcium influx, GSK249320 antibody targeting myelin-associated glycoprotein (MAG), anti-High Mobility Group Box-1 antibody targeting high mobility group box-1 (HMGB1) are currently under clinical trials for cerebral ischemia treatment. In this article, we review the current antibody-based pharmaceuticals for neurological diseases, the use of antibody drugs in stroke, strategies to improve the efficacy of antibody therapeutics in cerebral ischemia, and the recent advancement of antibody drugs in clinical practice. Overall, we highlight the need of enhancing blood–brain barrier (BBB) penetration for the improvement of antibody-based therapeutics in the brain, which could greatly enhance the antibody medications for cerebral ischemia in clinical practice.

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Biotechnology-based therapeutics for management of cerebral stroke

Patel

Wairkar

2021

European Journal of Pharmacology

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Stroke knowledge among emergency centre visitors: A cross-sectional multicenter survey

Cited by 4 publications

References 30 publications

Translation and validation of the Chinese version of the stroke knowledge test for the hypertension patient

Translation and validation of the Chinese version of the stroke knowledge test for the hypertension patient

Advances in Antibody-Based Therapeutics for Cerebral Ischemia

Biotechnology-based therapeutics for management of cerebral stroke

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