Stromal collapse in acute atrophy of lymphoid organs

Oliveira‐Filho, Jamary; Andrade, Zilton A.

doi:10.1016/s0940-2993(11)80025-4

Cited by 1 publication

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“…Findings observed in two animals that apparently survived the critical period of massive parasitized-cell destruction are suggestive that reconstitution of splenic structure may be quite r a p i d a n d c o m p l e t e . T h a t c a p a c i t y f o r regeneration shown by the spleen is in keeping with observations made in other lymphoid tissues 8 . …”

Section: Discussionsupporting

confidence: 87%

Kinetics of Trypanosoma cruzi destruction in the mouse spleen

Cordeiro¹,

Dahia²,

Andrade

1997

Rev. Soc. Bras. Med. Trop.

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Massive destruction of parasitized splenic macrophages was histologically observed at the height of a virulent infection caused by Trypanosoma cruzi (Y strain) in the mouse. This was coincident with a sudden drop in parasitemic curve. Most of the animals died at this point, probably due to the liberation of toxic products, such as TNF, following the massive destruction of parasitized cells. However, parasitized-cell destruction indicated the transition from susceptibility to resistance. Although it has been extensively studied in vitro, this study contributes with the morphological counterpart observed in vivo by optical and electron microscopy. When infected animals were specifically treated during early infection transition to chronic phase was immediately observed without splenic parasitism. Animals that apparently recovered from massive cell-destruction in the spleen showed evidences of a rapid restoration of splenic architecture.

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Section: Discussionsupporting

confidence: 87%