Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients – a multicenter collaborative study

Fonseca, Felipe Paiva; Coletta, Ricardo D.; Azevedo, Marina Barbosa; Ribeiro, Ana Carolina Prado; Soubhia, Ana Maria Pires; Miyahara, Glauco Issamu; Carlos, Román; Farthing, Paula M.; Hunter, Keith D.; Speight, Paul M.; Vargas, Pablo Agustı́n; Almeida, Oslei Paes de; Lopes, Márcio Ajudarte; Santos‐Silva, Alan Roger

doi:10.1016/j.oooo.2014.07.012

Cited by 18 publications

(22 citation statements)

References 34 publications

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“…These proteins are related to cell cycle, local invasion, lymphatic growth, cell proliferation, and activation of carcinogenic products. In several other studies, no significant difference was observed between TSCC in young and older patients regarding molecular markers of cell cycle (p53, p21, pRb, MDM2), cell proliferation (Ki67), angiogenic index (vWF), and lymphatic vessel density (podoplanin), as well as the presence of stromal myofibroblasts . Mesquita et al observed the immunostaining for galectin‐3 and galectin‐7 in 65.6% and 96.8% of the cases of OSCC in young patients, respectively, with no significant association with clinical parameters.…”

Section: Genetic Alterationsmentioning

confidence: 93%

Molecular basis of oral squamous cell carcinoma in young patients: Is it any different from older patients?

Costa

Brennan

Gomez

et al. 2018

J Oral Pathology Medicine

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Oral squamous cell carcinoma (OSCC) is the commonest subtype of oral cancer, mainly affecting older patients. It used to be a rare disease among individuals younger than 40 years, but recently increased incidences in this age group are being reported worldwide. The pathogenesis of OSCC affecting young patients remains controversial, and the well-known etiological factors for oral cancer, tobacco, and alcohol use are believed to play a minor role in the carcinogenesis of the neoplasm, suggesting that the etiology and the molecular basis of OSCC may differ between younger and older patients. Although several molecular markers and chromosomal abnormalities have been demonstrated to differ between both groups, most of the studies have failed to find significant differences. Moreover, divergent results have also been obtained regarding the presence of high-risk human papillomavirus infection in OSCC of young patients. Given these contradictory results and the limited methodological approaches of the majority of the studies, the exact difference between both age groups remains to be fully established. In this review, we evaluate the available data to establish the current evidence that might support the hypothesis that the molecular basis of OSCC in young patients (especially those under 40 years) differ from the older patients.

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Section: Genetic Alterationsmentioning

confidence: 93%

Molecular basis of oral squamous cell carcinoma in young patients: Is it any different from older patients?

Costa

Brennan

Gomez

et al. 2018

J Oral Pathology Medicine

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“…Semiquantitative analysis of SMA was jointly carried out by two observers, and each case was classified as negative (0) (0%‐5% of stromal positivity) or positive (1) (>56% of stromal positivity) …”

Section: Methodsmentioning

confidence: 99%

Different patterns of expression of cell cycle control and local invasion‐related proteins in oral squamous cell carcinoma affecting young patients

Galvis

Santos‐Silva

Jardim

et al. 2017

J Oral Pathology Medicine

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Funding information Brazilian Coordination of Higher EducationObjectives: Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide, and the clinical and behavioral characteristics of tumors in this group are controversial, and the literature shows divergent results. Results: Clinicopathological features and survival rates were similar in both groups.

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“…9,[11][12][13][14][15] Oral squamous cell carcinoma occurring amongst the younger individuals have an increased aggressiveness and poor clinical prognosis when compared to those affecting the elderly subjects. 6,7,12,16,17 The prognosis of the condition is determined by the prognostic factors that would in turn determine the biological aggressiveness of the condition amongst the subjects. The various prognostic factors include regional lymph node metastasis, location of tumor and TNM classification.…”

Section: Introductionmentioning

confidence: 99%

Clinical findings and risk factors associated with oral cancer: a prospective study

Gupta¹,

Singh²,

Bedi³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral cancer is associated with high morbidity and mortality and therefore it represents a grave health problem worldwide. However there is scarcity of the studies in the literature regarding the prognostic factors amongst the subjects. The aim of the present study is to determine the various risk factors and the most commonly affected sites by the oral squamous cell carcinoma amongst subjects of different age groups. Methods: The present prospective comparative study was conducted at the Department of Radiotherapy at Guru Gobind Singh Medical College and Hospital during a period of three months i.e. from April 2016 to June 2016. Patients were evaluated every week for a period of approximately 2 weeks. Examination of the oral cavity was done using probe and mouth mirror by trained personnel. TNM classification was used to classify tumour. Patient’s habits like alcohol and tobacco intake were also recorded. Complete demographic information was obtained from all the patients. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software. Results: The study included a total of 60 subjects. There were 11 females in the study and 49 males in the study. There were 18.3% (n=11) subjects having cancer of tongue. There were 23.3% (n=14) subjects having cancer of buccal mucosa. Alveolar ridge carcinoma was seen in 8.3% (n=5) subjects. There were 22 patients (30%) having stage III carcinoma. Majority of the subjects i.e. 70% (n= 38) were at stage IV A according to TNM classification. Conclusions: From the above study we can conclude that there is lack of awareness amongst the people about oral cancer. They mostly present during advanced stage of the disease. Most of the subjects are males, showing there predisposition towards harmful habits.

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Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients – a multicenter collaborative study

Abstract: There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individuals.

Cited by 18 publications

References 34 publications

Molecular basis of oral squamous cell carcinoma in young patients: Is it any different from older patients?

Molecular basis of oral squamous cell carcinoma in young patients: Is it any different from older patients?

Different patterns of expression of cell cycle control and local invasion‐related proteins in oral squamous cell carcinoma affecting young patients

Clinical findings and risk factors associated with oral cancer: a prospective study

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