Strong and Bioactive Tri-Calcium Phosphate Scaffolds with Tube-Like Macropores

Zheng, Wei; Liu, Gang; Chen, Yan; Xiao, Yin; Miao, Xigeng

doi:10.4028/www.scientific.net/jbbte.19.65

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…However, it is necessary to match the rate of resorbtion with that of the expected bone tissue regeneration. When the solubility of a calcium phosphate is higher than the rate of tissue regeneration, it will only be limited use in bone cavity and defect filling [14]. figures (8, 9, and 10) respectively.…”

Section: Results and Discussion: Sem Analysismentioning

confidence: 99%

Preparation of Calcium Phosphate Via Precipitation Technique

Hussain¹,

Alwan²

2015

ETJ

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Recently, there has been an increasing attention on the preparation of calcium phosphates CaP for the development, understanding and manufacturing of biomaterials. In this study, precipitation process was performed to prepare calcium phosphates powders by varying the Ca/P molar ratio as (1.54, 1.67 and 1.8). Calcium acetate was added to disodium hydrogen phosphate, the precipitate was left overnight and dried at 100 o C and then the powder was treated at 900 o C for 1 hour. The powder sample was evaluated using such as scanning electron microscope (SEM), X-ray diffraction (XRD), atomic force molecules (AFM) and Fourier Transform Infrared (FTIR). It can be concluded, it is possible to synthesis hydroxyapatite (HA) and biphasic calcium phosphate (BCP) powders with nano particle.

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Section: Results and Discussion: Sem Analysismentioning

confidence: 99%

Preparation of Calcium Phosphate Via Precipitation Technique

Hussain¹,

Alwan²

2015

ETJ

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“…The increase in porosity is beneficial for biological property enhancement, as a larger fraction of interconnected pores favour cell adhesion and penetration into the scaffold leading to better bone tissue regeneration [59]. The incorporation of Cpt in the HA structure led to the decrease in the bulk density to 2.72 g cm −3 , which was assigned to the phase transformation of HA to βTCP and incorporation of Cpt in the structure [60,61]. A study conducted by Kolken et al showed that the biomaterial with lower relative density allows for maximal bone ingrowth into the scaffold variant [62].…”

Section: Cpt-ha Porous Scaffoldsmentioning

confidence: 99%

Porous clinoptilolite—nano biphasic calcium phosphate scaffolds loaded with human dental pulp stem cells for load bearing orthopedic applications

et al. 2019

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Clinoptilolite (Cpt)-nanohydroxyapatite (HA) (Cpt-HA) scaffolds were fabricated as a potential material for loadbearing orthopaedic applications. Cpt-HA materials were successfully synthesized by using microwave assisted reflux method followed by the fabrication of three-dimensional (3D) porous scaffold via thermal decomposition process using polyethylene glycol (PEG)/ polyvinyl alcohol (PVA) as porogens. The scaffold materials were characterized using x-ray diffraction, Fourier transform Infra-red, Scanning electron microscopy and Energy dispersive spectroscopy techniques. Incorporation of Cpt in HA scaffold significantly increased the compressive strength and surface hardness while scaffolds retained an interconnected porous structure with 64% porosity. Human dental pulp stem cells (DPSCs) were isolated from the third molar and used as pluripotent-like cell model to evaluate the biological properties of Cpt-HA scaffolds. Highest cellular attachment and proliferation were observed for DPSCs seeded on 2.0 g Cpt-HA scaffolds compare to pure HA. Similarly, significantly higher ALP activity of cells was observed on Cpt-HA scaffolds compared to pure HA. The enhanced proliferation and osteogenic response of the DPSCs cultured on Cpt-HA scaffolds suggest that the fabricated scaffolds can be used in bone tissue engineering. In this work, we have successfully shown that the interconnected porous Cpt-HA scaffolds have superior mechanical biological properties compared to pure HA scaffold.

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“…The brittleness and bearing load of CaP scaffolds with highly interconnected pores limit the application of this compound in bone restoration [28,29]. The compressive strength of porous scaffolds with CaP as the matrix is only 3 MPa [30], and scaffolds with bioactive borosilicate glass can lead to dense struts and a maximum compressive strength of approximately 10 MPa given an overall porosity of approximately 70% [31,32]. This study employed an approach that combines a multilayer PLA composite with CPC matrix; the composite displayed highcompressive strength of over 10 MPa before immersion.…”

Section: Strength and Modulus Of Pla/cpc Composite Tubesmentioning

confidence: 99%

A comparison of the heat treatment duration and the multilayered effects on the poly(lactic) acid braid reinforced calcium phosphate cements used as bone tissue engineering scaffold

Chen

Shih

et al. 2016

Journal of Industrial Textiles

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Composites comprising a braided poly(lactic) acid (PLA) filament and calcium phosphate bone cement (CPC) were inferred to maintain space and to pack porous fillers into restorative sites. Composites of alkalized multilayer-PLA braids and CPC (PLA/CPC) were divided into various groups according to a series of heat-treatment periods that lasted for 60, 90, 120, 150, and 180 min at 160℃; subsequently, these composites were characterized. Strength decays of samples were also compared after 24 h immersion in Hanks’s physiological solution. Results showed that the PLA/CPC specimens were toughened after treatment at 160℃ for 120 min. Furthermore, the moduli of PLA/CPC groups increased significantly when the heating time was more than 150 min; this effect was generated by the cold crystallization within the PLA filaments. The reduced stress in the composites after immersion was attributed to the fibers that protruded from the scaffold surface and to hydrolysis. The mechanical test results for the PLA/CPC composites indicated that the toughening effect was strengthened significantly under prolonged heat treatment, especially when the heating time was longer than 150 min. The cold crystallization degree of PLA increased, thereby enhancing the strength and toughness of a specimen before immersion. Thus, PLA/CPC composites can be used to simulate potential bone functions as well as to maintain three-dimensional spaces and pack porous fillers into restorative sites conveniently.

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Strong and Bioactive Tri-Calcium Phosphate Scaffolds with Tube-Like Macropores

Cited by 11 publications

References 17 publications

Preparation of Calcium Phosphate Via Precipitation Technique

Preparation of Calcium Phosphate Via Precipitation Technique

Porous clinoptilolite—nano biphasic calcium phosphate scaffolds loaded with human dental pulp stem cells for load bearing orthopedic applications

A comparison of the heat treatment duration and the multilayered effects on the poly(lactic) acid braid reinforced calcium phosphate cements used as bone tissue engineering scaffold

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