Strong and fast rising pressure waves emitted by plasmonic vapor nanobubbles

Lombard, Julien; Lam, Julien; Detcheverry, François; Biben, Thierry; Mérabia, Samy

doi:10.1103/physrevresearch.3.023231

Cited by 17 publications

(11 citation statements)

References 70 publications

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“…An alternative inactivation mechanism related to local plasma ignition through fs-pulsed NIR radiation in the presence of resonant Au nanoantennas is a shockwave-mediated inactivation of microbes. Recombination of ions in the plasma formed at an electromagnetic hot-spot associated with a resonantly excited noble metal nanostructure releases energy, and the associated rapid local increase in temperature and pressure triggers the emission of shockwaves and the formation of cavitation vapor bubbles. − Indeed, images of an aqueous suspension of metal NRs in a cuvette irradiated with a focused beam of an 800 nm fs-pulsed laser confirmed laser-induced bubble formation under the typical experimental conditions of pathogen inactivation through plasmon-enhanced fs-pulsed NIR radiation (Figure ). If a shockwave emitted from irradiated NPs hits a pathogen, for instance, a virus particle, forces at the interface between virus and ambient medium generate mechanical stress that could cause damage to the virus structure or impair viral surface functionalities.…”

Section: Plasmon-enhanced Shockwave Formation For Pan-microbial Patho...mentioning

confidence: 95%

Plasmonic Enhancement Strategies for Light-Driven Microbe Inactivation

Reinhard

2022

J. Phys. Chem. C

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Light can be an effective antimicrobial. UV-C light, in particular, is now commonly used to sterilize inanimate surfaces, water, and even air. Highly energetic light can, however, also lead to unwanted photodamage and be hazardous. Consequently, conventional light-mediated microbe inactivation is not suitable for all applications. Plasmonic nanostructures can enhance electromagnetic fields in the visible range of the electromagnetic spectrum and show unique light-induced responses that can drive strong antimicrobial effects even for wavelengths that without plasmonic enhancement have little to no antimicrobial impact. Plasmonic nanostructures offer thus a potential strategy to expand the antimicrobial effect of light to wavelength and intensity ranges in which light-associated collateral damages are lower. This Perspective examines selected plasmon-enhanced antimicrobial strategies, elucidates the underlying physicochemical mechanisms, and discusses applications.

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Section: Plasmon-enhanced Shockwave Formation For Pan-microbial Patho...mentioning

confidence: 95%

Plasmonic Enhancement Strategies for Light-Driven Microbe Inactivation

Reinhard

2022

J. Phys. Chem. C

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“…VNB-formation takes place when the heated NPs evaporate the liquid in their immediate vicinity. The VNB will increase in size until the NPs’ thermal energy is depleted, at which point the VNB collapses again [ 13 , 16 , 17 , 18 ]. Rapid expansion and collapse of VNBs induce mechanical stress on the nearby cell membrane, resulting in pore formation [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology to Efficiently Optimize Intracellular Delivery by Photoporation

Goemaere

Punj

Harizaj

et al. 2023

IJMS

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Photoporation is an up-and-coming technology for the gentle and efficient transfection of cells. Inherent to the application of photoporation is the optimization of several process parameters, such as laser fluence and sensitizing particle concentration, which is typically done one factor at a time (OFAT). However, this approach is tedious and runs the risk of missing a global optimum. Therefore, in this study, we explored whether response surface methodology (RSM) would allow for more efficient optimization of the photoporation procedure. As a case study, FITC-dextran molecules of 500 kDa were delivered to RAW264.7 mouse macrophage-like cells, making use of polydopamine nanoparticles (PDNPs) as photoporation sensitizers. Parameters that were varied to obtain an optimal delivery yield were PDNP size, PDNP concentration and laser fluence. Two established RSM designs were compared: the central composite design and the Box-Behnken design. Model fitting was followed by statistical assessment, validation, and response surface analysis. Both designs successfully identified a delivery yield optimum five- to eight-fold more efficiently than when using OFAT methodology while revealing a strong dependence on PDNP size within the design space. In conclusion, RSM proves to be a valuable approach to efficiently optimize photoporation conditions for a particular cell type.

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“…In medical therapy and diagnostics, the safety of a procedure is a constant concern. The question as to what is the primary cause of laser-induced mechanical damage in the case of a single cell is still not completely resolved: is it the rapidly growing laser-induced cavitation bubble or the shock wave released as the bubble expands, the latter with two possible contributing reasons: the large peak pressure and the large spatial and temporal pressure gradients, owing to the fast rise time [9] , [10] . The answer depends largely on the individual circumstances of each application [11] , [12] .…”

Section: Introductionmentioning

confidence: 99%

“…The importance of the stress rise time was recognized also by Doukas et al [14] when they showed that the cellular damage by stress waves correlates better with the stress rise time than by its peak value while Douki et al [15] observed lower cell killing for 20 ns rise time pulses than for 10 ns rise times. In a study by Lombard et al [9] critical pressure rise time was found to be 5 MPa/ns, at least for lower power energy input as is pursued in medical use of lasers today.…”

Section: Introductionmentioning

confidence: 99%