2016
DOI: 10.1038/ijo.2016.4
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Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention

Abstract: A PD with ad libitum intake had a significant and persistent effect on liver fat and differed significantly from a conventional LFD at 6 months. This difference may be due to food quality, for example, a higher content of mono- and polyunsaturated fatty acids in the PD. Changes in liver fat did not associate with alterations in insulin sensitivity.

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Cited by 51 publications
(100 citation statements)
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“…An increased fat storage capacity in AT due to this adaptive response may decrease the spillover of lipids from subcutaneous fat and prevent ectopic fat deposition and metabolic dysfunction . In line with this, we recently reported that a PD can reduce liver fat after both short‐ and long‐term intervention in postmenopausal women with obesity .…”
Section: Discussionmentioning
confidence: 83%
“…An increased fat storage capacity in AT due to this adaptive response may decrease the spillover of lipids from subcutaneous fat and prevent ectopic fat deposition and metabolic dysfunction . In line with this, we recently reported that a PD can reduce liver fat after both short‐ and long‐term intervention in postmenopausal women with obesity .…”
Section: Discussionmentioning
confidence: 83%
“…A Table 4 Inflammatory markers in plasma and subcutaneous adipose tissue lower insulin dose and a lower glucose target during the clamp studies might have detected more subtle changes in hepatic insulin sensitivity. Indeed, we have previously demonstrated an improvement in HOMA-IR after 5 weeks and 6 months following a Paleolithic diet in healthy overweight participants [8,9]. Another limitation is that we had to exclude soleus muscle measurements from three participants because we could not separate the intramyocellular and extramyocellular lipid signals.…”
Section: Discussionmentioning
confidence: 99%
“…Notably, there are conflicting data regarding the effect of macronutrient composition on ectopic fat [3][4][5][6][7]. Two recent studies on obese postmenopausal women found that a Paleolithic diet consumed ad libitum with a moderately decreased carbohydrate intake and a high content of mono-and polyunsaturated fatty acids effectively reduced liver fat [8,9]. Furthermore, a Paleolithic diet efficiently improved glucose tolerance in overweight individuals and in people with type 2 diabetes [10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Such measures have been used to assess racial differences in the prevalence of hepatic steatosis and the technique has also been applied in a population of over 2000 participants[100,101]. Simpler lipid-to-water resonance ratios have been used to compare hepatic steatosis between obese and lean individuals and have demonstrated a change in intrahepatic lipid in response to dietary intervention[102-104]. 1 H MRS also has also been applied to the assessment of steatosis in living-donor liver transplantation[105] and for quantification of steatosis in HIV mono-infected individuals who are at greater risk of liver fibrosis and cirrhosis[106].…”
Section: Imaging-based Modalities As Alternatives To Biopsymentioning
confidence: 99%