Strong anti-polyelectrolyte zwitterionic hydrogels with superior self-recovery, tunable surface friction, conductivity, and antifreezing properties

Xiao, Shengwei; He, Xiaomin; Zhao, Zhiqiang; Huang, Guobo; Yan, Zhenzhong; He, Zhicai; Zhao, Zhengping; Chen, Feng; Yang, Jintao

doi:10.1016/j.eurpolymj.2021.110350

Cited by 34 publications

(23 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In detail, APE refers to the phenomenon in which inter- and intrapolymer interactions are weakened, resulting in swelling and considerable hydration at high ionic strengths (Figure b) . State-of-the-art APE research has engineered the friction coefficients of the polymer brush, , volumetric variations of the hydrogel, , and in vitro antifouling of the polymer . Further, APE actuation could be exploited in vivo to achieve an enhanced antifouling effect because body fluids are rich in ions.…”

mentioning

confidence: 99%

Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

et al. 2021

View full text Add to dashboard Cite

Zwitterionic polymers have extraordinary properties, that is, significant hydration and the so-called antipolyelectrolyte effect, which make them suitable for biomedical applications. The hydration induces an antifouling effect, and this has been investigated significantly. The antipolyelectrolyte effect refers to the extraordinary ion-responsive behavior of particular polymers that swell and hydrate considerably in physiological solutions. This actuation begins to attract attention to achieve in vivo antifouling that is challenging for general polyelectrolytes. In this study, we established the sophisticated cornerstone of the antipolyelectrolyte effect in detail, including (i) the essential parameters, (ii) experimental verifications, and (iii) effect of improving antifouling performance. First, we find that both osmotic force and charge screening are essential factors. Second, we identify the antipolyelectrolyte effect by visualizing the swelling and hydration dynamics. Finally, we verify that the antifouling performance can be enhanced by exploiting the antipolyelectrolyte effect and report reduction of 85% and 80% in ex and in vivo biofilm formation, respectively.

show abstract

mentioning

confidence: 99%

Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

et al. 2021

View full text Add to dashboard Cite

show abstract

“…On the premise of keeping enough antifouling properties, other functional groups which can be used to stabilize polymer networks are also gradually introduced to enhance zwitterionic hydrogels. There are two main categories: (1) introducing hydrophobic groups/intermolecular hydrogen-bond formation moieties into zwitterionic side-chain ( Figure 5 c) [ 54 , 55 , 56 , 57 ]; (2) copolymerization of zwitterionic monomers with different functional monomers ( Figure 5 d) [ 44 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. At present, through the selection of different monomers, zwitterionic hydrogels have been able to achieve various aspects of strength and elasticity regulation to promote their application.…”

Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

View full text Add to dashboard Cite

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

show abstract

“…Even the polymers with a similar charge density of cationic group and anionic group (pSBMA) [ 31 ], which is easier to form self-association and respond to external stimuli, the dipole–dipole interaction between zwitterionic polymer units cannot provide enough mechanical energy dissipation, resulting in the lack of mechanical properties of hydrogels. In addition, as the ion concentration increases, the counterions in the solution bind with the polyions, further destroying the dipole–dipole interaction between the zwitterionic units and extending the polymer chain [ 3 , 17 ]. The resulting zwitterionic hydrogels continue to swell, becoming brittle.…”

Section: Characteristics Of Zwitterionic Hydrogelsmentioning

confidence: 99%

“…Hydrogels, as composites of liquid water and solid polymer networks, have many potential applications in biomedicine engineering [ 1 ], biosensors [ 2 ], and flexible electrolytes [ 3 ]. However, their mechanical properties are limited [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Mechanical Reinforcement of Zwitterionic Hydrogels

Lin

Wei

Liu

et al. 2022

Gels

View full text Add to dashboard Cite

As a nonspecific protein adsorption material, a strong hydration layer provides zwitterionic hydrogels with excellent application potential while weakening the interaction between zwitterionic units, leading to poor mechanical properties. The unique anti-polyelectrolyte effect in ionic solution further restricts the application value due to the worsening mechanical strength. To overcome the limitations of zwitterionic hydrogels that can only be used in scenarios that do not require mechanical properties, several methods for strengthening mechanical properties based on enhancing intermolecular interaction forces and polymer network structure design have been extensively studied. Here, we review the works on preparing tough zwitterionic hydrogel. Based on the spatial and molecular structure design, tough zwitterionic hydrogels have been considered as an important candidate for advanced biomedical and soft ionotronic devices.

show abstract

Strong anti-polyelectrolyte zwitterionic hydrogels with superior self-recovery, tunable surface friction, conductivity, and antifreezing properties

Cited by 34 publications

References 40 publications

Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Recent Advances in Mechanical Reinforcement of Zwitterionic Hydrogels

Contact Info

Product

Resources

About