Strong association between corticosterone and temperature dependent metabolic rate in individual zebra finches

Jimeno, Blanca; Hau, Michaela; Verhulst, Simon

doi:10.1242/jeb.166124

Cited by 45 publications

(54 citation statements)

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“…SI‐CORT concentrations did not differ between years (2014 vs. 2015). This was found both on a between‐individual level (Jimeno, Briga, et al., ; Jimeno, Hau, et al., ) as well as within‐individuals, and irrespective of sex (Figure S2). Furthermore, the difference in SI‐CORT between the first and the second year (SI‐CORT in 2015—SI‐CORT in 2014) was not related to age at first sampling, with no differences between sexes (Figure S3).…”

Section: Resultsmentioning

confidence: 72%

“…Data are archived in the Dryad Digital Repository https://doi.org/10.5061/dryad.c0g0b (Jimeno, Briga, Hau, & Verhulst, ).…”

Section: Data Accessibilitymentioning

confidence: 99%

“…Glucocorticoids (GCs) have diverse physiological functions, depending in part on their plasma concentrations. Baseline levels of GCs exhibit daily and seasonal variation (Monaghan & Spencer, ; Romero, ) in concordance with variation in metabolism and activity levels (Jimeno, Hau, & Verhulst, ), and as such baseline GC levels are viewed as an indicator of allostatic load (Hau et al., ; McEwen & Wingfield, ; Monaghan & Spencer, ; Romero, ). GC concentrations can also increase within minutes in response to acute challenges, inducing physiological and behavioural processes characteristic of an “emergency state” (Wingfield et al., ).…”

Section: Introductionmentioning

confidence: 95%

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Male but not female zebra finches with high plasma corticosterone have lower survival

et al. 2017

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The glucocorticoid axis is essential for coping with predictable and unpredictable environmental variation. Despite this vital function, attempts to link individual variation in the glucocorticoid axis to survival have yielded mixed results, which may be due to endocrine variation caused by uncontrolled variation in environment and life‐history traits such as reproductive effort. We therefore studied the link between the glucocorticoid axis and long‐term survival using captive non‐breeding zebra finches. We quantified the relationship between survival over a three‐year period and plasma corticosterone concentrations: (1) baseline, (2) stress‐induced, (3) after induction of negative feedback via dexamethasone injection and (4) after maximal adrenal stimulation via adrenocorticotropin hormone injection. Only stress‐induced corticosterone predicted survival, with higher concentrations being associated with lower survival. However, this effect differed significantly between the sexes, being present only in males. Stress‐induced corticosterone concentration is the sum of baseline corticosterone and the corticosterone increase in response to the standardized stressor, and both components were similarly associated with male survival in a model that included both variables. This implies that baseline corticosterone itself also exerts an effect on male survival, but this was only revealed when the stress‐induced corticosterone increase was included in the model, presumably because this increased statistical power. Given that corticosterone concentrations are highly repeatable in our study population and independent of manipulated foraging conditions, these data suggest that endocrine stress reactivity may be a major component determining male life span, presumably also in wild populations. A http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.13021/suppinfo is available for this article.

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Section: Resultsmentioning

confidence: 72%

“…Data are archived in the Dryad Digital Repository https://doi.org/10.5061/dryad.c0g0b (Jimeno, Briga, Hau, & Verhulst, ).…”

Section: Data Accessibilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Male but not female zebra finches with high plasma corticosterone have lower survival

et al. 2017

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“…Baseline corticosterone levels are often related to breeding performance in wild vertebrates (reviewed in Bonier et al, ), and especially in chick‐rearing black‐browed albatrosses (Angelier et al, ). Corticosterone is closely linked to energy regulation (Jimeno, Hau, & Verhulst, ) and elevated corticosterone levels are often related with high energetic constraints (Angelier, Wingfield et al, ; Lynn et al, ), especially in black‐browed albatrosses (Angelier et al, ), and they are therefore often a reliable proxy of a low ability of an individual to cope with its environment (Angelier & Wingfield, , but see Bonier et al, ). Recently, there has been a growing interest in the link between glucocorticoids levels and telomere dynamics in wild vertebrates (Angelier et al, ; Monaghan, ).…”

Section: Discussionmentioning

confidence: 99%

Is telomere length a molecular marker of individual quality? Insights from a long‐lived bird

et al. 2019

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In wild vertebrates, some individuals survive and reproduce better than others and this has led to the concept of individual quality. Despite its importance when studying ecological processes and life‐history trade‐offs, measuring individual quality is complex because individuals must be followed during a large part of their life. Recently, telomere biology has been successfully brought into ecology and telomere length has been suggested to be a promising molecular tool to evaluate individual quality in wild vertebrates (“the telomere–individual quality hypothesis”). In this study, we tested this hypothesis in a long‐lived species, the black‐browed albatross (Thalassarche melanophrys) by simultaneously measuring telomere length and several potential complementary phenotypic proxies of individual quality in a single year. In addition, we followed the return rate and the reproductive performance of these same albatrosses for a decade. We found that long telomeres were associated with several markers of high individual quality (foraging behaviour, body size and stress hormone levels). Furthermore, we found that a single measure of telomere length could predict future offspring productivity, for at least several years following telomere measurement (better productivity being associated with longer telomeres). Altogether, these results support the “telomere–individual quality hypothesis” and suggest that telomere length can be useful to estimate individual quality in long‐lived seabirds. A plain language summary is available for this article.

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“…In earlier experiments we have found that at 5 days post-fertilisation (dpf) baseline cortisol levels are increased following cortisol treatment for 6 hours post fertilisation (hpf) but not following dexamethasone (a potent GR-agonist (Rupprecht et al, 1993) to assess the role of GR more specifically) treatment (Althuizen, 2018;van den Bos et al, 2019a), suggesting a higher hypothalamus-pituitary-interrenal cells (HPI-axis) activity. Higher cortisol levels have been shown to be associated with increased respiration rate (oxygen consumption and CO 2 production) and plasma glucose levels through stimulation of GR (De Boeck et al, 2001;Jimeno et al, 2017Jimeno et al, , 2018Wendelaar Bonga, 1997). Hence, we hypothesized that oxygen consumption and gene-expression were stronger in cortisol-treated than in control-treated or dexamethasone-treated subjects at 5 dpf.…”

Section: Introductionmentioning

confidence: 99%

Effects of early life glucocorticoid exposure on metabolism in zebrafish (Danio rerio) larvae

R¹

2019

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van den Bos: metabolism in embryos and larvae following early-life exposure to glucocorticoids Abstract (number of words: 265)In this study we assessed the effects of increased cortisol levels during early embryonic development (0-6 hours post-fertilisation (hpf)), thereby mimicking maternal stress, on metabolism in zebrafish (Danio rerio) larvae. In two series of experiments fertilized eggs were exposed to a cortisol-containing, a dexamethasone-containing (to stimulate the glucocorticoid receptor (GR) specifically) or a control medium for 6 hours post-fertilisation (0-6 hpf). In the first series we measured oxygen consumption as a proxy for metabolism, in the second series gene-expression of genes related to gluconeogenesis and glucose transport. Previously we have found that at 5 days post-fertilisation (dpf) baseline cortisol levels are increased following cortisol pre-treatment but not following dexamethasone pre-treatment, suggesting a higher hypothalamus-pituitary-interrenal cells (HPI-axis) activity. Hence, we hypothesized that oxygen consumption and gene-expression were stronger in cortisol-treated than in dexamethasone-treated and control-treated subjects at 5 dpf. Indeed, we observed increased oxygen consumption in cortisol-treated subjects compared to dexamethasone-treated or control-treated subjects. However, gene-expression levels were not different between treatments, which may have been due to a developmental delay in this second series. We also reasoned that both cortisol-treated and dexamethasone-treated subjects would show a higher metabolism at 1 dpf than control-treated subjects as the HPI-axis is not functional as yet and more general processes are being stimulated by cortisol through GR stimulation. Indeed, we observed increased oxygen consumption and increased expression of genes related to gluconeogenesis and glucose transport in cortisol-treated and dexamethasone-treated subjects than control-treated subjects. These data show that early-life exposure to cortisol, mimicking thereby maternal stress, increased metabolism at different life stages, i.e. 1 and 5 dpf, involving the GR. van den Bos: metabolism in embryos and larvae following early-life exposure to glucocorticoids The author received no specific funding for this research. ReferencesAlderman SL, Bernier NJ (2009). Ontogeny of the corticotropin-releasing factor system in zebrafish. Alsop D, Vijayan MM (2008). Development of the corticosteroid stress axis and receptor expression in zebrafish. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 294(3): R711-R719. Althuizen J (2018). Development in AB and TL zebrafish (Danio rerio) is affected by early-life exposure to cortisol and dexamethasone. MSc thesis Radboud University Best C, Kurrasch DM, Vijayan MM (2017). Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Scientific reports 7: 40905 (doi.org/10.1038/srep40905) Chatzopoulou A, Roy U, Meijer AH, Alia A, Spaink HP, Schaaf MJM (2015). Transcriptional and metabolic e...

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Strong association between corticosterone and temperature dependent metabolic rate in individual zebra finches

Cited by 45 publications

References 45 publications

Male but not female zebra finches with high plasma corticosterone have lower survival

Male but not female zebra finches with high plasma corticosterone have lower survival

Is telomere length a molecular marker of individual quality? Insights from a long‐lived bird

Effects of early life glucocorticoid exposure on metabolism in zebrafish (Danio rerio) larvae

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