Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures

Xu, Hockin H.K.; Burguera, Elena F.; Carey, Lisa E.

doi:10.1016/j.biomaterials.2007.05.015

Cited by 81 publications

(61 citation statements)

References 46 publications

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“…The reduction in the compressive strength was apparently due to the increase in the porosity. 7),13) However, these compressive strengths are comparable to those reported in the literature, 5),7), 9) indicating that the porous CPCs produced using gelatin as the porogen should find very useful applications in bone tissue engineering, in which interconnected pores are required for favorable bone ingrowth.…”

Section: Resultssupporting

confidence: 57%

Fabrication of porous calcium phosphate cements using gelatin as porogen

Lee

Kim

Koh

2010

J. Ceram. Soc. Japan

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Porous calcium phosphate cements (CPCs) were fabricated using gelatin granules as the porogen. As the amount of gelatin was increased from 0 to 43 vol%, the porosity notably increased from 3 to 47 vol%, while the compressive strength decreased from 23 to 14 MPa; however, these values are still expected to be reasonably high for applications in bone tissue engineering. In addition, osteoblastic cells grew favorably on the surfaces of the CPCs prepared using gelatin of 11 and 43 vol%, which contained well interconnected pores with a size of several hundreds of microns, indicating excellent biocompatibility of the porous CPC samples produced in this study.

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Section: Resultssupporting

confidence: 57%

Fabrication of porous calcium phosphate cements using gelatin as porogen

Lee

Kim

Koh

2010

J. Ceram. Soc. Japan

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“…as reviewed by Canal et al (Canal & Ginebra 2011). These approaches have allowed either an increase of the mechanical properties (Zhang & Xu 2005) or to couple good mechanical properties and macroporosity, increasing the degradation rate and allowing cell infiltration in the material (Xu et al 2006;Xu et al 2007). Nonetheless, up to now, little attention has been paid to the fiber-matrix adhesion, which is crucial for a successful load transfer, a prerequisite for an effective reinforcement (Nelson et al 2002).…”

Section: Introductionmentioning

confidence: 99%

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

Gallinetti

Mestres

Canal

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to nonload-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiberreinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line. Graphical Abstract (for review) Highlights HIGHLIGHTS• Calcium phosphate cements were reinforced with chitosan fibers and soluble chitosan• The chemical affinity of fibers and matrix improved interfacial adhesion• Mechanical reinforcement was achieved thanks to a good fiber-matrix adhesion• Fiber-reinforced cements were significantly tougher than non-reinforced analogues • The modified cement matrix supported osteoblast proliferation 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 -2 - AbstractCalcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to non-load-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiber-reinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line.

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“…The rationale for such construction was for the macroporous layer to accept tissue ingrowth, while the fiber-reinforced strong layer would provide the needed early-strength [597].…”

Section: Future Developmentsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures

Cited by 81 publications

References 46 publications

Fabrication of porous calcium phosphate cements using gelatin as porogen

Fabrication of porous calcium phosphate cements using gelatin as porogen

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

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