Strong underwater adhesion of injectable hydrogels triggered by diffusion of small molecules

Su, Xing; Xie, Wenyue; Wang, Pudi; Tian, Zhuoling; Wang, Hao; Yuan, Zuoying; Liu, Xiaozhi; Huang, Jianyong

doi:10.1039/d1mh00533b

Cited by 68 publications

(56 citation statements)

References 58 publications

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“…For instance, Fujita et al [12] designed a catechol-functionalized oxime hydrogel for preventing post-surgical cardiac adhesions. Su et al [13] developed an injectable gelatin hydrogel functionalized by tea polyphenols through a complete physical crosslinking strategy using urea as a crosslinking agent. The functionalized gelatin hydrogel shows intelligent adhesion effects on various materials, such as glass and pig skin, in different water environments.…”

Section: Introductionmentioning

confidence: 99%

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

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The goal of regenerative wound healing dressings is to restore tissue function back to normal physiological activity and accelerate skin tissue regeneration at wound sites. The optimal strategy to achieve this purpose requires a balance between material functionality, degradation, safety, and tissue regrowth. Herein, for the first time, an ultrasonic-triggered irreversible tending to equilibrium self-assembly and ionic cross-linking codriven strategy is proposed for producing multifunctional cinnamaldehyde-tannic acid-zinc acetate nanospheres (CA-TA-ZA NSs), realizing the fusion of hydrophilic and hydrophobic drug-food small molecules. Moreover, a novel "all-in-one" chitosan (CS)-based hydrogel functionalized by introducing drug-food small molecules self-assembled CA-TA-ZA NSs to the 3D network structures of CS is designed, integrating excellent antibacterial, antioxidant, anti-inflammatory and reducing oxidative stress damage abilities. Additionally, the multifunctional CS-based hydrogel can realize rapid in situ gelation at wound sites and completely cover the irregular wounds. All of these superiorities enable the CS-based hydrogel to clean the wound microenvironment, induce skin tissue remodeling, promote blood vessel repair and hair follicle regeneration, restore the immune system back to normal physiological activity, and accelerate wound healing. Therefore, this study offers a new perspective for the design of advanced functional materials with great application potential in the biomedical field.

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Section: Introductionmentioning

confidence: 99%

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Sun

Jia

Zhang

et al. 2021

Adv Funct Materials

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“…The ultrastrong interfacial adhesion of PAA–Fe–Li to diverse hydrogel substrates was dominated by hydrogen bonding between carboxyl groups in PAA–Fe–Li and functional groups in the hydrogel substrates (e.g., amide groups in PAAm, hydroxyl groups in PVA or PAAm–Alg–Ca, carboxyl groups in PAA or PAAm–Alg–Ca, quaternary amine groups in PAAm–DAC, sulfonate acid groups in PAAm–AMPS–Zr). [ 39 ] This point was confirmed by employing urea, which was known as an effective hydrogen bonding dissociator, [ 37 ] to treat the adhesion interfaces (Table S5, Supporting Information). Also, electrostatic attraction between negatively charged carboxyl groups in PAA–Fe–Li and positively charged quaternary amine groups in PAAm–DAC might contribute to the interfacial adhesion (Table S5, Supporting Information).…”

Section: Resultsmentioning

confidence: 97%

“…Knowing the Li + content in the soaked hydrogel samples, C i ( i = 1, 2, 3… N ) in N groups representing the Li + concentrations of LiCl solutions can be obtained. [ 37 ] By conducting finite element method (FEM) model calculations, c i ( i = 1, 2, 3… N ) representing the corresponding Li + concentrations of hydrogel samples can also be quantified as

c_{i} = \underset{normalΩ}{∭} c_{ion} normald normalΩ normal/ V_{gel}

where Ω indicates the hydrogel region and V gel represents the volume of hydrogel samples. By comparing the experimental data and those acquired by the FEM model based on the following formula

R^{2} = \arg \max ([], 1 - \frac{\sum_{i = 1}^{N} (c_{i} - C_{i})}{\sum_{i = 1}^{N} (c_{i} - \bar{C})})

with

\bar{C} = \sum_{i = 1}^{N} C_{i} / N

, we can readily determine the diffusion coefficient of Li + in hydrogels in situ as D PFL = 1.5 × 10 −14 m 2 s −1 and D PVA = 8 × 10 −13 m 2 s −1 .…”

Section: Resultsmentioning

confidence: 99%

“…Knowing the Li + content in the soaked hydrogel samples, C i (i = 1, 2, 3…N) in N groups representing the Li + concentrations of LiCl solutions can be obtained. [37] By conducting finite element method (FEM) model calculations, c i (i = 1, 2, 3…N) representing the corresponding Li + concentrations of hydrogel samples can also be quantified as…”

Section: Mechanoelectric Coupling Model Of Electrically Programmable ...mentioning

confidence: 99%

“…e) Strong adhesion (>5 kg) demonstration between PAA-Fe-Li and PVA, where the adhesion interface diameter was 6 mm. The PAA-Fe-Li and PVA hydrogels had been adhered for 24 h. f) Adhesive strength of PAA-Fe-Li hydrogels compared to other soft material adhesives, whose adhered substrates were biological tissues (orange),[7,15,37,[40][41][42][43] hydrogels (purple),[10,20,44,45] and elastomers (blue) [19]. g) Comparison of adhesion performance between the proposed electroadhesion strategy and existing hydrogel-hydrogel adhesion strategies reported in the literature [2,10,11,13,…”

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confidence: 99%

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Electrically Programmable Interfacial Adhesion for Ultrastrong Hydrogel Bonding

Liu

Wang

et al. 2022

Advanced Materials

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Adjustable interfacial adhesion is of great significance in smart‐hydrogel‐related engineering fields. This study presents an electroadhesion strategy for universal and ultrastrong hydrogel bonding with electrically programmable strength. An ionic hydrogel containing lithium ions is designed to achieve hydrated‐ion‐diffusion‐mediated interfacial adhesion, where external electric fields are employed to precisely control spatiotemporal dynamics of the ion diffusion across ionic adhesion region (IAR). The hydrogel can realize a universal, ultrastrong, efficient, tough, reversible, and environmentally tolerant electroadhesion to diverse hydrogels, whose peak adhesion strength and interfacial adhesion toughness are as high as 1.2 MPa and 3750 J m−2, respectively. With a mechanoelectric coupling model, the dominant role of the hydrated ions in IAR played in the interfacial electroadhesion is further quantitatively revealed. The proposed strategy opens a door for developing high‐performance adhesion hydrogels with electrically programmable functions, which are indispensable for various emerging fields like flexible electronics and soft robotics.

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Design of Double‐Network Click‐Gels for Self‐Contained Underwater Adhesion and Energy‐Wise Applications in Floating Photovoltaics

Wang

et al. 2022

Adv Funct Materials

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Facile fabrication of rapid, firm, and reversible underwater adhesion used on different adherets is challenging but is of primary importance for many industrial and biomedical applications. Herein, tough, stretchy, moldable, and semitransparent gels are developed for self‐contained underwater adhesives. The selected structural components, well‐defined double‐network (DN) structures, and one‐pot synthesis realize synergistic adhesion and cohesion engineering, which deliver instant, solid, reversible, and long‐term adhesives with a high underwater adhesion strength of over 0.84 MPa. The underwater adhesion strength is among the best‐performing tape‐type underwater adhesives. In order to develop new energy‐related applications for underwater adhesion, the first example of combining underwater adhesion with solar power applications is demonstrated. Taking the benefits of the direct‐contact design at the air/water interface, the click‐gel‐mounted floating photovoltaic (FPV) system significantly increases the power conversion efficiency by 20% due to the enhanced active cooling effects, surpassing several conventional photovoltaic technologies on both land and water. The click‐gel also rapidly responds to several oscillatory motions on the FPV platform. This study shines a light on the facile fabrication of DN click‐gels for underwater adhesives and provides their future perspectives in energy‐wise, low‐maintenance, and stimuli‐responsive applications.

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Strong underwater adhesion of injectable hydrogels triggered by diffusion of small molecules

Abstract: It is challenging for injectable hydrogels to achieve high underwater adhesiveness. Based on this concern, we report a fully physically crosslinked injectable hydrogel composed of gelatin, tea polyphenols and urea,...

Cited by 68 publications

References 58 publications

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Electrically Programmable Interfacial Adhesion for Ultrastrong Hydrogel Bonding

Design of Double‐Network Click‐Gels for Self‐Contained Underwater Adhesion and Energy‐Wise Applications in Floating Photovoltaics

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