Stronger functional network connectivity and social support buffer against negative affect during the COVID-19 outbreak and after the pandemic peak

Xiao, Mingzhao; Chen, Ximei; Yi, Haijing; Luo, Yong; Yan, Qiaoling; Feng, Tingyong; He, Qinghua; Lei, Xu; Qiu, Jiang; Chen, Hong

doi:10.1016/j.ynstr.2021.100418

Cited by 14 publications

(6 citation statements)

References 101 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since several of these symptoms suggest cognitive abnormalities among survivors, most contemporary neuroimaging studies have turned their attention to behavioral correlates of functional brain alterations, primarily, post-traumatic stress syndromes (Benedetti et al, 2021; Fu et al, 2021). On the other hand, several others have attempted to use functional connectivity (FC) as a neurobiological indicator of higher stress levels (Liu et al, 2021; Perica et al, 2021), depression (Zhang et al, 2022) and negative affect (Xiao et al, 2021) among only healthy subjects before and after the pandemic.…”

Section: Introductionmentioning

confidence: 99%

“…Most contemporary neuroimaging studies have mainly focused on brain correlates of post-traumatic stress syndromes (Benedetti et al, 2021; Fu et al, 2021). On the other hand, several others have attempted to use FC as a neurobiological indicator of higher stress levels (Liu et al, 2021; Perica et al, 2021), depression (Zhang et al, 2022) and negative affect (Xiao et al, 2021) among healthy subjects before and after the pandemic. Despite fatigue being the most frequently reported symptom, very little is known of its brain related effects among survivors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients

Hafiz

Gandhi

Misrhra

et al. 2022

Preprint

View full text Add to dashboard Cite

The recent Coronavirus Disease 2019 (COVID-19) has affected all aspects of life around the world. Neuroimaging evidence suggests the novel coronavirus can attack the central nervous system (CNS), causing cerebro-vascular abnormalities in the brain. This can lead to focal changes in cerebral blood flow and metabolic oxygen consumption rate in the brain. However, the extent and spatial locations of brain alterations in COVID-19 survivors are largely unknown. In this study, we have assessed brain functional connectivity (FC) using resting-state functional MRI (RS-fMRI) in 38 (25 males) COVID patients two weeks after hospital discharge, when PCR negative and 31 (24 males) healthy subjects. FC was estimated using independent component analysis (ICA) and dual regression. The COVID group demonstrated significantly enhanced FC in regions from the Occipital and Parietal Lobes, comparing to the HC group. On the other hand, the COVID group exhibited significantly reduced FC in several vermal layers of the cerebellum. More importantly, we noticed negative correlation of FC with self-reported fatigue within regions from the Parietal lobe, which are known to be associated with fatigue. Keywords: COVID, Functional Connectivity, ICA, Fatigue, RS-fMRI

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients

Hafiz

Gandhi

Misrhra

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, active measures should be taken to make a range of social support resources available to individuals suffering from social disconnectedness in order to reduce the negative impact of the pandemic on psychological well-being [ 38 ]. People also should facilitate connectedness among family members and friends, increase opportunities for social interactions, since family support could reduce perceived isolation and increase the level of life satisfaction during the pandemic [ 16 ]. Secondly, our results showed that COVID-19 related concerns aggravated the relationship between social disconnectedness and mental health problems, suggesting that special attention should be paid to alleviate unnecessary concerns about the pandemic.…”

Section: Discussionmentioning

confidence: 99%

“…Distinct from social disconnectedness, perceived isolation is the subjective sense of a lack of social resources and network functioning [ 15 ], which includes feelings of loneliness and a perceived loss of social relations. Despite that social contact with others and participation in social activities declined during the COVID-19 pandemic due to shelter-in-place and stay-at-home orders, many individuals developed closer relationships with family members and friends and perceived relatively stronger social support [ 16 ]. Individuals’ object levels of social disconnectedness can be totally irrelevant to their perceptions of social isolation and loneliness.…”

Section: Introductionmentioning

confidence: 99%

Social Disconnectedness and Mental Health Problems During the COVID-19 Pandemic in China: A Moderated Mediation Model

Xiong¹,

Xia

Beihai

2022

Int J Public Health

View full text Add to dashboard Cite

Objectives: This study aimed to examine the mediating effect of perceived isolation and the moderating effect of COVID-19 related concerns in the relationship between social disconnectedness and mental health problems during the COVID-19 pandemic in China.Methods: A cross-sectional online survey of 11,682 Chinese residents were conducted during the COVID-19 outbreak. Conditional process analysis was performed to test the mediating effect of perceived isolation and the moderating effect of COVID-19 related concerns.Results: Social disconnectedness was positively related to mental health problems, and perceived isolation significantly mediated their relationship. COVID-19 related concerns exacerbated the direct link between social disconnectedness and mental health problems as well as the indirect link via perceived isolation.Conclusion: Social disconnectedness was a key predictor of mental health problems during the COVID-19 outbreak. The direct and indirect effects of social disconnectedness on mental health problems were stronger for respondents who had more COVID-19 related concerns. Understanding the underlying mechanisms by which social disconnectedness is related to mental health problems has important practical implications for the prevention of mental health problems during the COVID-19 pandemic.

show abstract

“…Research in health psychology and social neuroscience indicate an urgent need to understand how social support is related to whole-brain connectivity (Xiao et al, 2021). This endeavor involves linking many strands of research; to date, studies have connected perceived social support to wellbeing (Cohen, 2004; Williams et al, 2018), experience in the environment to brain network organization (Chan et al, 2018; Ellwood-Lowe et al, 2021), and the social world to the brain (Krendl and Betzel, 2022; Schmälzle et al, 2017; Morawetz et al, 2021; Rudolph et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Stability of brain-behavior correlation patterns across measures of social support

Merritt

Faskowitz

Gonzalez

et al. 2023

Preprint

View full text Add to dashboard Cite

The social environment has a critical influence on human development, cognition, and health. By using network approaches to map and analyze the connectivity between all pairs of brain regions simultaneously, we can clarify how relationships between brain regions (e.g. connectivity) change as a function of social relationships. Here we apply multilayer modeling and modularity maximization--both established tools in network neuroscience--to jointly cluster patterns of brain-behavior associations for seven social support measures. Our analyses build on both neuroecological findings and network neuroscientific approaches. In particular we find that subcortical and control systems are especially sensitive to different constructs of perceived social support. Network nodes in these systems are highly flexible; their community affiliations, which reflect groups of nodes with similar patterns of brain behavior associations, differ across social support measures. The multilayer approach used here enables direct comparison of the roles of all regions of the brain across all social support measures included. Additionally, our application of multilayer modeling to patterns of brain-behavior correlations, as opposed to just functional connectivity, represents an innovation in how multilayer models are used in. More than that, it offers a generalizable technique for studying the stability brain-behavior correlations.

show abstract

Stronger functional network connectivity and social support buffer against negative affect during the COVID-19 outbreak and after the pandemic peak

Cited by 14 publications

References 101 publications

Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients

Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients

Social Disconnectedness and Mental Health Problems During the COVID-19 Pandemic in China: A Moderated Mediation Model

Stability of brain-behavior correlation patterns across measures of social support

Contact Info

Product

Resources

About