Using an ultracold gas of atoms, we have realized a quasi-two-dimensional Fermi system with widely tunable s-wave interactions nearly in a ground state. Pressure and density are measured. The experiment covers physically different regimes: weakly and strongly attractive Fermi gases and a Bose gas of tightly bound pairs of fermions. In the Fermi regime of weak interactions, the pressure is systematically above a Fermi-liquid-theory prediction, maybe due to mesoscopic effects. In the opposite Bose regime, the pressure agrees with a bosonic mean-field scaling in a range beyond simplest expectations. In the strongly interacting regime, measurements disagree with a purely 2D model. Reported data may serve for sensitive testing of theoretical methods applicable across different quantum physics disciplines. Two-dimensional many-body quantum systems show interesting physics and are technologically important. In 2D the phenomena of superfluidity and Bose condensation become clearly separated [1]. High-temperature superconductivity is attributed to the 2D structure of the materials [2]. Semiconductor and oxide interfaces containing 2D electron gas are important for modern and prospective electronics [3,4].The concept of a Bardeen-Cooper-Schrieffer (BCS) to Bose-Einstein-condensate (BEC) crossover [5,6] gives a unified view at some Fermi and Bose systems: By varying interactions, a gas of fermions obeying the BCS or similar model may be smoothly converted into a gas of pointlike bosons, which are pairs of the initial fermions. Such a crossover has been predicted for excitons [7] and quarks [8] and realized in a 3D gas of ultracold fermionic atoms with s-wave interactions [9]. Measurements on this system have stimulated development of the many-body quantum theory [5,6], especially for the challenging regime of strong interactions which lies between the BCS and Bose asymptotes.The 2D BCS-BEC crossover for fermions with s-wave interactions is the focus of this Letter. The strongly interacting regime of this crossover may be relevant to hightemperature superconductors: While the superconducting phase of the cuprates has d-wave symmetry [2], the s-wave symmetry has been detected in the pseudogap phase [10]. Exploring the Bose part of the crossover complements studies of interacting 2D Bose gases [11] by reaching stronger interactions. Studying the fermionic side may add to the understanding of 2D Fermi liquids. Failure of the meanfield description is an example of theoretical challenges in 2D: In 3D the BCS-BEC crossover is qualitatively modeled by a mean field of Cooper pairs (Fig. 5 of Ref. [5]), while in 2D a similar model is qualitatively incorrect, predicting an interaction-independent equation of state at zero temperature [12].The pure 2D paradigm assumes motion strictly in the xy plane and no z dependence in interactions. In reality, particles experience zero-point oscillations along z and interact via 3D potentials. The term "quasi-2D" generally indicates some departure from the pure 2D approximation while the kinematic...