Strontium-90 Induced Bone Tumours in Beagle Dogs: Effects of Route of Exposure and Dose Rate

Gillett, Nancy A.; Pool, Roy R.; Taylor, Glenn N.; Muggenburg, B.A.; Boecker, B.B.

doi:10.1080/09553009214551701

Cited by 9 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At Although the liver neoplasms observed in dogs exposed by inhalation to '~CeCl3 were not different in appearance from spontaneously occurring hepatic tumors, the very high incidence of these tumors and the preponderance of hemangiosarcomas along with the (3 dose to the liver suggest a causal relationship between 144Ce exposure and the occurrence of liver tumors. In addition, hemangiosarcomas of several organs have been induced in dogs by internally deposited (3-emitting radionuclides, including lung (13), lymph nodes (15), bone (1,12), and bone-associated mucosa (1), as well as liver. These reports emphasize the association of 13 irradiation with hemangiosarcoma of numerous tissues.…”

Section: Methodsmentioning

confidence: 99%

Hepatic Neoplasms from Internally Deposited 144CeCl3

Hahn¹,

Muggenburg²,

Boecker³

1996

Toxicol Pathol

View full text Add to dashboard Cite

Fifty-five dogs were exposed by inhalation to graded activity levels of 144 CeCl 3 , a relatively soluble form of the β-emitting radionuclide. A large portion of the 144 Ce translocated from lung to liver and skeleton. Significant radiation doses were delivered to the respiratory tract, liver, and skeleton; however, the liver received the greatest cumulative absorbed dose. Liver tumors were the most frequently observed neoplasms in these exposed dogs and included 7 primary hepatic hemangiosarcomas, 1 cholangiocarcinoma, 1 hepatocellular carcinoma, 1 fibrosarcoma, 4 biliary cystadenomas, and 1 fibroma. The dose to the liver in these dogs ranged from 11 to 250 Gy with a median of 57 Gy. Autoradiographs showed a relative uniform distribution of & b e t a ; dose to the liver. All the malignant tumors and 1 cystadenoma were primary causes of death. The morphologic features of the hemangiosarcomas and associated hepatic lesions were similar to those described for hemangiosarcomas induced in people exposed to Thorotrast. Biliary cystadenomas were associated with degenerative lesions in the liver but not with other neoplasms in the liver. These results indicate that the liver is an important target organ for effects from internally deposited 144 Ce.

show abstract

Section: Methodsmentioning

confidence: 99%

Hepatic Neoplasms from Internally Deposited 144CeCl3

Hahn¹,

Muggenburg²,

Boecker³

1996

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…When less damage is done to cells or when the damage occurs at a sufficiently low rate that the self-repair mechanisms in the cells prevent the radiation killing the cells then the effect which concerns us most is the modification of the DNA in the cells. It is impossible to argue that ionizing radiation is incapable of inducing cancer, for example internal exposure to 90 Sr induces bone cancer in dogs (Gillett, Pool, Taylor, Muggenburg, & Boecker, 1992) and it is interesting to note that a Scottish industrial radiographer who had a lifetime whole body dose in the range of 10-15 Gy died of a form of leukaemia (acute myeloid) (Lloyd et al, 1994) which is a common second cancer in cancer patients treated with radiotherapy. When the DNA is damaged sometimes the cell will correctly repair it and sometimes during the attempt at repair the cell will fail to repair it correctly.…”

Section: How Dangerous Is Radiationmentioning

confidence: 99%

Reactor accident chemistry an update

Foreman

2018

Cogent Chemistry

View full text Add to dashboard Cite

A review and discussion of some of the literature on the subject of serious nuclear reactor accidents. This review addresses some biological issues such as the influence of dose rate on the ability of radiation to cause harm, the chemistry of a selection of serious accidents and the behaviour of a series of important fission products and the actinides. This review is intended for scientists with a professional interest in nuclear reactors, chemists in general and I expect that it will be of use to historians with an interest in the nuclear industry and its relationship with wider society.

show abstract

Biokinetics of 90Sr after chronic ingestion in a juvenile and adult mouse model

Synhaeve

Stéfani

Tourlonias

et al. 2011

Radiat Environ Biophys

View full text Add to dashboard Cite

The aim of our study was to define the biokinetics of (90)Sr after chronic contamination by ingestion using a juvenile and adult murine model. Animals ingested (90)Sr by drinking water containing 20 kBq l(-1) of (90)Sr. For the juvenile model, parents received (90)Sr before mating and their offspring were killed between birth and 20 weeks of ingestion. For the adult model, (90)Sr ingestion started at 9 weeks of age and they were killed after different ingestion periods up to 20 weeks. The body weight, food and water consumption of the animals were monitored on a weekly basis. Before killing and sampling of organs, animals were put in metabolic cages. (90)Sr in organs and excreta was determined by liquid scintillation β counting. Highest (90)Sr contents were found in bones and were generally higher in females than in males, and (90)Sr retention varied according to the skeletal sites. An accumulation of (90)Sr in the bones was observed over time for both models, with a plateau level at adult age for the juvenile model. The highest rate of (90)Sr accumulation in bones was observed in early life of offspring, i.e. before the age of 6 weeks. With the exception of the digestive tract, (90)Sr was below the detection limit in all other organs sampled. Overall, our results confirm that (90)Sr mainly accumulates in bones. Furthermore, our results indicate that there are gender- and age-dependent differences in the distribution of (90)Sr after low-dose chronic ingestion in the mouse model. These results provide the basis for future studies on possible non-cancerous effects during chronic, long-term exposure to (90)Sr through ingestion in a mouse model, especially on the immune and hematopoietic systems.

show abstract

Strontium-90 Induced Bone Tumours in Beagle Dogs: Effects of Route of Exposure and Dose Rate

Cited by 9 publications

References 15 publications

Hepatic Neoplasms from Internally Deposited 144CeCl3

Hepatic Neoplasms from Internally Deposited 144CeCl3

Reactor accident chemistry an update

Biokinetics of 90Sr after chronic ingestion in a juvenile and adult mouse model

Contact Info

Product

Resources

About