Strontium Chloride: Can It Be a New Treatment Option for Ulcerative Colitis?

Topal, Firdevs; Yönem, Özlem; Tuzcu, Nevin; Tuzçu, Mehmet; Ataseven, Hilmi; Akyol, Melih

doi:10.1155/2014/530687

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…(14) We have planned this study in the light of all this information, we investigated the effect of SR and HPE on inflammation in experimental colitis and compared it with a novel therapeutic agent prednisolone. In our histopathological results, we observed that SR was effective in the cure of colitis, as in Firdevs et al (7). On the other hand, oral application of HPE has been shown to exacerbate inflammation in the colon segments.…”

Section: Discussionsupporting

confidence: 83%

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Effects of strontium ranilate and Hypericum perforatum extract on experimental colitis model in rats

Kurt¹,

Soylu²,

Inal³

et al. 2018

Cumhuriyet Medical Journal

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In this study, we aimed to compare the healing effect of strontium ranilate(SR) and hypericum perfaratum (HPE) with the healing effect of prednisolone used in the treatment of experimental colit in rats. Method: 30 wistar albino rats were used in the study. Rats were randomly assigned to 5 consecutive groups consisting of 5 rats. Group 1, healthy rats, group 2 colitis but untreated rats. The rats in groups 3, 4, and 5 had colitis and received 160 mg / kg SR, 1mg/kg prednisolone and HP extracts containing 0.3% hiperisine (250 uq / 300 mg) by oral gavage, respectively for seven days. At the end of the seventh day, the colons of the rats were removed and histopathological examination was performed. Results: The histopathological results of the HPE group were statistically worst including the control group. It was observed that the best results in the treatment groups were SR group followed by prednisolone group, respectively.(P<0.05) Conclusions: This study concluded that SR was at least as effective as prednisolone in colitis treatment, but HPE exacerbate colitis-induced inflammation when received by orally.

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Section: Discussionsupporting

confidence: 83%

“…It has also been shown that human monocytes perform inflammatory mediator production by suppressing NF-[kappa] B activation (19). In a similar study, Fırdevs T et al (7) found that that strontium chloride has comparable therapeutic efficiency with prednisolone in rat colitis model.…”

Section: Discussionmentioning

confidence: 92%

Effects of strontium ranilate and Hypericum perforatum extract on experimental colitis model in rats

Kurt¹,

Soylu²,

Inal³

et al. 2018

Cumhuriyet Medical Journal

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“…In mice, for example, sodium arsenite was associated with a reduction in the severity of DSS-induced experimental colitis 49 and arsenic trioxide had anti-inflammatory consequences in TNBS-induced colitis 50 . Likewise, preclinical studies using cobalt 51 , lithium 52 , strontium 53 and uranium 54 also found a clear anti-inflammatory potential. Lastly, some preliminary data strongly suggest that mice exposed to methylmercury for 3 weeks are resistant to DSS-associated inflammation (Body-Malapel and Vignal, unpublished data).…”

Section: Discussionmentioning

confidence: 91%

Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology

Breton

Daniel

Vignal

et al. 2016

Sci Rep

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Although the heavy metals cadmium (Cd) and lead (Pb) are known environmental health concerns, their long-term impacts on gut ecology and susceptibility to gastrointestinal autoimmune diseases have not been extensively investigated. We sought to determine whether subchronic oral exposure to Cd or Pb is a risk factor for the development and progression of inflammatory bowel disease (IBD). Mice were exposed to various doses of CdCl2 or PbCl2 in drinking water for 1, 4 or 6 weeks prior to infection with Salmonella, the induction of colitis with dextran sodium sulfate (DSS) or trinitrobenzene sulfonic acid (TNBS). In human cell-based models, exposure to Cd and Pb is associated with reduced transepithelial electric resistance and changes in bacteria-induced cytokine responses. Although 1- and 6-week exposures did not have clear effects on the response to Salmonella infectious challenges, 1-week short-term treatments with CdCl2 tended to enhance intestinal inflammation in mice. Unexpectedly, subchronic exposure to Cd and (to a lesser extent) Pb significantly mitigated some of the symptoms of DSS-induced colitis and reduced the severity of TNBS colitis in a dose-dependent manner. The possible adaptive and immunosuppressive mechanisms by which heavy metals might reduce intestinal inflammation are explored and discussed.

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“…Таким образом, показана способность стронция влиять на важнейшие показатели иммунной регуляции у детского населения при повышенном содержании металла в источниках питьевого водоснабжения. Данные литературы также подтверждают возможность функциональных изменений иммунной реактивности под воздействием стронция [5,6,10]. В нашем исследовании у обследованной группы детского населения выявлены существенные сдвиги параметров как гуморального, так и клеточного звена иммунитета на фоне повышения специфической сенсибилизации к металлу, а также нарушение процесса запуска и регуляции апоптоза.…”

Section: заключениеunclassified

Сhanges of Immunoregulatory Indexes in Children Exposed to Strontium

et al. 2018

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Evaluation of the immune system parameters can be used in order to assess capacity to adapt under conditions of increased external chemical load, including exposure to metals, which can exert either activating and inhibitory effects upon immune regulation parameters. The aim of this work was the analysis of immunoregulatory markers in a children’s population who consumed water with high strontium content (a sample from the Perm region). We carried out immunological evaluation of the children aged 7 to 12 years, living at a territory with a high strontium content in the drinking water. The comparison group included children from the conventionally clean region. We studied differential changes in cellular immunity (phagocytosis rates), humoral factors of immune defense (serum immunoglobulins), development of specific sensitization for strontium, as well as the processes of apoptosis triggering and regulation. A 3.68-fold increase in strontium levels was shown in fresh water within observation area, and the average blood strontium content in the children of appropriate observation group was 1.55-fold higher than in children of the comparison group. At the same time, 1.2-fold increase in phagocytic activity determined as phagocytic number and phagocytic index was found, as compared to the control group. In 80% of the subjects, a reduction in serum IgG level was observed when compared to physiological norm, as well as a significant decrease in IgG and enhance in IgM production against the levels found in the comparison group. Wehave also shown an enhanced total sensitization in 55.0% of the observation group as shown by the total IgE test compared with normal age ranges, as well as excessive specific sensitization to strontium by 2.49 times, according to the IgG criterion. Disturbance in apoptosis triggering was associated with decreased number of CD95+ lymphocytes and TNFR1+ cells (2.8-fold compared to reference values), shifted balance in apoptogenic proteins, an average of 2.6-fold decrease in Bcl-2 expression, a 2.8-fold reduction of the p53 transcription factor expression relative to the reference interval. Thus, we have shown an ability of strontium excess in drinking water to influence the most important indices of immune regulation in pediatric population. These changes may serve as indices of populational health status under of external strontium exposure.

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Strontium Chloride: Can It Be a New Treatment Option for Ulcerative Colitis?

Cited by 13 publications

References 15 publications

Effects of strontium ranilate and Hypericum perforatum extract on experimental colitis model in rats

Effects of strontium ranilate and Hypericum perforatum extract on experimental colitis model in rats

Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology

Сhanges of Immunoregulatory Indexes in Children Exposed to Strontium

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