Strontium doped hydroxyapatite biomimetic coatings on Ti6Al4V plates

Avci, Muhammed Onur; Yılmaz, Bengi; Tezcaner, Ayşen; Evis, Zafer

doi:10.1016/j.ceramint.2017.04.117

Cited by 51 publications

(19 citation statements)

References 35 publications

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“…It also proves that Sr ions were successfully added to the coated surface with GIL. Some studies report that precise control over the concentration of Ca and Sr in the coating is a key factor to enhance the cell cytocompatibility, osseointegration, and the bone healing effect of endosseous implants, because an excessively high concentration of Sr in the coating would be harmful to cell growth and would induce defective bone mineralization 40,41 . Therefore, EDS analysis results affected by voltage parameter can well support us to obtain the ideal Ca/P or (Ca + Sr)/P ratios of GIL coatings.…”

Section: Resultsmentioning

confidence: 99%

Direct ceramic coating of calcium phosphate doped with strontium via reactive growing integration layer method on α-Ti alloy

Huang

Yoshimura

2020

Sci Rep

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A strontium (Sr)-doped hydroxyapatite-like coating was deposited on α-Ti alloy via the growing integration layer (GIL) method at various applied voltages. We added 0.03 M strontium hydroxide (Sr(oH) 2 •8H 2 o) to a solution containing calcium acetate and sodium dihydrogen phosphate to produce Sr-doped hydroxyapatite (Sr-HA) coatings. The scanning electron microscope (SEM) images of these coatings showed that all various features, such as average pore size, coating thickness, microhardness, and roughness, were similar to those of HA. As the voltage increased from 250 to 300 V, the amount of micro cracks decreased, and there were eliminated at 350 V. The SEM images also showed that the Sr-HA coatings were closely integrated with the alloy: without any gaps between the oxide layers and the alloy. In addition, energy-dispersive X-ray spectroscopy verified the Sr integration from the bottom up. X-ray diffraction patterns confirmed Sr-HA formation instead of calcium phosphate, even at the lowest voltage of 250 V. The value of E corr increased by 6.6% after raising the voltage from 250 to 350 V. The electrochemical impedance spectroscopy analysis confirmed that the adequate corrosion resistance of Sr-HA coatings, especially at the highest voltage of 350 V. In addition, the GIL treatment increased the layer resistance measured by R p /R c. optimally, the GiL method used the highest voltage of 350 V to produce higher quality of Sr-HA-rich coatings. Due to their favorable mechanical properties, titanium (Ti) alloys are considered excellent implant alloys 1,2. Many kinds of Ti alloys were designed for applications in dental treatment and clinical surgery. Ti-Cu alloys have valuable mechanical properties like hardness and yield strength, and chemical properties, such as corrosion resistance and antibacterial effect. It is common belief that Ti-Cu alloy can improve by increasing the Cu contents 3. The higher Cu content and fine Ti 2 Cu phase compounds increase the performance resulting in a stronger antibacterial ability and higher strength. In addition, the Cu ions do not lead to cell cytotoxicity. The alloys particularly exhibit very good cell biocompatibility and do not influence cell proliferation or differentiation even if the Cu ion content is increased to 25 wt% 4-6. However, such alloys still need to be coated with a layer of biocompatible protective bioactive ceramics. Calcium phosphates are essential for such creamics. They improve corrosion protection of mechanical property. In addition, they enhance bone regeneration at the beginning apposition stage, and also regeneration of hard tissues in tissue engineering 7-10. Among various calcium phosphates, HA is a major component of human bones and teeth 11,12. During the past two decades, various surface treatments and deposition techniques for the HA coating of the Ti alloys have been studied. These techniques include plasma sprayed deposition, thermal spraying, ion beam assisted deposition (IBAD), sputtering, micro-arc oxidation (MAO), hot isostatic pressing, dip coat...

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Section: Resultsmentioning

confidence: 99%

Direct ceramic coating of calcium phosphate doped with strontium via reactive growing integration layer method on α-Ti alloy

Huang

Yoshimura

2020

Sci Rep

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“…Yamashita et al reported the chemical effects of the electrically polarized HAp in simulated body fluid [23] and in addition enhanced the in vitro bioactivity and in vivo osteoconductivity [24,25]. Similarly, the bioactivity of HAp has been improved by doping of metal ions viz., iron [26,27], silver [28,29], magnesium [30,31], strontium [32,33], etc., in HAp. Co-dopants like magnesium-silver ions [34], ironzinc [35], etc., have also been used for augmenting physical and biological properties.…”

Section: Introductionmentioning

confidence: 99%

Impact of Dopants on the Electrical and Optical Properties of Hydroxyapatite

Arul¹,

Ramya²,

Kalkura³

2020

Biomaterials

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This chapter deals with the effect of alternating electrical current on hydroxyapatite [HAp, Ca10(PO4)6(OH)2] and doped HAp along with their optical response and the processes involved. The dielectric constant, permittivity and ac conductivity were analyzed to have an insight into the surface charge polarization phenomenon. Further, the magnitude and the polarity of the surface charges, microstructure, and phases also play significant role in the cell proliferation and growth on the implants. Besides, the mechanism behind the electrical properties and the healing of bone fracture are discussed. The influence of various dopants on the optical properties of HAp viz., absorbance, transmission, band gaps and defects energy levels are analyzed along with the photoluminescence and excitation independent emission. In the future outlook, the analysis of effect of doping is summarized and its impact on the next generation biomaterials are elucidated.

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“…22 Additionally, Sr can replace the lattice sites of Ca in HA to form a continuous solid-solution (Sr,x-HA, x is fraction of substitution) up to full substitution (Sr-apatite) with improved mechanical properties and biological performance. 17,[23][24][25] There have been intensive studies to incorporate Sr into HA cements 16,[26][27][28] or coatings 24,[29][30][31][32] for better bone response. Furthermore, the degradation and resulted osteoblast response of Sr,x-HA exhibit a dose dependent behaviour.…”

Section: Introductionmentioning

confidence: 99%