Strontium fructose 1,6-diphosphate alleviates early diabetic testopathy by suppressing abnormal testicular matrix metalloproteinase system in streptozocin-treated rats

Abstract

FDP-Sr or testosterone propionate significantly normalized expression and activity of the MMPs-TIMPs system to attenuate changes in serum testosterone, marker enzymes and histology in testis. Effects of FDP-Sr were dose-dependent and comparable with those of testosterone propionate. By supplying extra energy, FDP-Sr could be promising in treating diabetic testopathy by normalizing abnormal MMP-9 and its endogenous inhibitors in testes.

A new insight into the dissociating effect of strontium on bone resorption and formation

“…These data are supported by a recent study using strontium fructose 1,6-diphosphate in rats [47]. Our results could also partially explain the anti-resorptive effect of strontium, by modifying the MMP-1 and MMP-2 synthesis capacity of cells of the osteoblastic lineage which are implicated in the activation of bone degradation.…”

The Effects of N-Acetylcysteine on MMP-2 and MMP-9 Immune Activities in Testicular Tissue of Streptezotocin Induced Diabetic Rats

“…4 A significant reduce was described the activity of latent MMP-2, active MMP-2 and MMP-9 in diabetic testes by using diff erent techniques and decreases in MMP-2 and MMP-9 have been associated with testopathy. 54 When the literature on the subject is viewed collectively, the detrimental eff ects of both increases and decreases of MMPs levels are damaging for the total health of the organism.…”

Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein

“…Inflammatory reactions have been recognized as common phenomena involved in cardiac ischaemia and failure, atherosclerosis, diabetes and its cardiovascular complications. The biomarkers of pro‐inflammatory cytokines, ET‐1, NADPH oxidase, leptin, ROS, matrix metalloproteinases (MMPs) and Cx43, play roles in these lesions in diabetic complications (cardiomyopathy, nephropathy and orchidopathy), as well as in rheumatic arthritis and osteoarthritis [27–30] . Therefore, the anti‐inflammatory activity of rhein and argirein is potentially equal in alleviating diabetic insults in these aforementioned disorders, and in fact, diabetic nephropathy in streptozotocin‐injected rats was attenuated by argirein significantly [22] …”

“…The biomarkers of pro-inflammatory cytokines, ET-1, NADPH oxidase, leptin, ROS, matrix metalloproteinases (MMPs) and Cx43, play roles in these lesions in diabetic complications (cardiomyopathy,nephropathy and orchidopathy), as well as in rheumatic arthritis and osteoarthritis. [27][28][29][30] Therefore, the anti-inflammatory activity of rhein and argirein is potentially equal in alleviating diabetic insults in these aforementioned disorders, and in fact, diabetic nephropathy in streptozotocin-injected rats was attenuated by argirein significantly. [22] As the main source of ROS, the catalytic (gp91phox) and regulatory (p22phox) subunits of NADPH oxidase were upregulated in carrageenan-induced acute inflammation, in agreement with an involvement of activated NADPH oxidase in adjuvant arthritis-related inflammatory lesions.…”