Structural aberrations of the brain associated with migraine: A narrative review

Kim, Sang-Yong; Nikolova, Simona; Schwedt, Todd J.

doi:10.1111/head.14189

Cited by 9 publications

(7 citation statements)

References 92 publications

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“…For example, the gray matter volume is decreased in the raphe magnus nucleus (NRM) and medullary dorsal horn, while the mean diffusivity is increased in those areas in TMD pain [ 52 ]. Similar findings are observed in headache and visceral pain patients [ 72 , 73 ].…”

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humansupporting

confidence: 87%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humansupporting

confidence: 87%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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“…On the other hand, 16 GM regions had significantly decreased mean CCs with WM in patients with MWoA (16 GM regions after FDR correction, 15 GM regions after P < 1/N correction), including some areas that are part of the somatosensory regions, auditory cortex, frontal areas, temporal gyrus, cingulate cortex, and parietal cortex. In line with previous studies ( Zhang et al, 2016 , 2017a , b ; Jia and Yu, 2017 ; Ashina et al, 2021 ; Kim et al, 2021 ), migraine as a complex brain disease involves functional abnormalities in multiple cortical regions. These GM regions are believed to play critical roles in the pathophysiology of migraines.…”

Section: Discussionsupporting

confidence: 89%

Disrupted White Matter Functional Connectivity With the Cerebral Cortex in Migraine Patients

Qin

Liang

et al. 2022

Front. Neurosci.

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Background: In attempts to understand the migraine patients’ overall brain functional architecture, blood oxygenation level-dependent (BOLD) signals in the white matter (WM) and gray matter (GM) were considered in the current study. Migraine, a severe and multiphasic brain condition, is characterized by recurrent attacks of headaches. BOLD fluctuations in a resting state exhibit similar temporal and spectral profiles in both WM and GM. It is feasible to explore the functional interactions between WM tracts and GM regions in migraine.Methods: Forty-eight migraineurs without aura (MWoA) and 48 healthy controls underwent resting-state functional magnetic resonance imaging. Pearson’s correlations between the mean time courses of 48 white matter (WM) bundles and 82 gray matter (GM) regions were computed for each subject. Two-sample t-tests were performed on the Pearson’s correlation coefficients (CC) to compare the differences between the MWoA and healthy controls in the GM-averaged CC of each bundle and the WM-averaged CC of each GM region.Results: The MWoAs exhibited an overall decreased average temporal CC between BOLD signals in 82 GM regions and 48 WM bundles compared with healthy controls, while little was increased. In particular, WM bundles such as left anterior corona radiata, left external capsule and bilateral superior longitudinal fasciculus had significantly decreased mean CCs with GM in MWoA. On the other hand, 16 GM regions had significantly decreased mean CCs with WM in MWoA, including some areas that are parts of the somatosensory regions, auditory cortex, temporal areas, frontal areas, cingulate cortex, and parietal cortex.Conclusion: Decreased functional connections between WM bundles and GM regions might contribute to disrupted functional connectivity between the parts of the pain processing pathway in MWoAs, which indicated that functional and connectivity abnormalities in cortical regions may not be limited to GM regions but are instead associated with functional abnormalities in WM tracts.

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“…These T1-weighted magnetic resonance imaging (MRI) studies used voxel-based morphometry or surface-based morphometry to explore brain morphology differences in 10. 3389/fnins.2023.1148458 volume, thickness or surface area (SA) between migraine patients and healthy controls (DaSilva et al, 2007;Schmidt-Wilcke et al, 2008;Datta et al, 2011;Messina et al, 2013;Rocca et al, 2014;Coppola et al, 2017;Husøy et al, 2019;Amin et al, 2021;Kim et al, 2021). Currently, migraine has been hypothesized to be a both neuronal and vascular genetic disorder upon the mainstream opinion (Schwedt and Dodick, 2009;MacGregor, 2017).…”

Section: Introductionmentioning

confidence: 99%

Association between brain structures and migraine: A bidirectional Mendelian randomization study

Guo

Wang²,

Ying³

et al. 2023

Front. Neurosci.

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BackgroundAccumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding.MethodsWe carried on a bidirectional Mendelian randomization analysis in order to identify the causal relationship between brain structures and migraine risk. Summary-level data and independent variants used as instruments came from large genome-wide association studies of total surface area and average thickness of cortex (33,992 participants), gray matter volume (8,428 participants), white matter hyperintensities (50,970 participants), hippocampal volume (33,536 participants), and migraine (102,084 cases and 771,257 controls).ResultsWe identified suggestive associations of the decreased surface area (OR = 0.85; 95% CI, 0.75–0.96; P = 0.007), and decreased hippocampal volume (OR = 0.74; 95% CI, 0.55–1.00; P = 0.047) with higher migraine risk. We did not find any significant association of gray matter volume, cortical thickness, or white matter hyperintensities with migraine. No evidence supporting the significant association was found in the reverse MR analysis.ConclusionWe provided suggestive evidence that surface area and hippocampal volume are causally associated with migraine risk.

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Structural aberrations of the brain associated with migraine: A narrative review

Cited by 9 publications

References 92 publications

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Disrupted White Matter Functional Connectivity With the Cerebral Cortex in Migraine Patients

Association between brain structures and migraine: A bidirectional Mendelian randomization study

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