Structural alignment guides oriented migration and differentiation of endogenous neural stem cells for neurogenesis in brain injury treatment

Chai, Yi; Zhao, He; Gao, Xiaohan; Cao, Zheng; Lü, Jiaju; Sun, Qingling; Liu, Wei; Zhang, Zhe; Yang, Junyi; Wang, Xuelin; Chen, Tuoyu; Kong, Xiangdong; Mikos, Antonios G.; Zhang, Xiaohua; Zhang, Yuqi; Wang, Xiumei

doi:10.1016/j.biomaterials.2021.121310

Cited by 28 publications

(15 citation statements)

References 52 publications

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“…Neural cells can promote nerve repair by paracrine and other manners, biomaterials developed on basis of this mechanism can guide nerve regeneration and provide a suitable growth environment for neural cells. Transplants loaded with functional biomaterials can also promote neurogenesis and other repair processes ( Chai et al, 2021 ), showing good therapeutic effects in a variety of animal models including brain injury and spinal cord injury. In regenerative medicine, the in vitro model of primary neurons as an important tool can provide supplementary validation and theoretical basis for animal experiments.…”

Section: Discussionmentioning

confidence: 99%

Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective

Zhang

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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Central nervous system (CNS) diseases have been a growing threat to the health of humanity, emphasizing the urgent need of exploring the pathogenesis and therapeutic approaches of various CNS diseases. Primary neurons are directly obtained from animals or humans, which have wide applications including disease modeling, mechanism exploration and drug development. However, traditional two-dimensional (2D) monoculture cannot resemble the native microenvironment of CNS. With the increasing understanding of the complexity of the CNS and the remarkable development of novel biomaterials, in vitro models have experienced great innovation from 2D monoculture toward three-dimensional (3D) multicellular culture. The scope of this review includes the progress of various in vitro models of primary neurons in recent years to provide a holistic view of the modalities and applications of primary neuron models and how they have been connected with the revolution of biofabrication techniques. Special attention has been paid to the interaction between primary neurons and biomaterials. First, a brief introduction on the history of CNS modeling and primary neuron culture was conducted. Next, detailed progress in novel in vitro models were discussed ranging from 2D culture, ex vivo model, spheroid, scaffold-based model, 3D bioprinting model, and microfluidic chip. Modalities, applications, advantages, and limitations of the aforementioned models were described separately. Finally, we explored future prospects, providing new insights into how basic science research methodologies have advanced our understanding of the CNS, and highlighted some future directions of primary neuron culture in the next few decades.

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Section: Discussionmentioning

confidence: 99%

Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective

Zhang

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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“…[ 51 ] Exogenous NSCs transplantation is deeply studied in a wide range of CNS diseases, [ 49 ] including ischemic stroke, [ 52 ] neurodegenerative diseases, [ 53 ] and traumatic neurological system injuries. [ 54 ] Whereas the regeneration of NSCs in the CNS usually encounters various clinical barriers and cannot accomplish self‐repairing, and the patients of neurological diseases frequently suffer from permanent neurological deficits. First, lots of extrinsic inhibitory substances prevent the CNS from regenerating, e.g., inflammation.…”

Section: Neurological Disordersmentioning

confidence: 99%

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Niu

Zhao

et al. 2023

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Neurological diseases are the foremost cause of disability and the second leading cause of death worldwide. Owing to the special microenvironment of neural tissues and biological characteristics of neural cells, a considerable number of neurological disorders are currently incurable. In the past few years, the development of nanoplatforms based on metal–organic frameworks (MOFs) has broadened opportunities for offering sensitive diagnosis/monitoring and effective therapy of neurology‐related diseases. In this article, the obstacles for neurotherapeutics, including delayed diagnosis and misdiagnosis, the existence of blood brain barrier (BBB), off‐target treatment, irrepressible inflammatory storm/oxidative stress, and irreversible nerve cell death are summarized. Correspondingly, MOFs‐based diagnostic/monitoring strategies such as neuroimaging and biosensors (electrochemistry, fluorometry, colorimetry, electrochemiluminescence, etc.) and MOFs‐based therapeutic strategies including higher BBB permeability, targeting specific lesion sites, attenuation of neuroinflammation/oxidative stress as well as regeneration of nerve cells, are extensively highlighted for the management of neurological diseases. Finally, the challenges of the present research from perspective of clinical translation are discussed, hoping to facilitate interdisciplinary studies at the intersections between MOFs‐based nanoplatforms and neurotheranostics.

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“…This hydrogel can better promote endogenous neurogenesis through Notch, Wnt, Neurotrophin, Axon guidance, and MAPK signaling pathways. [161] In our recent study, a ROS-responsive hydrogel crosslinked by a thioketal-containing hyperbranched polymer (HBPAK), neural specific CQAASIKVAV peptides (IKVAV) and methacrylated HA, was encapsulated with epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and BMSCs for the repair and regeneration of spinal cord injury. [162] This hydrogel system can effectively scavenge the overproduced ROS in pathological microenvironment to protect the neurons and BMSCs against oxidative stress, promoting the nerve regeneration successfully.…”

Section: Regulation Of Behaviors With Endogenous/exogenous Stem Cellsmentioning

confidence: 99%

Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury

Chen

Zhao

et al. 2023

Macromolecular Bioscience

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Traumatic brain injury (TBI), a major public health problem accompanied with numerous complications, usually leads to serve disability and huge financial burden. The adverse and unfavorable pathological environment triggers a series of secondary injuries, resulting in serious loss of nerve function and huge obstacle of endogenous nerve regeneration. With the advances in adaptive tissue regeneration biomaterials, regulation of detrimental microenvironment to reduce the secondary injury and to promote the neurogenesis becomes possible. The adaptive biomaterials could respond and regulate biochemical, cellular, and physiological events in the secondary injury, including excitotoxicity, oxidative stress, and neuroinflammation, to rebuild circumstances suitable for regeneration. In this review, the development of pathology after TBI is discussed, followed by the introduction of adaptive biomaterials based on various pathological characteristics. The adaptive biomaterials carried with neurotrophic factors and stem cells for TBI treatment are then summarized. Finally, the current drawbacks and future perspective of biomaterials for TBI treatment are suggested.

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Structural alignment guides oriented migration and differentiation of endogenous neural stem cells for neurogenesis in brain injury treatment

Cited by 28 publications

References 52 publications

Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective

Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury

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