Structural analysis of fluorine‐containing bioactive glass nanoparticles synthesized by sol–gel route assisted by ultrasound energy

Abstract

In the last decades, studies about the specific effects of bioactive glass on remineralization of dentin were the focus of attention, due to their excellent regenerative properties in mineralized tissues. The incorporation of Fluorine in bioactive glass nanoparticles may result in the formation of fluorapatite (FAP), which is chemically more stable than hydroxyapatite or carbonated hydroxyapatite, and therefore is of interest for dental applications. The aim of this study was to synthesize and characterize a new system of Fluorine-containing bioactive glass nanoparticles (BGNPF). A sol-gel route assisted by ultrasound was used for the synthesis of BGNPF. The particles obtained were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), atomic force microscopy (AFM), X-ray diffraction (XRD), dynamic light scattering (DLS), nitrogen adsorption, and X-ray photoelectron spectroscopy (XPS). SEM micrographs showed that the particles are quite uniform spherical nanostructures, occurring agglomeration or partial sinterization of the particulate system after heat treatment. XRD and XPS analysis results suggest the formation of fluorapatite crystals embedded within the matrix of the bioactive glass nanoparticles.

Magnesium-Based Bioactive Composites Processed at Room Temperature

“…It was already reported that these defects can display a negative influence on the corrosion resistance of magnesium in physiological media [46]. Thus, in practice, the particle size of BG could be decreased by, for example, either ball-milling or the use of a different sol-gel route [47].…”

Advances and challenges in regenerative dentistry: A systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells

“…Conversely, undiluted cement significantly inhibited the migration and proliferation of hDPSCs [ 60 ]. Furthermore, notable research trends included the predominant use of these materials for addressing dentine hypersensitivity [ 61 , [133] , [134] , [135] , [136] , [137] , [138] , [139] , [140] ] or promoting dentine regeneration [ 65 , 141 ].…”

Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing

“…The sphericity of bioactive glass particles is an important feature for dental applications, such as in the treatment of dentin hypersensitivity, since the irregular morphology could cause micro-cuts and micro-injuries at the implant site, increasing the healing time 2,8,14 . Moreover, the cell adhesion and proliferation in materials with spherical morphology are greater when compared to materials with irregular morphology since there will not be a physical barrier to prevent their movement 22 .…”

“…From the 5th day it is possible to identify a peak related to sodium chloride (JCPDS 5-0628), that may have precipitated from the SBF solution, once this solution has a high concentration of Na + and Clions. After 28 days of immersion, samples BGFM and BGFU presented peaks related to carbonated hydroxyapatite and / or fluorapatite (JCPDS 31-267), however the distinction of the two phases is hampered by the isomorphic property of these two minerals, so their peaks would be overlapping 2,44 . Al-Noaman and co-workers showed that CaF 2 have an influence on bioactivity of the glasses, but are not incompatible with osteoblast-like cell viability because the cells were able to grow and proliferate on the glass surface, thus this implies that CaF 2 enriched glass may be useful for stimulating osteoblastic growth and bone formation in vivo 45 .…”