Structural and functional abnormality of the putamen in children with developmental dyslexia

Wang, Zhao; Yan, Xiao‐Xin; Liu, Yanni; Spray, Gregory J.; Deng, Yuan; Cao, Fan

doi:10.1016/j.neuropsychologia.2018.07.014

Cited by 31 publications

(24 citation statements)

References 88 publications

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“…Corticostriatal and hippocampal learning systems are implicated in language and procedural learning, impairments of which have been associated with reading de cits [11,60] . Consistent with our results, few previous studies have revealed GM anomalies in the left striatum in DD [40,54] . It has been shown that the connectivity between the left striatum and insula are important in reading, especially in children, suggesting its essential role in early reading acquisition [61] .…”

Section: Discussionsupporting

confidence: 93%

Reading-Skill Associated Grey Matter Abnormalities in Dyslexia: Voxel- and Surface-Based Whole-Brain Analysis

Kujala

Sihvonen

Thiede

et al. 2021

Preprint

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Developmental dyslexia (DD) is the most prevalent neurodevelopmental disorder with a substantial negative influence on the individual’s academic achievement and career. Research on its neuroanatomical origins has continued for half a century, yielding, however, inconsistent results, lowered total brain volume being the most consistent finding. We set out to evaluate the grey matter (GM) volume and cortical abnormalities in adult dyslexic individuals, employing a combination of whole-brain voxel- and surface-based morphometry following current recommendations on analysis approaches, coupled with rigorous neuropsychological testing. Whilst controlling for age, sex, total intracranial volume, and performance IQ, we found both decreased GM volume and cortical thickness in the left insula in participants with DD. Moreover, they had decreased GM volume in left superior temporal gyrus, putamen, globus pallidus, and parahippocampal gyrus. Higher GM volumes and cortical thickness in these areas correlated with better reading and phonological skills, deficits of which are pivotal to DD. Crucially, total brain volume did not influence our results, since it did not differ between the groups. Our findings demonstrating abnormalities in brain areas in individuals with DD, which previously were associated with phonological processing, are compatible with the leading hypotheses on the neurocognitive origins of DD.

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Section: Discussionsupporting

confidence: 93%

Reading-Skill Associated Grey Matter Abnormalities in Dyslexia: Voxel- and Surface-Based Whole-Brain Analysis

Kujala

Sihvonen

Thiede

et al. 2021

Preprint

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“…25 Another morphometric study found that children with developmental dyslexia had smaller left putamen volumes compared with typically developing peers, and the smaller left putamen volume was associated with deficits in phonological processing, a component of language development. 26 Furthermore, a recent meta-analysis examining the relationship between the putamen and language using connectivity modeling methodology highlighted relationships between the left putamen and other regions of interest in the left hemisphere (i.e., inferior frontal lobe, superior temporal gyrus, middle frontal gyrus, and inferior parietal lobe) associated with language comprehension and production. 27 The present study also revealed relationships between white matter microstructural changes in the centrum semiovale and neurodevelopment.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study

et al. 2019

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Aim: Hypoxic-ischemic encephalopathy is associated with damage to deep gray matter; however, white matter involvement has become recognized. This study explored differences between patients and clinical controls on diffusion tensor imaging, and relationships between diffusion tensor imaging and neurodevelopmental outcomes. Method: Diffusion tensor imaging was obtained for 31 neonates after hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and 10 clinical controls. A subgroup of patients with hypoxic-ischemic encephalopathy (n = 14) had neurodevelopmental outcomes correlated with diffusion tensor imaging scalars. Results: Group differences in diffusion tensor imaging scalars were observed in the putamen, anterior and posterior centrum semiovale, and the splenium of the corpus callosum. Differences in these regions of interest were correlated with neurodevelopmental outcomes between ages 20 and 32 months. Conclusion: Therapeutic hypothermia may not be a complete intervention for hypoxic-ischemic encephalopathy, as neonatal white matter changes may continue to be evident, but further research is warranted. Patterns of white matter change on neonatal diffusion tensor imaging correlated with neurodevelopmental outcomes in this exploratory pilot study.

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Section: Introductionmentioning

confidence: 99%

“…The putamen, a round brain structure located at the basal ganglia, is a significant dorsal striatum [1]. The putamen is involved in a wide range of motivated behaviors, decision making, and addiction [1]. As part of the brain reward system, putamen is a part of the brain's dopaminergic system that influences a wide range of motivated behaviors including eating [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Resting-State Functional Connectivity between Putamen and Salience Network and Childhood Body Mass Index

Assari

Boyce

2021

Neurology International

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Introduction: Although the putamen has a significant role in reward-seeking and motivated behaviors, including eating and food-seeking, minorities’ diminished returns (MDRs) suggest that individual-level risk and protective factors have weaker effects for Non-Hispanic Black than Non-Hispanic White individuals. However, limited research is available on the relevance of MDRs in terms of the role of putamen functional connectivity on body mass index (BMI). Purpose: Building on the MDRs framework and conceptualizing race and socioeconomic status (SES) indicators as social constructs, we explored racial and SES differences in the associations between putamen functional connectivity to the salience network and children’s BMI. Methods: For this cross-sectional study, we used functional magnetic resonance imaging (fMRI) data of 6473 9–10-year-old Non-Hispanic Black and Non-Hispanic White children from the Adolescent Brain Cognitive Development (ABCD) study. The primary independent variable was putamen functional connectivity to the salience network, measured by fMRI. The primary outcome was the children’s BMI. Age, sex, neighborhood income, and family structure were the covariates. Race, family structure, parental education, and household income were potential moderators. For data analysis, we used mixed-effect models in the overall sample and by race. Results: Higher right putamen functional connectivity to the salience network was associated with higher BMI in Non-Hispanic White children. The same association was missing for Non-Hispanic Black children. While there was no overall association in the pooled sample, a significant interaction was found, suggesting that the association between right putamen functional connectivity to the salience network and children’s BMI was modified by race. Compared to Non-Hispanic White children, Non-Hispanic Black children showed a weaker association between right putamen functional connectivity to the salience network and BMI. While parental education and household income did not moderate our association of interest, marital status altered the associations between putamen functional connectivity to the salience network and children’s BMI. These patterns were observed for right but not left putamen. Other/Mixed Race children also showed a pattern similar to Non-Hispanic Black children. Conclusions: The association between right putamen functional connectivity to the salience network and children’s BMI may depend on race and marital status but not parental education and household income. While right putamen functional connectivity to the salience network is associated with Non-Hispanic White children’s BMI, Non-Hispanic Black children’ BMI remains high regardless of their putamen functional connectivity to the salience network. This finding is in line with MDRs, which attributes diminished effects of individual-risk and protective factors for Non-Hispanic Black children to racism, stratification, and segregation.

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Structural and functional abnormality of the putamen in children with developmental dyslexia

Cited by 31 publications

References 88 publications

Reading-Skill Associated Grey Matter Abnormalities in Dyslexia: Voxel- and Surface-Based Whole-Brain Analysis

Reading-Skill Associated Grey Matter Abnormalities in Dyslexia: Voxel- and Surface-Based Whole-Brain Analysis

Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study

Resting-State Functional Connectivity between Putamen and Salience Network and Childhood Body Mass Index

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