Structural and functional characterization of TrmM in m⁶A modification of bacterial tRNA

Abstract

N 6 -methyladenosine (m 6 A), widely distributed in both coding and noncoding RNAs, regulates the epigenetic signals and RNA metabolism in eukaryotes.Although this posttranscriptional modification is frequently observed in messenger and ribosomal RNA, it is relatively rare in transfer RNA. In Escherichia coli, TrmM encoded by yfiC is the tRNA-specific N 6 methyltransferase, which