Structural and mechanical characterisation of the peri-prosthetic tissue surrounding loosened hip prostheses. An explorative study

Moerman, A. M.; Zadpoor, Amir A.; Oostlander, A.E.; Schoeman, Monique A.E.; Moshtagh, P. Rahnamay; Pouran, Behdad; Valstar, Edward R.

doi:10.1016/j.jmbbm.2016.04.009

Cited by 9 publications

(10 citation statements)

References 29 publications

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“…The clinical success of endosseous implant surgery is strongly dependent on osseointegration phenomena (Khan et al, 2012). The biological tissues surrounding an implant are initially non-mineralized and may thus be described as a soft tissue (Moerman et al, 2016). During normal osseointegration processes, periprosthetic bone tissue is progressively transformed into mineralized bone, which may be described as a solid.…”

Section: Introductionmentioning

confidence: 99%

Reflection of an ultrasonic wave on the bone-implant interface: A numerical study of the effect of the multiscale roughness

Hériveaux

Nguyen

Haïat

2018

The Journal of the Acoustical Society of America

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Quantitative ultrasound is used to characterize and stimulate osseointegration processes at the bone-implant interface (BII). However, the interaction between an ultrasonic wave and the implant remains poorly understood. This study aims at investigating the sensitivity of the ultrasonic response to the microscopic and macroscopic properties of the BII and to osseointegration processes. The reflection coefficient R of the BII was modeled for different frequencies using a two-dimensional finite element model. The implant surface roughness was modeled by a sinusoidal function with varying amplitude h and spatial frequency L. A soft tissue layer of thickness W was considered between bone tissue and the implant in order to model non-mineralized fibrous tissue. For microscopic roughness, R is shown to increase from around 0.55 until 0.9 when kW increases from 0 to 1 and to be constant for kW > 1, where k is the wavenumber in the implant. These results allow us to show that R depends on the properties of bone tissue located at a distance comprised between 1 and 25 μm from the implant surface. For macroscopic roughness, R is highly dependent on h and this dependence may be explained by phase cancellation and multiple scattering effects for high roughness parameters.

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Section: Introductionmentioning

confidence: 99%

Reflection of an ultrasonic wave on the bone-implant interface: A numerical study of the effect of the multiscale roughness

Hériveaux

Nguyen

Haïat

2018

The Journal of the Acoustical Society of America

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“…However, ( Kraaij et al 2014;Moerman et al 2016). Further studies should evaluate the repercussions of the hyperelastic modeling of interfacial tissue on micromotion-induced fluid flow predictions.…”

Section: Discussionmentioning

confidence: 99%

Micromotion-induced peri-prosthetic fluid flow around a cementless femoral stem

Camine

Terrier

Pioletti

2017

Computer Methods in Biomechanics and Biomedical Engineering

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Micromotion-induced interstitial fluid flow at the bone-implant interface has been proposed to play an important role in aseptic loosening of cementless implants. High fluid velocities are thought to promote aseptic loosening through activation of osteoclasts, shear stress induced control of mesenchymal stem cells differentiation, or transport of molecules. In this study, our objectives were to characterize and quantify micromotion-induced fluid flow around a cementless femoral stem using finite element modeling. With a 2D model of the bone-implant interface and full-factorial design, we first evaluated the relative influence of material properties, and bone-implant micromotion and gap on fluid velocity. Transverse sections around a femoral stem were built from computed tomography images, while boundary conditions were obtained from experimental measurements on the same femur. In a second step, a 3D model was built from the same data-set to estimate the shear stress experienced by cells hosted in the peri-implant tissues. The full-factorial design analysis showed that local micromotion had the most influence on peak fluid velocity at the interface. Remarkable variations in fluid velocity were observed in the macrostructures at the surface of the implant in the 2D transverse sections of the stem. The 3D model predicted peak fluid velocities extending up to 2.2 mm/s in the granulation tissue and to 3.9 mm/s in the trabecular bone. Peak shear stresses on the cells hosted in these tissues ranged from 0.1 to 12.5 Pa. These results offer insight into mechanical stimuli encountered at the bone-implant interface.

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“…However, an excessive level (typically above 150 µm) results in the formation of peri-prosthetic fibrous tissue instead of an osseointegrated interface [61][62][63]. Note that fibrous tissue has a stiffness of around 0.5-2.0 kPa [64], which is several orders of magnitude less rigid than both mature and newly formed bone tissue at the BII. The presence of fibrous tissue therefore affects the load-bearing capacity of the implant and leads to a vicious circle (since micromotions are further enhanced) responsible for implant failures.…”

Section: Osseointegration and Secondary Stabilitymentioning

confidence: 99%

“…A complementary study has shown that Young's modulus of newly formed bone tissue also depends on the implant surface treatment since the apparent indentation modulus (respectively the hardness) of periprosthetic bone was around 1.5 (respectively 3) times higher around acid-etched titanium than around machined titanium [6]. Atomic force microscopy (AFM) is another method used to study the mechanical properties of newly formed bone tissue near the BII and allows work at a lower scale than nanoindentation [64]. The principle of the measurements relies on the analysis of the deflection of a cantilever with a predetermined stiffness.…”

Section: Nanoindentation and Atomic Force Microscopymentioning

confidence: 99%

Biomechanical behaviours of the bone–implant interface: a review

Gao

Fraulob

Haïat

2019

J. R. Soc. Interface.

168

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In recent decades, cementless implants have been widely used in clinical practice to replace missing organs, to replace damaged or missing bone tissue or to restore joint functionality. However, there remain risks of failure which may have dramatic consequences. The success of an implant depends on its stability, which is determined by the biomechanical properties of the bone–implant interface (BII). The aim of this review article is to provide more insight on the current state of the art concerning the evolution of the biomechanical properties of the BII as a function of the implant's environment. The main characteristics of the BII and the determinants of implant stability are first introduced. Then, the different mechanical methods that have been employed to derive the macroscopic properties of the BII will be described. The experimental multi-modality approaches used to determine the microscopic biomechanical properties of periprosthetic newly formed bone tissue are also reviewed. Eventually, the influence of the implant's properties, in terms of both surface properties and biomaterials, is investigated. A better understanding of the phenomena occurring at the BII will lead to (i) medical devices that help surgeons to determine an implant's stability and (ii) an improvement in the quality of implants.

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Structural and mechanical characterisation of the peri-prosthetic tissue surrounding loosened hip prostheses. An explorative study

Cited by 9 publications

References 29 publications

Reflection of an ultrasonic wave on the bone-implant interface: A numerical study of the effect of the multiscale roughness

Reflection of an ultrasonic wave on the bone-implant interface: A numerical study of the effect of the multiscale roughness

Micromotion-induced peri-prosthetic fluid flow around a cementless femoral stem

Biomechanical behaviours of the bone–implant interface: a review

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