Structural and process controls of AIEgens for NIR-II theranostics

Abstract

Structural and process controls of NIR-II AIEgens realize manipulating of radiative (R) and nonradiative (NR) decay for precise theranostics.

Aggregation-Induced Generation of Reactive Oxygen Species: Mechanism and Photosensitizer Construction

“…In recent years, many AIE–PS nanoparticles (NPs) have been designed based on the same strategy [ 52 , 53 ]. Moreover, by connecting thiophene ring or benzothiophene ring between the donor and the acceptor structure, AIE–PS with red-shifted emission and better performance can be obtained [ 66 , 67 ]. Wang reported a metal–organic framework (ZIF-8, ZIF = zeolitic imidazolate framework) by AIE–PS 8 assisted in vivo self-assembly nanoplatform, ZIF-8-PMMA-S-S-mPEG (nanoparticle 8 ), as an effective tool for organic PS payload to achieve efficient PDT [ 53 ].…”

Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens

“…To establish the xenogra 4T1 tumour-bearing mouse model, 4T1 breast cancer cells (1 Â 10 6 ) suspended in 30 mL of RPMI-1640 medium were injected subcutaneously into the right axillary space of the BALB/c mouse. Aer 9 days, the mice with tumour volumes of about 80-120 mm 3 were used subsequently.…”

“…Near-infrared (NIR, >650 nm) uorescence imaging has attracted considerable attention from both fundamental researchers and the clinical community, as it has lower autouorescence interference, causes less photodamage, and has better penetration capability as compared with visible light, making it a preferable option for biological imaging. [1][2][3] A lot of NIR uorophores have been developed, for example, quantum dots, carbon nanomaterials, rare earth-doped nanoparticles (NPs), and organic emitters. [4][5][6][7] Among them, organic materials hold great promise for clinical translation due to the salient merits of good biocompatibility, a well-dened chemical structure, facile modication, large-scale production, and potential degradation.…”

Hypoxia-activated probe for NIR fluorescence and photoacoustic dual-mode tumor imaging

“…AIEgens commonly show enhanced emission in the aggregated state, which is mainly attributed to the restriction of intramolecular motions. AIEgens have made great contributions to bioimaging applications, especially those in the ll OPEN ACCESS near-infrared (NIR) window, by regulating multi-hierarchical structures from single-molecule to molecular aggregates (Liu et al, 2020;Xu et al, 2020b;Zhang et al, 2020;Zhao et al, 2020). AIE effect endows molecules with high fluorescence efficiency while the TICT effect enables a red-shifted emission and enhanced non-radiative relaxation (Li et al, 2015(Li et al, , 2017.…”