Structural Assessment of Chemical Constituent of Sidaguri (Sida rhombifolia Linn) and Its Ability to Inhibit Cyclooxygenase

Tanumihardja, Maria; Mattulada, Indrya Kirana; Natsir, Nurhayaty; Subehan, Subehan; Mandey, Fredryk; Muslimin, Lukman

doi:10.4034/pboci.2019.191.96

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…14 In dental practice, clove oil, gambir, jatropha, sidaguri and bee venom have been usually used to relieve dental pain by applying them directly to the affected tooth. [4][5][6][7] A preliminary in vitro study in an animal model with periapical lesion showed that the root of sidaguri was able to decrease C-reactive protein level (CRP), one of many molecules that take part in the acute inflammatory process. 8 Another study showed that root of sidaguri was a non-selective COX inhibitor, an enzyme involved in the synthesis of prostaglandin E2.…”

Section: Discussionmentioning

confidence: 99%

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Tanumiharja¹,

Natsir²,

Mattulada³

et al. 2021

J Dentomaxillofac Sci

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Objective:The purpose of this study was to evaluate the effect of herbal alternatives, extract of sidaguri (sida rhombifolia) combine with extract of jatropha sap (jatropha curcas) application on microhardness and morphology of tooth surface. Material and Methods: Twelve upper first premolar teeth were used in this study, prepared to Class I box cavities, and were then allocated into 4 groups (n=3). Group 1-3 were treated groups, applied with combined extracts of a small dose (5 mg), medium dose (25 mg), and high dose (50 mg), while group 4 was the control group. The cavities were restored with composite resin, immersed in artificial saliva, and stored at room temperature for 14 days. The fillings and extracts were removed and cleaned under running tap water. The teeth were cut in a vertical direction towards the apex, sectioned into 1 mm thickness, and evaluated using Laser Scanning Microscope (LSM), then were examined for microhardness test. Results: All treated groups showed significantly lower microhardness than the control group. Tooth porosity was observed, and its extensiveness was affected by doses of extracts. Conclusion:The application of herbal alternatives (extract of sidaguri and jatropha) lowered the microhardness of tooth structure and caused tooth porosities.

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Section: Discussionmentioning

confidence: 99%

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Tanumiharja¹,

Natsir²,

Mattulada³

et al. 2021

J Dentomaxillofac Sci

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“…The active compound Sidaguri has an anti-inflammatory effect by non-selectively inhibiting COX. (16).…”

Section: Discussionmentioning

confidence: 99%

“…In the Usada Wariga Dalem text it is also mentioned that the sidaruri plant can be used as a fever reducer. If you look at the results of research on these plants, sidaguri contains active compounds that have an anti-inflammatory effect by non-selectively inhibiting COX (16).…”

Section: Methodsmentioning

confidence: 99%

Traditional Antipyretics from the text of Usada Wariga Dalem as an Ayurveda knowledge

Sariani¹,

Rasna²,

Martha³

et al. 2021

IJAM

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Text Usada Wariga Dalem is one of Usada in Bali as a national cultural heritage which contains the knowledge system of traditional Balinese treatment which includes symptoms of disease, names of diseases, medicinal facilities, how to mix, and how to treat. One of the symptoms contained in the text of Usada Wariga Dalem usada is fever. Handling of fever can be done by using medicinal plants as contained in the text of Usada Wariga Dalem. Treatment with medicinal herbs is still one of the options for Balinese people in treating diseases. Traditional medicinal herbs for fever are often used as alternative and complementary medicines. This research examined what included fever in the text of Usada Wariga Dalem, what were the ingredients of fever medicine in the text of Usada Wariga Dalem and how the medicine could be a complementary and alternative medicine for the Balinese people. This research used a descriptive qualitative research method. literature study and ethnography method. The data needed in this study were collected using a library study, observation, and in-depth interviews. The data is sourced from the Usada Wariga Dalem lontar text, which was collected at the Lontar Study Center, Faculty of Cultural Sciences, Udayana University. The traditional medicine for fever contained in the Usada Wariga Dalem text can be used for complementary and alternative medicine. This traditional treatment using medicinal ingredients from processed plants, has been proven to reduce the patient's fever.

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“…Similarly, the phytoconstituents reported in fractions were summarized in Table 5 as per earlier reports. [22][23][24][25] Journal of Young Pharmacists, Vol 13 Issue 4, Oct-Dec, 2021…”

Section: In Vitro Ache Inhibitionmentioning

confidence: 99%

In silico and in vitro Approach To Identify Memory Enhancers from Sida rhombifolia L.

Pattanashetti¹,

Patil²,

Hegde³

2021

JYP

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Background: Sida rhombifolia L. is a well documented Ayurvedic medicine for the management of neurodegenerative diseases and to enhance cognitive function. Researchers demonstrated its activities under various animal model/s, but lack the probable molecular mechanism in the treatment of Alzheimer's disease. Current study was aimed to identify the acetylcholinesterase (AChE) inhibitory potency of phytocompounds and enriched fractions from S.rhombifolia using in vitro and network pharmacology approaches. Methods: Phytocompounds were retrieved from phytochemical databases, scientific reports and quired for druggability. Protein targets were predicted using BindingDB (p≥0.7). STRING database and KEGG pathway were utilized to perform gene set enrichment analysis and to identify the probable pathways modulated by the phytocompounds. Cytoscape v3.6.1 was used to construct a target-compound-pathway network. Docking was performed by PyRx 0.8v. Enriched fractions of S. rhombifolia were tested for in vitro AChE inhibitory potency using the AChE enzyme. Results: Among 35 compounds, 26 compounds showed positive drug likeness property. Out of 26 compounds, 9 compounds i.e. 2D-hydroxyecdysone, ecdysone, pterosterone-3-O-β-D-glucopyranoside, acacetin, kaempferol, sanguinine, vascicine, vasicinol, vasicinone were predicted to target AChE and other 9 therapeutic targets involved in Alzheimer's disease (AD). Acacetin scored lowest binding energy with AChE (-8.9kcal/mol). Among the selected enriched fractions, hexane fraction pertains highest AChE inhibition (IC 50 12.87µg/ml) compared to clinical approved drug Donepezil (IC 50 2.92µg/ml). Conclusion: The role of S.rhombifolia for the management of AD could be attributed due to the major effect of 2D-hydroxyecdysone, ecdysone, pterosterone-3-O-β-Dglucopyranoside, acacetin, kaempferol, sanguinine, vascicine, vasicinol, vasicinone on AChEand their action on multiple protein molecules associated with AD pathogenesis.

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Structural Assessment of Chemical Constituent of Sidaguri (Sida rhombifolia Linn) and Its Ability to Inhibit Cyclooxygenase

Cited by 7 publications

References 8 publications

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Traditional Antipyretics from the text of Usada Wariga Dalem as an Ayurveda knowledge

In silico and in vitro Approach To Identify Memory Enhancers from Sida rhombifolia L.

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